澳门官网_(ӭ)

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          BIOGRAPHICAL SKETCH

           

           

           

          Sachiko Inoue Blaber

           

          Education

           

          INSTITUTION AND LOCATION

          DEGREE

          MM/YY

          FIELD OF STUDY

          University of California Riverside

          B.S.

          06/1984

          Biology

          University of California Irvine

          M.S.

          06/1988

          Biological Chemistry

           

          Positions and Employment

          1989-1990 Research Assistant, Dept. Biology, University of California Riverside

          1995-2016 ?Research Associate, Biomedical Sciences, Florida State University

           

          Other Experience

          1990-93 Graduate Research Assistant, Biological Chemistry, University of California Irvine

           

          Honors & Awards

          2013?Innovator Award, Florida State University

          2013?U.S. Patent 61/759,096, Improved Mouse Jacket, Blaber, M. and Blaber, S. (pending)?

          2010?U.S. Patent 7,754,216 B2, Method of Treating Multiple Sclerosis with Anti-K6 Antibody, Scarisbrick, I.A., Blaber, S.I., Blaber, M. and Rodriguez, M.

          2010?U.S. Patent 12/833,773, Methods and Materials for Treating Inflammatory Conditions, Scarisbrick, I.A., Blaber, S.I., Blaber, M. and Rodriguez, M.

          2008?European Patent 1,513,553 B1, Methods and Materials for Treating and Diagnosing Kallikrein-6 Related Inflammatory Conditions, Scarisbrick, I.A., Blaber, S.I. and Blaber, M.

           

          Peer-reviewed publications (47 total)

           

          47. An S116R Phosphorylation Site Mutation in Human FGF-1 Differentially Affects Mitogenic and Glucose Lowering Activities, Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Ornitz, D., Suh, J.M., Atkins, A.R., Downes, M., Evans, R.M., Bienkiewicz, E., Blaber, M. (submitted)

           

          46 Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "2nd Generation" Therapeutic Application, Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Sutherland, M.A., Tenorio, C. and Blaber, M., J. Pharm. Sci. 105, 1444-1453 (2016) PMID: 27019961

           

          45. Accelerated healing in NONcNZO10/LtJ type 2 diabetic mice by FGF 1, Blaber, S.I., Diaz, J. and Blaber, M. Wound Repair and Regeneration 23, 538-549 (2015) PMID: 25891187

           

          43. Kallikrein-related Peptidase 6: A Biomarker for Traumatic Brain Injury in Rat, Phipps, H., Longo, L., Blaber, S.I., Blaber, M. and VanLandingham, Brain Injury 27, 1698-1706 (2013) PMID: 24266798

          42. Kallikrein cascades in traumatic spinal cord injury: differential roles in axonopathy and neurodegeneration, Radulovic, M., Yoon, H., Wu, J., Larson, N., Linbo, R., Burda, J.E., Diamandis, E.P., Blaber, S.I., Blaber, M., Fehlings, M.G. and Scarisbrick, I.A., Journal of Neuropathology & Experimental Neurology 72, 1072-1089 (2013) PMID: 24128681

           

          41. Kallikrein 6 Signals through PAR1 and PAR2 to Promote Neuron Injury and Exacerbate Glutamate Neurotoxicity, Yoon, H., Radulovic, M., Wu, J., Blaber, S.I., Blaber, M., Fehlings, M.G. and Scarisbrick, I.A., J. Neurochem. 127, 283-298 (2013) PMID: 23647384

           

          40. Clinical Significance and Novel Mechanism of Action of Kallikrein 6 in Glioblastoma, Drucker, K.L., Paulsen, A.R., Giannini, C., Decker, P.A., Blaber, S.I., Blaber, M., Uhm, J.H., O'Neill, B.P., Jenkins, R.B. and Scarisbrick, I.A., Neuro-Oncology 15, 305-318] (2013) PMID: 23307575

           

          39. Activation Profiles of Human Kallikrein-related Peptidases by Matrix Metalloproteinases, Yoon, H., Blaber, S.I., Li, W., Scarisbrick, I.A. and Blaber, M., Biological Chemistry 394, 137-147 (2013) PMID: 23241590

           

          38. Pharmacokinetic properties of 2nd-generation fibroblast growth factor-1 mutants for therapeutic application, Xia, X., Babcock, J.P., Blaber, S.I., Harper, K.M. and Blaber, M., PLoS ONE 7(11): e48210 (2012) PMID: 23133616

           

          37. Isomannide derivatives as new class of inhibitors for human kallikrein 7, Freitas, R.F., Teixeira, T.S., Abrahao, O.Jr., Barros, T.G., Santos, J.A., Kondo, M.Y., Juliano, M.A., Blaber, S.I., Blaber, M., Juliano, L., Antunes, O.A., Muri, E.M., and Puzer, L., Bioorg. Med. Chem. Lett. 22, 6072-5 (2012) PMID: 22959247

           

          36. Kallikrein 6 is a Novel Molecular Trigger of Reactive Astrogliosis, Scarisbrick, I., Radulovic, M., Burda, J., Larson, N., Blaber, S., Gianinni, C., Blaber, M. and Vandell, A., Biol. Chem. 393, 355-67 (2012) PMID: 22505518

           

          35. Kallikrein 6 Regulates Early CNS Demyelination in a Viral Model of Multiple Sclerosis, Scarisbrick, I.A., Yoon, H., Panos, M., Larson, N., Blaber, S.I., Blaber, M. and Rodriguez, M., Brain Pathol. 22, 709-722 (2012) PMID: 22335454

          34. Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7, Teixeira, T.S., Freitas, R,F., Abraho, O. Jr, Devienne, K.F., de Souza, L.R., Blaber, S.I., Blaber, M., Kondo, M.Y., Juliano, M.A., Juliano, L. and Puzer, L., Bioorg. Med. Chem. Lett. 21, 6112-6115 (2011) PMID: 21903387

           

          33. Expression and Function of the Kallikrein-Related Peptidase 6 in the Human Melanoma Microenvironment, Krenzer, S., Peterziel, H., Mauch, C., Blaber, S.I., Blaber, M., Angel, P. and Hess, J., J. Invest. Dermatol.131, 2281-2288 (2011) PMID: 21753781

           

          32. Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates, Andrade, D., Assis, D.M., Santos, J.A.N., Alves, F.M., Hirata, I.Y., Araujo, M.S., Blaber, S.I., Blaber, M., Juliano, M.A. and Juliano, L., Biochimie 93, 1701-1709 (2011) PMID: 21689719

           

          31. Functional role of Kallikrein 6 in Regulating Immune Cell Survival, Scarisbrick, I.A., Epstein, B., Cloud, B., Yoon, H., Wu, J., Blaber, S.I., Blaber, M., Vandell, A.G. and Bryson, A. PLoS ONE 6(3): e18376. doi:10.1371/journal.pone.0018376 (2011) PMID: 21464892

           

          30. A polypeptide "building block" for the ?trefoil fold identified by "top-down symmetric deconstruction", Lee, J., Blaber, S., Dubey, V. and Blaber, M., J. Mol. Biol. 407, 744?63 (2011) PMID: 21315087 (selected by Faculty of 1000; Cover Article)

          29. Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans., Andrade, D., Assis, D.M., Lima, A.R., Oliveira, J.R., Araujo, M.S., Blaber, S.I., Blaber, M., Juliano, M.A. and Juliano, L., Arch. Biochem. Biophys. 498, 74-82 (2010) PMID: 20371359

          28. Functional intersection of the Kallikrein-related peptidases (KLKs) and thrombostasis axis, Blaber, M., Yoon, H., Juliano, M.A., Scarisbrick, I.A., and Blaber, S.I., Biological Chemistry 391, 311-320 (2010) PMID: 20128685

           

          27. Engineering an Improved Crystal Contact across a Solvent-Mediated Interface of Human Fibroblast Growth Factor-1, Meher, A.K., Blaber, S.I., Lee, J., Honjo, E., Kuroki, R. and Blaber, M., Acta Cryst. F. 65, 1136-1140 (2009) PMID: 19923735

          26. X-ray Structure and Biophysical Properties of Rabbit Fibroblast Growth Factor-1, Lee, J., Blaber, S.I., Irsigler, A., Aspinwall, E. and Blaber, M., Acta Cryst. F. 65, 1097-1104 (2009) PMID: 19923726

           

          25. A Completed KLK Activome Profile: Investigation of Activation Profiles of KLK9, 10 and 15, Yoon, H., Blaber, S.I., Debela, M., Goettig, P., Scarisbrick, I.A. and Blaber, M., Biological Chemistry 390, 373-377 (2009) PMID: 19090718

           

          24. S(1)?and S(2)?Subsite Specificities of Human Plasma Kalikrein and Tissue Kallikrein 1 on the Hydrolysis of Peptides Derived from Bradykinin Domain of Human Kininogen., Lima, A.R., Alves, F.M., Angelo, P.F., Andrade, D., Blaber, S.I., Blaber, M., Juliano.L. and Juliano, M.A., Biological Chemistry 389, 1487-1494 (2008) PMID: 18844446

           

          23. Protease Activated Receptor Dependent and Independent Signaling by Kallikreins 1 and 6 in CNS Neuron and Astroglial Cell Lines, Vandell, A.G., Larson, N., Laxmikanthan, G., Panos, M., Blaber, S.I., Blaber, M. and Scarisbrick, I.A., J. Neurochem. 107, 855-870 (2008) PMID: 18778305

           

          22. Activation Profiles of Human Kallikrein-related Peptidases by Proteases of the Thrombostasis Axis, Yoon, H., Blaber, S.I., Evans, D.M., Trim, J., Juliano, M.A., Scarisbrick, I.A. and Blaber, M. Prot. Sci. 17, 1998-2007 (2008) PMID: 18697857

           

          21. Kallikreins are Associated with Secondary Progressive Multiple Sclerosis and Promote Neurodegeneration, Scarisbrick, I.A., Linbo, R., Vandell, A.G., Keegan, M., Blaber, S.I., Blaber, M., Sneve, D., Lucchinetti, C.F., Rodriguez, M. and Diamandis, E., Biol. Chem. 389, 739-745 (2008) PMID: 18627300

           

          20. Substrate Specificity of Human Kallikreins 1 and 6 Determined by Phage Display, Li, H.-X., Hwang, B.-Y., Laxmikanthan, G., Blaber, S.I., Blaber, M., Golubkov, P.A., Ren, P., Iverson, B.L. and Georgiou, G. Protein Science 17, 664-672 (2008) PMID: 18359858

           

          19. Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S.I., Rodriguez, A., Kogot, J.M., Scarisbrick. I.A. and Blaber, M., J. Biol. Chem. 282, 31852-31864 (2007) PMID: 17823117

           

          18. Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N- and C-terminus b-strand Interactions, Dubey, V.K., Lee, J., Somasundaram, T., Blaber, S. and Blaber, M., J. Mol. Biol. 371, 256-268 (2007) PMID: 17570396

           

          17. The Autolytic Regulation of Human Kallikrein-Related Peptidase 6, Blaber, S., Yoon, H., Scarisbrick, I.A., Juliano, M.A., and Blaber, M. Biochemistry 46, 5209-5217 (2007) PMID: 17417874

           

          16. Dynamic Role of Kallikrein 6 in Traumatic Spinal Cord Injury, Scarisbrick, I.A., Sabharwal, P., Blaber, S.I., Cruz, H., Ameednuddin, S., Papke, L.M., Larsen, N., Fehlings, M.G., Reeves, R.K., Blaber, M., Windebank, A.J. and Rodriguez, M., Eur. J. Neurosci. 24, 1457-1469 (2006) PMID: 16987227

           

          15. Proteinase-activated Receptors, Targets for Kallikrein Signalling, Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I.A., Andrade-Gordon, P., Cottrell, G.S., Bunnett, N.W., Diamandis, E.P. and Hollenberg, M.D., J. Biol. Chem. 281, 32095-32112 (2006) PMID: 16885167

           

          14. Potential Scope of Action of Tissue Kallikreins in CNS Immune-Mediated Disease, Scarisbrick, I.A., Blaber, S.I., Tingling, J.T., Rodriguez, M., Blaber, M, and Christophi, G.P., J. Neuroimmunol. 178, 167-176 (2006) PMID: 16824622

           

          13. Kallikrein-Mediated Cell Signaling: Targeting Proteinase-Activated Receptors (PARs)1, Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Vergnolle, N., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I., Diamandis, E.P. and Hollenberg, M.D. Biological Chemistry 387, 817-824 (2006) PMID: 16800746

           

          12. Substrate Specificity of Human Kallikrein 6: Salt and Glycosaminoglycan Activation Effects, Angelo, P.F., Lima, A.R., Alves, F.M., Juliano, L., Blaber, S.I., Scarisbrick, I.A., Blaber, M. and Juliano, M.A. J. Biol. Chem. 281, 3116-3126 (2006) PMID: 16321973

           

          11. 1.70?/span> X-ray Structure of Human Apo Kallikrein 1: Structural Changes upon Peptide Inhibitor/substrate Binding, Laxmikanthan, G., Blaber, S.I., Bernett, M.J., Scarisbrick, I.A., Juliano, M.A. and Blaber, M., Proteins 58, 802-814 (2005) PMID: 15651049

           

          10. Distinct Promoters Regulate Tissue-specific and Differential Expression of Kallikrein 6 in CNS Demyelinating Disease, Christophi, G.P., Isackson, P.J., Blaber, S., Blaber, M., Rodriguez, M. and Scarisbrick, I.A. Journal of Neurochemistry 91, 1439-1449 (2004) PMID: 15584920

           

          9. Targeting Kallikrein 6 Proteolysis Attenuates CNS Inflammatory Demyelinating Disease, Blaber, S., Ciric, B., Bernett, M., Blaber, M., Rodriguez, M. and Scarisbrick, I.A., FASEB J. 18, 920-922 (2004) PMID: 15033932

           

          8. Activity of a Newly Identified Serine Protease in Oligodendrocyte Biology and Demyelination, Scarisbrick, I.A., Blaber, S.I., Lucchinetti, C.F., Genain, C.P., Blaber, M. and Rodriguez, M.. Brain 125, 1-14 (2002) PMID: 12023317

          7. Crystal Structure and Biochemical Characterization of Human Kallikrein 6 Reveals a Trypsin-like Kallikrein is Expressed in the Central Nervous System, Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M., and Blaber, M. J. Biol. Chem 277, 24562-24570 (2002) PMID: 11983703

          6. Alternative Type I and I' Turn Conformations in the b8/b9 b-hairpin of Human Acidic Fibroblast Growth Factor, Kim, J., Blaber, S.I.. and Blaber, M. Protein Science 11, 459-466 (2002) PMID: 11847269

          5. Enzymatic Properties of Rat Myelencephalon Specific Protease, Blaber, S.I., Scarisbrick, I.A., Bernett, M.J., Dhanarajan, P., Seavy, M.A., Jin, Y., Schwartz, M.A., Rodriguez, M. and Blaber, M. Biochemistry 41, 1165-1173 (2002) PMID: 11802715

          4. Structure and Stability Effects of Mutations Designed to Increase the Primary Sequence Symmetry within the Core Region of a b-Trefoil , Brych, S.R., Blaber, S.I., Logan, T.M. and Blaber, M., Protein Science 10, 2587-2599 (2001) PMID: 11714927

          3. Reduction of Wobble-position GC Bases in Corynebacteria Genes and Enhancement of PCR and Heterologous Expression, Sanli, G., Blaber, S.I. and Blaber, M. Journal of Molecular Microbiology and Biotechnology 3, 123-126 (2001) PMID: 11200224

          2. Thermodynamic Characterization of Mutants of Human FGF-1 with an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, A. and Blaber, M. Biochemistry 39, 7153-7158 (2000) PMID: 10852713

          1. Preferential Expression of Myelencephalon Specific Protease by Oligodendrocytes of the Adult Rat Spinal Cord White Matter, Scarisbrick, I.A., Asakura, K., Blaber, S., Blaber, M., Isackson, P.J., Bieto, T., Rodriguez, M. and Windebank, A.J. Glia 30, 219-230 (2000) PMID: 10756072

           

          Book chapters and other publications (5 total)

           

          5. Solvent Structure in the Active Site of Human Kallikrein 1, Laxmikanthan, G., Blaber, S.I., Scarisbrick, I.A. and Blaber, M., Hydrogen- and Hydration-Sensitive Structural Biology, Niimura, N., Mizuno, H., Helliwell, J. and Westhof, E., Eds., Kubapro, Co. Ltd Publishers, Tokyo Japan (2005) Ch. 3-6, 175-183

           

          4. Myelencephalon-specific Protease, Scarisbrick, I.A., Blaber, S. and Blaber, M., Handbook of Proteolytic Enzymes, 2nd Ed., Vol 1-2, pp1587-1590, Barrett, A.J., Rawlings, N.D., and Woessner, J.F., Eds., Elsevier Ltd., London (2003)

          3. Denaturation Studies of Human Acidic Fibroblast Growth Factor, Adamek, D., Popovic, A., Blaber, S. and Blaber, M. Biocalorimetry: Applications of Calorimetry in the Biological Sciences, John Wiley & Sons, Ladbury, J.E. and Haq, I., Eds. (1998) Chapter 16, pp 235-241

          2. Contribution of Free Cysteine Residues to the Stability of Human Acidic Fibroblast Growth Factor, Popovic, A., Adamek, D., Blaber, S. and Blaber, M. Biocalorimetry: Applications of Calorimetry in the Biological Sciences, John Wiley & Sons, Ladbury, J.E. and Haq, I., Eds. (1998) Chapter 20, pp 277-282

          1. Biophysical and Structural Analysis of Human Acidic Fibroblast Growth Factor, Blaber, M., Adamek, D.H., Popovic, A. and Blaber, S.I. Techniques in Protein Chemistry VIII, Academic Press, Marshak, D.R., Ed. 745-753 (1997)

           

          Abstracts (64 total)

           

          64. Kallikrein 6 promotes neurotoxicity by activating protease activated receptors, Yoon, H., Radulovic, M., Wu, J., Blaber, S.I., Blaber, M., Fehlings, M.G., Scarisbrick, I.A. (2013). 5th International Symposium on Kallikreins and Kallikrein Related Peptidases Toronto, CA. Third Place Platform Presentation Award

           

          63. Kallikrein 6 mediates therapy resistance in glioblastoma,.Drucker KL, Paulsen AR, Giannini C, Decker, P.A., Blaber, S.I., Blaber, M., Jenkins, R.B., Scarisbrick, I.A., 5th International Symposium on Kallikreins and Kallikrein-Related Peptidases, Toronto, CA. (2013) First Place Poster Award

           

          62. Kallikrein 6 signals through PAR1 and PAR2 to promote neurotoxicity and exacerbate glutamate-mediated excitotoxicity, Yoon, H., Radulovic, M., Wu, J., Blaber, S.I., Blaber, M., Fehlings, M.G. and Scarisbrick, I.A.,?FASEB J., 27(1_MeetingAbstracts): p. 662.20 (2013)

           

          61. Changes in Kallikrein 6-Related Peptidase in Severe, Moderate, and Mild Models of Traumatic Brain Injury, Phipps, H., Suber, J.F., Marin, V., Blaber, S.I., Blaber, M. and VanLandingham, J.W., National Neurotrauma Symposium, C54 (2012)

           

          60. The rise and fall of kallikrein 6 in traumatic brain injury, Phipps, H. W., Jackson, S., Suber, J., Levenson, C.W., Blaber, S.I., Blaber, M. and Vanlandingham, J., J. Head Trauma Rehab. 26, 426 (2011)

           

          59. Immunopathophysiological roles of kallikreins in CNS inflammatory disease, Scarisbrick, I.A., Renner, D.N., Blaber, S., Blaber, M., Yoon, H., Vandell, A.G. and Paulsen, A.R., 4th International Symposium on Kallikreins and Kallikrein-related Peptidases, 31 (2011)

          58. Functional intersection of matrix metalloproteases with kallikrein-related peptidases, Blaber, M., Blaber, S., Yoon, H. and Scarisbrick, I.A., 4th International Symposium on Kallikreins and Kallikrein-related Peptidases, 27 (2011)

          57. Role of kallikrein-related peptidase 6 in atrogliosis, Radulovic, M., Burda, J. Drucker, K., Blaber, S., Blaber, M., Yoon, H., Vandell, A.G., Paulsen, A.R. and Scarisbrick, I.A., 4th International Symposium on Kallikreins and Kallikrein-related Peptidases, 69 (2011)

          56. Human pro-KLK4 activation, revisited, Blaber, S., Li, W., Yoon, H., Scarisbrick, I.A., and Blaber, M., 4th International Symposium on Kallikreins and Kallikrein-related Peptidases, 83 (2011)

          55. Salt and glycosaminoglycan effects on substrate specificity of human kallikrein 3 (hKLK3) and 13 (hKLK13), Andrade, d., Lima, A.R., Assis, D.M., Angelo, P.F., Alves, F.M., Blaber, S.I., Blaber, M., Juliano, M.A. and Juliano, L., 3rd International Symposium on Kallikreins & Kallikrein-related Peptidases, 47 (2009)

           

          54. Structural biology and enzymology of the human kallikrein-related peptidases, Blaber, M., Yoon, H., Lee, J., Scarisbrick, I.A., Debela, M., Goettig, P. and Blaber, S., 3rd International Symposium on Kallikreins & Kallikrein-related Peptidases, 25 (2009)

           

          53. Kallikrein mediated signaling in CNS neurons and astrocytes, A. G. Vandell, J. E. Burda, N. Larson, J. Wu, P. Angelo, S. I. Blaber, M. Blaber, Scarisbrick, I. A. Society for Neuroscience (2009)

           

          52. Association of Kallikreins with Neuron Loss and Progressive Multiple Sclerosis, Linbo, R.A., Vandell, A.G., Larson, N.S., Keegan, M.B., Blaber, S.I., Blaber, M., Sneve, D.M., Lucchinetti, C.F., Rodriguez, M., Diamandis, E.P. Scarisbrick, I.A., 133rd American Neurological Association Meeting, Utah (2008)

          51. The autolytic regulation of human kallikrein-related peptidase 6 is negative feedback inhibition, Blaber, S., Yoon, H., Scarisbrick, I., Juliano, M., and Blaber, M., Protein Science, 17 (suppl. 1), 97 (2008)

          50. Activation profiles and regulatory cascades of the human kallikrein-related peptidases, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S., Rodriguez, A., Kogot, J. and Blaber, M., Protein Science, 17(suppl. 1), 96 (2008)

          49. The autolytic regulation of human kallikrein-related peptidase 6 is negative feedback inhibition, Blaber, S.I., Yoon, H., Scarisbrick, I.A., Juliano, M.A., and Blaber, M. 2nd International Symposium on Kallikreins & Kallikrein-related Peptidases, 57 (2007)

          48. The first screening method to identify potential activation for the human kallikrein family, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S.I., Rodriguez, A., Kogot, J.M., Scarisbrick, I.A., and Blaber, M., 2nd International Symposium on Kallikreins & Kallikrein-related Peptidases, 54 (2007)

          47. Multiple human tissue Kallikreins are regulated by lympho-epithelial Kazal-type inhibitor and digest desmoglein 1, Borgono, C. A., Michael, I. P., Komatsu, N., Sotiropoulou, G., Jayakumar, A., Wu, H., Clayman, G. L., Blaber, S. I., Blaber, M., Mikolajczyk, S. D., Diamandis, E. P., Journal Of Investigative Dermatology 126: 60-60 359 Suppl. 1 (2006)

          46. 1.70?X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding, Laxmikanthan, G., Blaber, S.I., Bernett, M.J., Scarisbrick, I.A., Juliano, M.A. and Blaber, M., 1st International Symposium on Kallikreins, 45 (2005)

          45. Kallikreins and cell signaling: differential regulation of proteinase-activated receptors (PARS), Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Vergnolle, N., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I., Diamandis, E.P., and Hollenberg, M.D., 1st International Symposium on Kallikreins, 53 (2005)

          44. A novel method to characterize the activation of serine proteases using hybrid bait protein, Laxmikanthan, G., Kogot, J., Blaber, S.I. and Blaber, M. Prot. Sci. 14(suppl. 1):167 (2005)

          43. Tissue-specific expression and differential regulation of multiple kallikrein 6 transcripts in CNS demyelinating disease,.Christophi, G.P., Isackson, P.J., Blaber, S.I., Blaber, M., Rodriguez, M. and Scarisbrick, I.A. 36th Annual Soc. Neurosci. 936.12 (2004)

          42. 1.7?X-ray structure of apo human kallikrein 1: Evidence for an induced-fit basis of dual substrate specificity, Laxmikanthan, G., Blaber, S.I., Bernett, M.J., Scarisbrick, I.A., Juliano, M.A. and Blaber, M. Gordon Research Conference, Proteolytic Enzymes and Their Inhibitors (2004 )

          41. Cloning of the human kallikreins, Frost, N.A., Blaber, S.I., and Blaber, M., FLACS LVI, 19 (2003)

          40. Expanded substrate specificity of human kallikrein 6 (hK6), Bernett, M.J., Blaber, S.I., Somasundaram, T. and Blaber, M., FLACS LVI, 18 (2003)

          39. Molecular insights on substrate specificity of human kallikrein 1, Laxmikanthan, G., Blaber, S., Bernett, M. and Blaber, M., FLACS LVI, 17 (2003)

          38. Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a b-trefoil, Brych, S., Blaber, S., Logan, M. and Blaber, M., Protein Science 11 (suppl. 1), 218 (2002)

          37. Crystal structure and biochemical characterization of human kallikrein 6 reveals a trypsin-like kallikrein is expressed in the central nervous system, Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M. and Blaber, M., Protein Science 11 (suppl. 1), 137 (2002)

          36. Alternative type I and I' turn conformations in the b8/b9 b-hairpin of human acidic fibroblast growth factor, Kim, J., Blaber, S.I. and Blaber, M., Protein Science 11 (suppl. 1), 80 (2002)

          35. Enzymatic properties of rat myelencephalon-specific protease, Blaber, S., Scarisbrick, I., Dhanarajan, P., Bernett, M., Schwartz, M., Seavy, M., Rodriguez, M., Jin, Y. and Blaber, M., Protein Science 11 (suppl. 1), 59 (2002)

          34. Crystal structure and biochemical characterization of human kallikrein 6 reveals a trypsin-like kallikrein is expressed in the central nervous system, Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M. and Blaber , M. Gordon Research Conference, Proteolytic Enzymes and Their Inhibitors (2002 )

          33. Crystal packing effects upon protein structure determined by x-ray crystallography, Blaber, M., Kim, J. and Blaber, S.., Abstracts of Papers of the American Chemical Society 223, 166-IEC Part 1 (2002)

          32. Role of a newly identified serine protease in immune-mediated demyelination, Scarisbrick I.A., Blaber S.I., Blaber M., Rodriguez M., FASEB Journal 16, A591-A591 Part 1 (2002)

          31. Alterations in Structure, Stability and Folding Kinetics Associated with an Increase in Internal Symmetry in Human Fibroblast Growth Factor 1, Brych, S., Blaber, S.I., and Blaber, M. Protein Science 10 (suppl. 2), 182 (2001)

          30. Expression, Purification and in vitro Characterization of Myelencephalon Specific Protease (MSP), a Novel Serine Protease Expressed in Mammalian Central Nerve System, Blaber, S.I., Dhanarajan, P., Scarisbrick, I.A., Seavy, M., Jin, Y. and Blaber, M. Protein Science 10 (suppl. 2), 161 (2001)

          29. Alternate Conformations in the beta 8/beta 9 Loop of Human Fibroblast Growth Factor 1, Kim, J., Blaber, S.I., Brych, S. and Blaber, M. Protein Science 10 (suppl. 2), 74 (2001)

          28. Expression, Purification and in vitro Characterization of Myelencephalon Specific Protease (MSP), A Novel Serine Protease Expressed in Mammalian Central Nerve System, Blaber, S., Bernett, M.J., Dhanarajan, P., Scarisbrick, I.A., Seavy, M., Jin, Y. and Blaber, M. Southeast Nerve Net, 17th Annual Meeting (2001)

          27. Structural Biology of the Mouse Glandular Kallikrein Family of Proteases, Kim, J., Blaber, S.I. and Blaber, M. Proc. 8th Intl. Conf. Crystal. Biol. Macromol., 165 (2000)

          26. A His-tagged form of Human Acidic Fibroblast Growth Factor with Enhanced Crystallographic Properties, Blaber, S.I. and Blaber, M. Proc. 8th Intl. Conf. Crystal. Biol. Macromol., 121 (2000)

          25. Structural Changes Associated with Mutations Designed to Probe the Role of a Symmetric Core-packing Arrangement in Human Acidic FGF, Brych, S.R., Blaber, S., Khurana, A., Blaber, M. Proc. 8th Intl. Conf. Crystal. Biol. Macromol., 102 (2000)

          24. The Role of Post-translational Modification on the Enzyme Activity of Mouse Glandular Kallikreins, Kim, J., Blaber, S.I., and Blaber, M. Protein Science 9 (Suppl.1) 110 (2000)

          23. Structure and Stability Effects of Cavity Reducing and Core Packing Mutants in Human Fibroblast Growth Factor I, Brych, S.R., Blaber, S.I., Khurana, S. and Blaber, M. Protein Science 9 (Suppl.1) 108 (2000)

          22. The Effects of Cysteine Mutations on the Stability of Human Acidic FGF, Culajay, J.F., Blaber, S.I., Khurana, A. and Blaber, M. Protein Science 9 (Suppl.1) 100 (2000)

          21. Increased Stability of Human FGF-1 Against Thermal Denaturation by Sulfate and Phosphate Binding, Whitten, S.T., Blaber, S.I., and Blaber, M. Protein Science 9 (Suppl.1) 94 (2000)

          20. Reversible Thermal Denaturation of Human FGF-1 Induced by Low Concentrations of Guanidine HCl, Blaber, S. I., Culajay, J.F., Khurana, A. and Blaber, M., Proceedings of the Gibbs Symposium (2000)

          19. Structure and Stability Effects of Mutations Designed to Probe the Role of a Symmetric Core-packing Arrangement in Human Acidic FGF, Brych, S.R., Blaber, S., Khurana, S., Khurana, A. and Blaber, M. Proceedings of the54th Calorimetry Conference, 147 (1999)

          18. Thermodynamic Characterization of Mutants of Human FGF-1 that have an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, S., Khurana, A., Kennedy, D., Williams, K. and Blaber, M. Proceedings of the54th Calorimetry Conference, 150 (1999)

          17. Construction and Characterization of a Synthetic 2,5-Diketo-D-Gluconate Reductase Gene, Sanli, G., Blaber, S., Khurana, S. and Blaber, M. Proceedings of the54th Calorimetry Conference, 164 (1999))

          16. Thermodynamic Characterization of Mutants of Human FGF-1 that have an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, S., Khurana, A., Kennedy, D. and Blaber, M. Protein Science 8, 95 (1999)

          15. The Role of Low Concentrations of Guanidine HCl in Reversible Thermal Denaturation of Human FGF-1, Blaber, S.I., Culajay, J.F., Khurana, A. and Blaber, M. Protein Science 8, 96 (1999)

          14. Construction and Characterization of a Synthetic Gene for 2,5-Diketo-D-Gluconate Reductase, Sanli, G., Blaber, S., Khurana, S. and Blaber, M. Protein Science 8, 65 (1999)

          13. The Role of Low Concentrations of Guanidine HCl in Reversible Thermal Denaturation of Human Fibroblast Growth Factor-1, Blaber, M., Blaber, S.I., Culajay, J.F., and Khurana, A. FLACS 52, 10 (1999)

          12. Construction and Characterization of a Synthetic Gene for 2,5-Diketo-D-Gluconate Reductase, Sanli, G., Blaber, S., Khurana, S. and Blaber, M. FLACS 52, 49 (1999)

          11. The Role of Low Concentrations of Guanidine HCl in Reversible Denaturation of Human Acidic Fibroblast Growth Factor-1, Blaber, S.I., Culajay, J.F., Khurana, A. and Blaber, M. Biophysical Journal, 76, A107 (1999)

          10. Cysteine Residue Mutations in Human Acidic FGF and Effects upon Thermal Stability, Culajay, J.F., Blaber, S.I. and Blaber, M. FLACS 51, 44 (1998)

          9. Structural Influence on Specificity and Catalytic Behavior in Serine Proteases, Badisa, R.B., Blaber, S.I. and Blaber, M. FLACS 51, 44 (1998)

          8. Effects of Low Concentrations of Guanidine Hydrochloride on the Stability and Reversible Denaturation of Human Acidic Fibroblast Growth Factor, Blaber, S. and Blaber, M. Proceedings of the 3rd Annual Johns Hopkins Protein Folding Meeting (1998)

          7. An approach to accurate DSC analyses of irreversibly unfolding proteins, Adamek, D., Blaber, S., Culajay, J.F. and Blaber, M. FLACS 50, 59 (1997)

          6. Contribution of the cysteine residues to the thermal and physiological stability of the human acidic fibroblast growth factor, Culajay, J.F., Blaber, S., Adamek, D., Khurana, S. and Blaber, M. FLACS 50, 59 (1997)

          5. Mechanisms of Regulation of Human Acidic Fibroblast Growth Factor, Blaber, M., Adamek, D., Blaber, S., Culjay, J. and Khurana, S. 20th Annual Research Seminar American Cancer Society, Florida Division (1997)

          4. Avoiding the Aggravation of Aggregation: Denaturation Studies of Acidic Fibroblast Growth Factor, Adamek, D., Grek, S., Blaber, S. and Blaber, M. Proceedings of the 5th Annual Suddath Symposium (1997)

          3. The Use of Low Concentration Guanidine Hydrochloride to Achieve Reversible Thermal Denaturation of Acidic Fibroblast Growth Factor, Adamek, D., Blaber, S. and Blaber, M. Proceedings of the 2nd Annual Johns Hopkins Protein Folding Meeting (1997)

          2. Denaturation Studies of Human Acidic Fibroblast Growth Factor, Adamek, D., Popovic, A., Blaber, S. and Blaber, M. First International Conference on the Applications of Biocalorimetry, R-01 (1996)

          1. Contribution of Free Cysteine Residues to the Stability of Human Acidic Fibroblast Growth Factor, Popovic, A., Adamek, D., Blaber, S. and Blaber, M. First International Conference on the Applications of Biocalorimetry, P-19 (1996)

           

           

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