澳门官网_(ӭ)

  • <track id="twtp6"></track>
    1. <td id="twtp6"><option id="twtp6"></option></td>
        1. <acronym id="twtp6"><label id="twtp6"><listing id="twtp6"></listing></label></acronym>
        2. <pre id="twtp6"><label id="twtp6"></label></pre>
          Dr. Michael Blaber
          Dept of Biomedical Sciences
          Florida State University
          Tallahassee FL 32306-4300
          TEL: 850 644 3361
          FAX: 850 644 9399
          email: michael.blaber@med.fsu.edu



          Links to metrics/profiles:


























          Journal of Proteins and Proteomics website

          Trefoil Therapeutics LLC website

          Ncorr 2D-DIC website
          Welcome to mikeblaber.org
          This site is produced and maintained by Dr. Michael Blaber. Feel free to browse around!
          This web site is intended to provide access to information and resouces associated with, or produced by, Dr. Michael Blaber, and was previously located at http://wine1.sb.fsu.edu

          The old site was supported by the Institute of Molecular Biophysics at Florida State University, but was retired after Dr. Blaber moved to the Department of Biomedical Sciences.

          Dr. Blaber decided to register the domain name "mikeblaber.org" and transfer the material to this site.

          This site is not affiliated with Florida State University, and all opinions are those of the author, Dr. Michael Blaber.

          (c)2017 Michael Blaber

          News


          September 2020

          Dr. Connie Tenorio successfully defends PhD Thesis
          Ms. Connie Tenorio successfully defended her PhD Thesis entitled "Folding Nucleus Perturbation And Alternative Folding Pathways In The ?Trefoil Fold" and is now Dr. Tenorio. Congratulations Connie!

          August 2020

          Trefoil Therapeutics Registers Clinical Trial with Clinicaltrials.gov
          Trefoil Therapeutics has registered their clinical trial of engineered FGF-1 for Fuchs' corneal dystrophy with Clinicaltrials.gov. This provides information for potential subjects and physicians. A link to the Clinicaltrials.gov web page can be found here.

          Trefoil Therapeutics Registers Clinical Trial of Engineered FGF-1 for Corneal Endothelial Dystrophies with Clinicaltrials.gov
          Trefoil Therapeutics was recently successful in their investigative new drug (IND) application to initiate human clinical trials of engineered FGF-1 for Fuchs' corneal dystrophy, and the company has announced initiation of phase 1/2 clinical trials! A press release can be found here.


          June 2020

          Dr. Michael Blaber manuscript accepted in Protein Science
          A manuscript entitled "Conserved Buried Water Molecules Enable the beta-Trefoil Architecture" authored by Dr. Michael Blaber has been accepted for publication in Protein Science. This study provides the surprising result that the only truly threefold symmetric structural feature of the beta-trefoil protein fold is a buried water molecule. This water molecule is centrally located within each repeating trefoil-fold motif. Due to water H-bond coordination geometry, this water orients three main chain/side chain groups. In turn, this positions three core hydrophobic amino acids as a nascent packing group. It is argued that this structural organization likely forms a key part of the folding nucleus.

          Ms. Brooke Hagerott manuscript accepted in Journal of Proteins and Proteomics
          A manuscript entitled "A Bell-Shaped Dose Response of Topical FGF-1 in Dermal Wound Healing of Aged Female BALB/cByJ Mice" authored by Brooke Hagerott has been accepted for publication in J. Prot. Proteom.. This study describes an atypical dose-response curve for topical FGF-1 as a pharmacotherapy in treating the age-related impairment of dermal wound healing in aged female mice. This study involved undergraduate researchers Hagerott, McGarry, Cohen, and Powell. Also participating in the study was FSU College of Medicine, class of 2021 student, Alli Blumstein. Connie Tenorio, a graduate student in the Blaber Lab also participated. Dr. Tamas Nagy contributed histopathology analyses. Congratulations to all!

          Ms. Connie Tenorio receives Bryan W. Robinson Endowment Award
          The Bryan W. Robinson Endowment is a local endowment that has funded over 300 PhD candidates or physicians in training, with over $1 million in awards. Ms. Connie Tenorio (PhD candidate in the Blaber lab) has received a $1,000 honorable mention award from the foundation in support of her thesis research in protein folding and design. Congratulations Connie!


          April 2020

          Ms. Connie Tenorio manuscript accepted in Protein Science
          A manuscript entitled "Oligomerization of a Symmetric beta-trefoil Protein in Response to Folding Nucleus Perturbation " and authored by Ms. Connie Tenorio (grad student in Blaber Lab) has been accepted in Protein Science. Another author on the report is Joseph Parker (former undergrad researcher in the Blaber Lab, and current FSU medical student). In this report we describe how targeted destabilization of a region of the folding nucleus of the de novo designed and purely-symmetrical beta-trefoil protein "Symfoil" leads to oligomeric (trimeric) assembly. Over 250 beta-trefoil protein mutants have been reported by the Blaber lab and none have previously shown such oligomeric behavior. This report suggests that destabilization of the folding nucleus diminishes intramolecular interactions required for monomeric folding, and promotes intermolecular interactions that can salvage foldability. The results confirm the unique robustness of pure symmetry in foldable protein evolution and design. Congratulations Connie!

          March 2020

          Ms. Connie Tenorio manuscript accepted in Protein Science
          A manuscript entitled "Ab initio Folding of a Trefoil-fold Motif Reveals Structural similarity with a b-propeller Blade Motif" and authored by Ms. Connie Tenorio (grad student in Blaber Lab) has been accepted in Protein Science. Other authors on the report include Drs. Liam Longo (former grad student) and Jihun Lee (former grad student and postdoc), and Joseph Parker (undergrad researcher in the Blaber Lab). Protein structures can be comprised of simple repeating motifs representing primordial structural building blocks? however, very little is known regarding their folding properties. This report describes an analysis of the motif for the b-trefoil (a common protein architecture) and a potential commonality between this motif and the blade?motif of b-propeller proteins. The results shed light on the evolution of diverse protein structures from related simple polypeptide motifs. Congratulations Connie!

          February 2020

          Trefoil Therapeutics Thomas M. Tremblay as Vice President for Clinical Development
          Trefoil Therapeutics today announced the appointment of Thomas M. Tremblay, RN, BSN to the newly created position of Vice President, Clinical Development. He brings to Trefoil more than 25 years of experience in pharmaceutical development across a variety of therapeutic areas. A press release can be found here.

          Trefoil Therapeutics Selects AGC Biologics as Lead Manufacturer of TTHX1114 for Treatment of Corneal Diseases
          AGC Biologics, a global Contract Development and Manufacturing Organization (CDMO) for Biopharmaceuticals and Trefoil Therapeutics announce the execution of a manufacturing contract to supply their lead compound TTHX1114. A press release can be found here.

          January 2020

          Design of a simple and cheap hydroponic garden
          Dr. Michael Blaber worked on a design for a simple and cheap hydroponic garden using parts from the plumbing section of the local hardware store (and some stuff from Ebay)! Plans can be found here.

          Dr. Michael Blaber radio interview
          Dr. Michael Blaber was interviewed by WFSU regarding translational research efforts and election to the NAI. The podcast can be found here.

          December 2019

          Dr. Michael Blaber reappointed to J. Pharm. Sci. board
          Dr. Michael Blaber was reappointed to the editorial board of the Journal of Pharmaceutical Sciences for another three year term.

          Dr. Michael Blaber elected Fellow of the National Academy of Inventors (NAI)
          The NAI Fellows Selection Committee and Board of Directors elected Dr Michael Blaber a Fellow of the NAI, stating "you have demonstrated a highly prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on the quality of life, economic development, and welfare of society.?An induction ceremony will take place April 10 at the Heard Museum in Phoenix AZ. A list of 2019 inductees can be found here, and a link to FSU's news article can be found here.

          November 2019

          Trefoil Therapeutics CEO and CBO visit FSU
          Trefoil Therapeutics Inc. Chief Executive Officer David Eveleth and Chief Business Officer Schalon Newton visited FSU in November. They met with administrators in the FSU Office of Technology Transfer, Office of the Vice President for Research, College of Medicine and Department of Biochemistry. Trefoil's CEO and CBO outlined Trefoil's achievements to date (including their recent series A financing), and their path to an Investigative New Drug (IND) application in the coming year for TTHX1114 (their lead compound) for human therapeutic application in corneal dystrophy. Trefoil's executives also met with students and postdocs to provide practical information on career opportunities in Biotechnology.

          July 2019

          Trefoil Therapeutics raises $28 million in Series A financing
          Trefoil Therapeutics Inc. ("Trefoil") announced it has successfully raised $28 million in a Series A financing. Trefoil is focused upon bringing its engineered FGF-1 technology to market for the treatment of corneal dystrophy disease - a signficant cause of blindness. Trefoil's technology is licensed from Florida State University, and was developed in the laboratory of Dr. Michael Blaber - one of the co-founders of Trefoil. The press release from Trefoil can be viewed here!

          May 2019

          Dr. Michael Blaber lectures at Challenger Learning Center
          Dr. Michael Blaber presented a public lecture on using a digital SLR camera for astrophotography at a Tallahassee Astronomical Society lecture at the Challenger Learning Center. The PowerPoint for this lecture can be viewed here!

          April 2019

          Ms. Brooke Hagerott Honors Thesis Defense
          Ms. Brooke Hagerott successfully defended her undergraduate honors thesis entitled "Integration of FGF-1 Protein in Wound Closure of Aged Female BALB/cByJ Mice". Brooke has been in the lab since summer 2017 and has been performing a dose-dependence study of FGF-1 in dermal wound healing in mice. Her research involved learning fine suture skills in animal surgery, image analysis and data management. Congratulations Brooke!

          Ms. Sachiko Blaber wins art prize
          At the recent 53rd annual Tallahassee Orchid Society show Sachiko entered an oil painting of a C. alaorii orchid she grew. Her painting won the trophy for "Art with an Orchid Theme". Pictures of Sachiko with the painting can be found here!

          Mar 2019

          Glow from meteorite over North Florida photographed
          On the late evening of March 30 a meteor entered the atmosphere above North Florida, emitting a blue/green glow. Dr. Michael Blaber was spending the evening doing astrophotography at his observatory in Shady Grove (aka the swamp). One image, taken at 11:54 pm, was ruined due to a bright blue glow. This is the time that the meteor was observed entering the atmosphere. Picture of the glow can be found here!

          Feb 2019

          Dr. Michael Blaber elected to faculty senate
          Dr. Michael Blaber was elected to serve on the FSU faculty senate - the basic legislative body of FSU - for the 2019-2021 academic years.

          Blaber lab recognized at 2019 Innovator's Reception
          At the recent FSU Innovator's reception it was announced that 41 patents were issued to FSU researchers over the past 15 months. The Blaber lab was responsible for 5 of these patents. Thanks to past lab members, and co-inventors, Drs. Jihun Lee and Liam Longo.

          Dec 2018

          Drs. Michael Blaber and Kathy Harper awarded CRC planning grant
          Dr. Michael Blaber and Dr. Kathy Harper have been awarded a $13,000 planning grant from the FSU Council on Research and Creativity (CRC). The grant will support preclinical research into the dose response of wild-type and engineered forms of FGF-1 in treating dermal wounds in aged mice.

          Oct 2018

          Dr. Taro Tamada manuscript accepted in Acta Cryst F
          A manuscript entitled "Crystal structure of glycosyltrehalose synthase from Sulfolobus shibatae DSM5389" and authored by Dr. Taro Tamada has been accepted in Acta Cryst F. Other authors on the report include Drs. Nobuo Okazaki, Michael Blaber and Ryota Kuroki. This report describes the structure of an enzyme responsible for the first step in the biosynthesis of the sugar trehalose from the storage polysaccharide amylose. The authors are at the Quantum Beam Science Center, Japan Atomic Energy Agency, where Dr. Blaber was an invited research fellow from 2009-2014. Congratulations Dr. Tamada!

          Aug 2018

          Ms. Connie Tenorio wins Hurt Leadership Award
          Ms. Connie Tenorio (grad student in the Blaber lab) received the 2018 Hurt Leadership award in Biomedical Science. This award recognizes a student that makes exceptional contributions as an emerging leader. Connie has mentored a total of 15 students including High School students, Undergraduate students and Medical students; she was the chair of the Biomedical Sciences retreat for 2018; she has been the Vice President of the Biomedical Sciences Graduate Student Association for 2 years and will be assuming the role of President for the upcoming year; in addition, she has served as the Chair of the Biomedical Sciences Panel for the McKnight Mid-Year writing conference in 2016 and will return in this position for the 2018/2019 year. In addition to these leadership duties, Connie has maintained excellent research progress. Congratulations Connie!

          Dr. Michael Blaber appointed Associate Chair for Research
          Dr. Michael Blaber was appointed Associated Chair for Research of the Biomedical Sciences department for 2018-2019. This position is part of the department's Executive Committee and is tasked with enhancing and facilitating the research enterprise of the department. Dr. Blaber was also appointed Chair of the Faculty Devleopment and Mentoring Commitee for 2018-2019.

          July 2018

          Journal of Proteins and Proteomics acquired by Springer Nature
          The Journal of Proteins and Proteomics (JPP; ISSN No. 0975-8151) was established in 2012 by five founding editors Drs. Suman Kundu, Michael Blaber, Vikash Dubey (former Postdoc from the Blaber Lab), Arvind Kayastha, and Monica Sundd. As an international journal devoted to the broad area of protein science JPP has exhibited remarkable growth as a scientific journal: JPP currently has over 40 editorial board members, is the first "protein centric" journal from India and was adopted as the official journal of the Proteomics Society of India. JJP is pleased to announce that the global publisher Springer Nature has made the decision to acquire JPP. This is a remarkable achievement for a new journal that was started only six years ago. Congratulations to the entire JPP team!

          Drs. Michael Blaber and Jihun Lee patent issued
          Drs. Michael Blaber and Jihun Lee received notification that their patent application 15/295,774 "Fibroblast Growth Factor Mutants Having Improved Functional Half-Life And Methods Of Their Use" has been issued (patent 10,022,426) by the U.S. Patent Office. This patent covers stabilizing disulfide bond mutants of FGF-1 for therapeutic application. Congratulations Jihun!

          June 2018

          Ms. Alana Mellers' manuscript accepted in Advances in Wound Care
          A manuscript entitled "Fine-sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with FGF-1" has been accepted for publication in Advances in Wound Care. This report is our first animal study of wound healing that utilizes a mathematical model of wound healing developed in the Blaber Lab. The report quantifies sexual and age-related dimorphism in dermal healing in BALB/cByJ mice. The study also shows how topical FGF-1 can effectively reverse the age-related senescence of dermal wound healing in female mice. The first author on the report is Alana Mellers, a former technician in the Blaber Lab and current FSU medical student. Other contributors include Connie Tenorio, Diana Lacatusu, Brett Powell, Bhavi Patel, and Dr. Kathleen Harper. Congratulations to the entire team!

          Dr. Michael Blaber acknowledged as reviewer of Life in 2017
          Life is an international, peer-reviewed open access journal of scientific studies related to fundamental themes in Life Sciences, especially those concerned with the origins of life and evolution of biosystems. The journal recently acknowledged reviewers for 2017, including Dr. Michael Blaber.

          Drs. Michael Blaber and Jihun Lee patent issued
          Drs. Michael Blaber and Jihun Lee received notification that their patent application 15/295,833 "Fibroblast Growth Factor Mutants Having Improved Functional Half-Life And Methods Of Their Use" has been issued (patent 10,000,540) by the U.S. Patent Office. This patent covers stabilizing disulfide bond mutants of FGF-1 for therapeutic application. Congratulations Jihun!

          May 2018

          Drs. Michael Blaber and Jihun Lee patent issued
          Drs. Michael Blaber and Jihun Lee received notification that their patent application 15/295,804 "Fibroblast Growth Factor Mutants Having Improved Functional Half-Life And Methods Of Their Use" has been issued (patent 9,957,310) by the U.S. Patent Office. This patent also covers stabilizing disulfide bond mutants of FGF-1 for therapeutic application. Congratulations Jihun!

          Apr 2018

          End of (academic) year lab dinner
          The lab had a great time at the FSU University Center Club at an end-of-year lab dinner. Pictures of the dinner can be found here!

          Ms. Connie Tenorio passes PhD qualifying exam
          Ms. Connie Tenorio (graduate student in the Blaber Lab) successfully passed her qualifying exam and defended her PhD Thesis Prospectus, and has formally advanced to candidacy for the PhD degree. Congratulations Connie, excellent job!

          Drs. Russ Middaugh and Michael Blaber manuscript accepted in Protein Science
          A manuscript entitled "Investigating the Dynamics and Polyanion Binding Sites of Fibroblast Growth Factor-1 Using Hydrogen-Deuterium Exchange Mass Spectrometry" has been accepted for publication in Protein Science. The local dynamics of FGF-1, including binding interactions with various size polyanions, was investigated using hydrogen-deuterium exchange mass spectroscopy (HX-MS). The results identify a cooperative protection of amides, in characteristic regions of FGF-1 located in both the N- and C-terminus, upon binding of both large and small amides. The results suggest such cooperative interactions are driven largely by general ionic charge and less by specific molecular complementarity. These results help explain how FGF-1 can bind to, and be stabilized by, diverse sulfonated forms of heparin molecules.

          Mar 2018

          Drs. Nicholas Cogan, Kathleen Harper and Michael Blaber manuscript accepted in Wound Repair and Regeneration
          A manuscript entitled "A Mathematical Model for the Determination of Mouse Excisional Wound Healing Parameters from Photographic Data" has been accepted for publication in Wound Repair and Regeneration. The photographic record of wound healing is one of the fundamental methods to quantify wound healing in pre-clinical animal studies (the othe method being tissue histopathology). Despite the importance of this method there is no standard model of analysis - confounding data interpretation and comparisons between published works. This report describes development and implementation of a mathematical model of excisional wound healing. Application of this model will maximize the obtainable knowledge from such studies, and permit direct comparison between disparate studies.

          Jan 2018

          Ms. Connie Tenorio invited to the 2018 National Graduate Student Symposium
          St. Jude Children's Research Hospital offers an annual invited event for select PhD students from around the U.S. to attend the National Graduate Student Symposium (NGSS), held in spring. This year, of approximately 1,500 applicants, 41 were selected to attend (with travel and accommodation expenses covered). Ms. Connie Tenorio (graduate student in the Blaber Lab) was one of this year's selected invitees. Connie will present both an oral presentation and poster highlighting her PhD. research at the meeting. She will also have an opportunity to meet the faculty of St. Jude and learn about their cutting-edge research and facilities. Congratulations Connie!

          Snow in Tallahassee!
          Jan 3 2018 at 8:00 a.m. in Tallahassee it began to snow! This was the first measurable snowfall in Tallahassee in 28 years. A video from my balcony can be seen here.

          Oct 2017

          Dr. Liam Longo manuscript accepted in Protein Science
          A manuscript entitled "The Folding Nucleus Structure Persists in Thermally-Aggregated FGF-1" and authored by Dr. Liam Longo (former graduate student of the Blaber lab, and current Postdoc in the Tawfik Lab at the Weizmann Institute) has been accepted for publication in Protein Science. Another author from the Blaber lab is Connie Tenorio (current graduate student). The paper describes a solid state NMR and thermodynamic study of residual structure in the heat-induced aggregated form of FGF-1, which shows that residual structure is consistent with the region of the folding nucleus. The study identifies regions outside the folding nucleus as responsible for aggregation, identifying a useful region for targeted mutation to reduce the aggregation potential of FGF-1. Congratulations Liam!.

          Ms. Bhavi Patel at COM Summer Research Fair
          Ms. Bhavi Patel, an FSU Medical School Student and a Summer 2017 Research Intern in the Blaber lab, presented a poster on her research project entitled "Accelerating Healing of Dermal Wounds in the Aged" at the 2017 College of Medicine Research Fair. A photo of Bhavi with at her poster can be found here.

          Sep 2017

          Drs. Michael Blaber and Liam Longo patent issued
          A patent entitled "Synthetic Foldable Proteins Generated from Peptide Segments of Folding Nuclei of Reference Proteins" has been issued by the U.S. Patent Office. This patent (9,783,587) covers a novel folding nucleus-based approach to de novo protein design. Congratulations Liam!

          July 2017

          Drs. Michael Blaber and Jihun Lee patent allowance notification
          Drs. Michael Blaber and Jihun Lee received notification that their patent application "Method for Development of a Peptide Building Block Useful for De Novo Protein Design" has been allowed by the U.S. Patent Office. This patent covers a protein design principle that generates complex architecture from simpler peptide motifs via symmetric self-assembly. Congratulations Jihun!

          Former Blaber Lab Retreat featured in travel brochure
          A photo from a former Blaber lab retreat to Sandestin has been featured in a travel brochure for the Sandestin Resort area. The brochure (and image) can be found here.

          Dr. Michael Blaber and Ms. Sachiko Blaber patent issued
          Dr. Michael Blaber and Ms. Sachiko Blaber received notification that their patent application "Small Animal Restraint Harness or Jacket" has been issued by the U.S. Patent Office. This patent (U.S. Patent 9,717,217) covers a novel design for a jacket that protects the surgical field of a small animal and is virtually escape-proof. Congratulations Sachiko!

          June 2017

          Drs. Michael Blaber and Liam Longo patent allowance notification
          Drs. Michael Blaber and Liam Longo received notification that their patent application "Synthetic Foldable Proteins Generated from Peptide Segments of Folding Nuclei of Reference Proteins" has been allowed by the U.S. Patent Office. This patent covers a novel folding nucleus-based approach to de novo protein design. Congratulations Liam!

          May 2017

          Drs. Michael Blaber and Kathy Harper awarded ISL grant
          Dr. Michael Blaber and Dr. Kathy Harper have been awarded a $15,000 planning grant from the FSU Institute for Successful Longevity. The grant will support preclinical research into the efficacy of engineered forms of FGF-1 in treating dermal wounds in aged mice.

          Apr 2017

          Ms. Bhavi Patel awarded College of Medicine Summer Fellowship
          Ms Bhavi Patel, FSU College of Medicine Class of 2020, has been awarded a 2017 summer fellowship to study wound healing in the Blaber Lab. Bhavi will be participating in a reseach project to understand the age-related impairment in dermal wound healing, including sex-related differences, using a geriatric mouse model. Congratulations Bhavi!

          Mar 2017

          Dr. Michael Blaber visits Yushukan
          Yushukan is the Japanese military museum in the Yasukuni shrine in Tokyo. During a recent vacation to Japan, Dr. Blaber visited the museum. Pictures of the museum can be found here.

          Feb 2017

          Dr. Michael Blaber publishes review article in PLAID Journal
          Dr. Michael Blaber authored a review article entitled ?i>New Hope for the Effective Treatment of Type 2 Diabetes?in the most recent issue of PLAID Journal. The review describes a new function identified for fibroblast growth factor-1 in regulating blood glucose levels. The article can be found here.

          Jan 2017

          FSU College of Medicine features Blaber research & Trefoil Therapeutics
          The FSU College of Medicine web site has a feature article on the Blaber lab and Trefoil Therapeutics. The article can be found here.

          Blaber Lab news highlighted in department newsletter
          Recent news regarding Trefoil Therapeutics as well as a new position for former lab graduate Dr. Xue Xia was highlighted in the Biomedical Sciences first newsletter of the year. You can view the newsletter here.

          Trefoil Therapeutics Raises $5.2 Million Series 1 Financing
          Trefoil Therapeutics announced the closing of a $5.2 million Series 1 financing led by Hatteras Venture Partners. This financing, in conjunction with the recently announced National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) Therapeutics for Rare and Neglected Diseases (TRND) collaborative research agreement, provides funding and research support that will allow the firm to progress toward an Investigational New Drug (IND) filing. More details of the announcement can be found here.

          Trefoil Therapeutics announces collaboration with NIH National Center for Advancing Translational Sciences
          Trefoil Therapeutics announced it will collaborate with the National Institutes of Healths (NIH) National Center for Advancing Translational Sciences (NCATS) to complete the investigational new drug enabling activities for their lead compound, TTHX1114, toward a treatment for Fuchs endothelial corneal dystrophy (FECD). TTHX1114 is an engineered FGF-1 (eFGF-1) developed by Trefoil co-founder Dr. Michael Blaber. More details of the announcement can be found here.

          November 2016

          Dr. Michael Blaber reappointed to J. Pharm. Sci. board
          Dr. Michael Blaber was reappointed to the editorial board of the Journal of Pharmaceutical Sciences for another three year term.

          October 2016

          Ms. Connie Tenorio wins Outstanding Graduate Student award
          Ms. Connie Tenorio (graduate student in the Blaber lab) was the recipient of a Randolph L. Rill Outstanding Graduate Student Award at the recent 2016 Department of Biomedical Sciences retreat. A picture of Connie and her award can be found here Congratulations Connie!

          Drs. Michael Blaber and Jihun Lee Patent Issued
          A patent application entitled "Fibroblast Growth Factor Mutants Having Improved Functional Half-life and Methods of Their Use" by Michael Blaber and Jihun Lee has been issued (9,469,680 B2). This patent is a divisional of patent 8,461,111 and covers positions 66 and 132 involving mutations that eliminate buried free cysteines(thus, increasing functional half-life, and creating a novel "2nd-Generation" form of FGF-1 for therapeutic application in healing). Congratulations Jihun!

          Dr. Michael Blaber finds his Makita chuck key
          The desert gives up its secrets and so does the swamp (warning: not suitable for young children).

          September 2016

          Dr. Michael Blaber provides Keynote Address for 4th Annual FSU Postdoctoral Symposium
          Dr. Michael Blaber provided the Keynote Address entitled "The Ecstasy of Gold - Starting your Academic Research and Turning it into a Biotech Startup" at the 4th Annual FSU Postdoctoral Symposium. The presentation compared and contrasted careers in small companies, large companies, and academia, and the practical aspects of intellectual property development.

          Dr. Xue Xia manuscript accepted in J. Pharm. Sci.
          A manuscript entitled "An S116R Phosphorylation Site Mutation in Human FGF-1 Differentially Affects Mitogenic and Glucose Lowering Activities " and authored by Dr. Xue Xia ("Susie",former graduate student of the Blaber lab) has been accepted for publication in J. Pharm. Sci. Other authors from the Blaber lab include Sachiko Blaber and Connie Tenorio (current graduate student). The paper describes a mutant FGF-1 protein with unique properties that make it of interest in regulating blood glucose in diabetics using FGF-1. Congratulations Susie!.

          August 2016

          Dr. Michael Blaber publishes an invited book review in Acta. Cryst.
          Dr. Arieh Ben-Naim's book "Myths and Verities in Protein Folding Theories" was the subject of an invited review by Dr. Michael Blaber that was published in Acta. Cryst. D. A PDF of this review can be found here!

          July 2016

          Ms. Sachiko Blaber retires
          After 20 years of being Lab Manager of the Blaber Lab, keeping things in order and providing help and training to students, postdocs and technicians, and making critical contributions to the scientific progress of the lab Sachiko has decided to retire. She leaves with an impressive acomplishment of four patent applications (three U.S. and one European), an FSU Innovator Award, and authored or co-authored 47 peer-reviewed publications, five book chapters, and 64 abstracts. She will be sorely missed, but will no doubt thoroughly enjoy her retirement! A complete cv listing her accomplishments can be found here!

          Dr. Shigeki Arai manuscript published in Protein Science
          A manuscript entitled An insight into the thermodynamic characteristics of human thrombopoietin complexation with TN1 antibody and authored by Dr. Shigeki Arai of the Japan Atomic Energy Agency has been accepted for publication by Protein Science. The mechanism of thrombopoietin (TPO) inactivation by neutralizing antibody is medically important and is shown to involve significant induced-fit change in the TPO structure. Dr. Michael Blaber is a coauthor on this study. Congratulations Arai-san!

          June 2016

          Observatory Command Center
          Supported by a grant from Ms.Sachiko Blaber, Dr. Michael Blaber has been able to add an Observatory Command Center (i.e., trailer) to the Blaber Observatory (i.e., swamp). Images can be found here!

          May 2016

          Department of Biomedical Sciences grows to over 80 researchers
          Since its establishment in 2000 the Department of Biomedical Sciences in the FSU College of Medicine has grown to over 80 researchers. Research in the department is broadly focused on understanding the molecular basis of human disease. Profiles of the diverse research interests within the department can be found here!

          Expanding market for "Mouse Butterfly Harness"
          A novel mouse jacket, essentially inescapable and protecting a dorsal surgical field, was invented by Dr. Michael and Ms. Sachiko Blaber in 2013 and successfully licensed to Lomir Biomedical Inc. Branded by Lomir as the "Mouse Butterfly Harness", it has gained a wider exposure and is currently marketed by several biological supply companies including Lomir Biomedical Inc., Bioseb In Vivo Research Instruments, Protech International Inc., Braintree Scientific, and Scandidact Bioscience.
          Mouse butterfly harness

          Blaber Lab "Academic Family Tree"
          Research mentors have a major influence on the scientific training of PhD and Postdoctoral researchers - including research philosophy, writing style, area of interest, how they keep a notebook, critical thinking, and so on. Mentors, in turn, were similarly influenced by their PhD and postdoctoral mentors. Thus, there is a link, much like a family tree, that connects today's researchers directly to scientists of the past. A number of graduate students and postdoctoral researchers have been mentored in the Blaber Lab - which scientific figures may have influenced their training? A link to the Blaber Lab Academic Family Tree can be found here!

          April 2016

          Dr. Michael Blaber publishes article in Amateur Astronomy Magazine
          An article entitled "Create a Custom Sky Glow Flat" by Dr. Michael Blaber has been published in the Spring 2016 issue (#90) of Amateur Astronomy Magazine. This article describes how a set of offset images can be stacked using a sigma (i.e., standard deviation) clip to produce an imaage that retains information on sky glow but omits all stars. Such an image can be used as a flat field to accurately compensate for light pollution. The article can be found here.

          March 2016

          Dr. Michael Blaber reapppointed to Journal of Proteins and Proteomics editorial board
          Dr. Michael Blaber, a member of the editorial board of Journal of Proteins and Proteomics (JPP) since 2008 has been reappointed for a new term to the editorial board.

          Feb 2016

          Journal of Proteins and Proteomics adopted by Proteomics Society of India
          The Journal of Proteins and Proteomics (JPP) was established in 2008 as a new journal and with the initial goal of becoming the pre-eminent journal in its field in India. The Proteomics Society of India has decided to adopt JPP and will be responsible for all financial and administrative responsibilities. Dr. Suman Kundu has been the Editor-in-Chief of JPP and is responsible for this remarkable achievement, and will continue on as EIC. Dr. Michael Blaber is a founding editor of the Journal. Congratulations Suman!

          Dr. Xue Xia manuscript accepted in J. Pharm. Sci.
          A manuscript entitled "Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "2nd Generation" Therapeutic Application" and authored by Dr. Xue Xia ("Susie",former graduate student of the Blaber lab) has been accepted for publication in J. Pharm. Sci. Other authors from the Blaber lab include Sachiko Blaber (lab manager and Research Associate), Mason Sutherland (former undergraduate researcher) and Connie Tenorio (current graduate student). The paper describes the development of a form of FGF-1 with enhanced functional half-life due to designed mutations that eliminate reactive buried thiols. Congratulations Susie!.

          Jan 2016

          Trefoil Therapeutics completes pre-IND meeting with FDA
          Trefoil Therapeutics LLC announced completion of a pre-Investigational New Drug (IND) application meeting with the FDA that took place on January 20. The meeting regarded Trefoils lead product candidate TTHX-1114 for the treatment of Bullous Keratopathy and Fuchs Dystrophy. Trefoil CEO Dr. David Eveleth stated "Trefoil has a clear path to the clinic as well as guidance on the FDAs expectations for approval. Trefoil is on schedule to file an IND in 2017 with the first clinical studies planned immediately upon approval of the IND." A pdf of the announcement can be found here.

          Visit to Trefoil Therapeutics laboratory!
          In Jan 2016 Michael and Sachiko Blaber visited the laboratory facilities of Trefoil Therapeutics LLC in San Diego. The facilities are modest in size, but include a remarkably broad range of capabilities - including tissue dissection and culture, protein production, as well as a vivarium. Images from the visit can be found here. Thanks to Dr. David Eveleth, CEO of Trefoil Therapeutics, for hosting this visit.

          Nov 2015

          Drs. Xue Xia and Liam Longo manuscript accepted in a special issue of Protein Science
          A manuscript entitled "Evolution of a Protein Folding Nucleus" co-authored by Drs. Xue Xia and Liam Longo (former graduate students in the Blaber Lab) has been accepted for publication in Protein Science. The report describes how the structure of the critical folding nucleus evolves during gene fusion events that yield complex protein architecture from simpler peptide motifs. This manuscript is likely the first-ever reported study of folding nucleus evolution and will be included in a special issue of Protein Science on Protein Evolution and Design. Congratulations Susie and Liam!

          Encyclopedia of Cell Biology Book Chapter

          An invited book chapter published in the Encylopedia of Cell Biology
          An invited book chapter entitled Folding, Misfolding, Disordered Proteins, and Related Diseases has been published in the Encyclopedia of Cell Biology (Academic Press, Oxford). Drs. Liam Longo and Michael Blaber are authors of this chapter. Congratulations Liam!

          Oct 2015

          Trefoil Therapeutics Awarded NIH R21 Grant for Evaluation of eFGF-1 as Therapy for Ocular Surface Injury
          Trefoil Therapeutics LLC announced that it has received a two-year $500,000 National Eye Institute/National Institute for Neurological Disorders and Stroke grant to demonstrate that engineered forms of FGF-1 (eFGF's) can accelerate healing of corneal epithelial lesions induced by mustard gas. A full description of the announcement can be found here. Dr. Michael Blaber is one of the founders of Trefoil Therapeutics. Congratulations Trefoil!

          Ms. Xue Xia successfully defends Ph.D. thesis
          Ms. Xue Xia (Susie), a graduate student in the Blaber Lab, successfully defended her Ph.D. thesis Engineering Fibroblast Growth Factor-1 (FGF-1) as a Human Therapeutic. Pictures of Susie's defense can be found here. Dr. Xia has accepted a postdoctoral position at Metacrine Inc., a new startup Biotech in San Diego. Congratulations Susie!

          July 2015

          Ncorr 2-D Digital Image Correlation program releases C++ port
          Ncorr, a 2-D digital image correlation program authored by Mr. Justin Blaber, and originally written as MATLAB software, has released an open source C++ port. More innformation can be found at www.ncorr.com.

          Dr. Luiz Juliano manuscript accepted in Biochemical Pharmacology
          A manuscript entitled "Pharmacological Activities and Hydrolysis by Peptidases of [Phospho-Ser6]-Bradykinin (pS6-BK)" by Dr. Luiz Juliano has been accepted in Biochemical Pharmacology. The report describes how post-translational phosphorylation of Ser residues in the vasoactive Bradykinin peptide can substantially alter its processing by proteases. The report opens a new avenue of study in regulation of this important bioactive peptide. Dr. Michael Blaber is a coauthor on this study. Congratulations Luiz!

          Dr. Michael and Ms. Sachiko Blaber attend 20th Wakayama-Florida Sister State Exchange
          Wakayama prefecture in Japan and Florida are Sister States. This July was the 20th Anniversary of establishment of this interaction, and a ceremony to mark the occasion was held in Tallahassee. Dr. Michael and Ms. Sachiko Blaber attended as representatives of FSU. A picture from the reception can be found here.

          Dr. Hyesook Yoon visits Tallahassee from Mayo Clinic, Rochester
          Dr. Hyesook Yoon, a former PhD student and postdoc in the Blaber Lab is currently an Assistant Professor at the Mayo Clinic in Rochester Minnesota. Hyesook is studying myelination of nerves at Mayo, and took time out to visit Tallahassee. Pictures of Hyesook's visit can be found here.

          June 2015

          Dr. Liam Longo visits Tallahassee from Weizmann Institute
          Dr. Liam Longo recently took time out from his postdoctoral studies in protein folding computation at the Weizmann Institute to visit FSU. During this visit we had a mini-symposium (along with Dr. Anant Paravastu, Ms. Xue Xia and Ms. Connite Tenorio - graduate students in the Blaber lab) to discuss ongoing protein folding projects of mutual interest. A picture of Liam from his visit can be found here.

          Apr 2015

          Dr. Liam Longo Awarded Koshland Fellowship
          Dr. Liam Longo, a recent PhD graduate of the Blaber Lab and a current postdoctoral researcher at the Weizmann Institute, has been awarded a prestigious Koshland Fellowship. This fellowship is awarded to the most promising postdoctoral researchers based upon excellence of their PhD research and cross-disciplinary proposal for their postdoctoral research. In Liam's case, his postdoctoral research combines computational and experimental protein folding. Congratulations Liam on this award!

          Drs. Michael Blaber and Jihun Lee Patent Issued
          A patent application entitled "Fibroblast Growth Factor Mutants Having Improved Functional Half-life and Methods of Their Use" by Michael Blaber and Jihun Lee has been issued (8,962,557). This patent is a derivative of patent #8,461,111 and covers position 66 and 83 involving mutations that eliminate buried free cysteines(thus, increasing functional half-life, and creating a novel "2nd-Generation" form of FGF-1 for therapeutic application in healing). Congratulations Jihun!

          Mar 2015

          Ms. Sachiko Blaber manuscript accepted in Wound Repair and Regeneration
          A manuscript authored by Ms. Sachiko Blaber, entitled Accelerated healing in NONcNZO10/LtJ type 2 diabetic mice by FGF-1, has been accepted for publiation in Wound Repair and Regeneration. This report describes a detailed study of dermal wound healing in a diabetic mouse using a splinted excisional surgical procedure. The study also describes how such healing can be accelerated by application of FGF-1, and how a stabilized mutant form of FGF-1 can also accelerate healing without the need for heparin in its formulation. Finally, the study includes a description of a novel mouse jacket design (subsequently licensed to Lomir Biomedical). Drs. Jose Diaz and Michael Blaber in the FSU College of Medicine are coauthors on this report. Congratulations Sachiko! The abstract can be found here.

          Trefoil Therapeutics LLC signs licensing and research support agreements with FSU
          Trefoil Therapeutics LLC, a startup biotech company, has signed an intellectual property licensing agreement and a research support agreement with FSU for eFGF-1 technology. The eFGF-1 technology, developed in the Blaber lab, involves the development of "second generation" engineered forms of fibroblast growth factor-1 for therapeutic application. The press release can be found here.

          Dr. Michael Blaber co-founds Trefoil Therapeutics LLC
          Trefoil Therapeutics LLC, a startup biotech company, has been cofounded by Dr. David Eveleth, Dr. Ralph A. Bradshaw, Dr. Ken A Thomas, and Dr. Michael Blaber. Trefoil Therapeutic's mission is to develop engineered forms of fibroblast growth factor-1 (eFGF-1) for human therapeutic application in corneal dystrophy disease. Subsequent therapeutic development is possible in ischemic diseases (i.e. dermal wound healing, peripheral artery disease, and coronary artery disease). More information can be found here.

          Feb 2015

          Connie Tenorio and Liam Longo win Art in STEM award
          Connie Tenorio and Liam Longo (grad student and former grad student, respectively, in the Blaber Lab) received the first place award in the recent FSU Art in STEM (Science, Technology, Engineering, Mathematics)exhibit. The first prize award was for a rendering of an X-ray diffraction molecular image of the synthetic "Protofoil" protein (a picture can be found here). Congratulations Connie and Liam!

          Manuscript by Dr. Takeshi Hiromoto selected as cover article in Protein Science
          A manuscript entitled Structural basis for acceptor-substrate recognition of UDP-glucose: anthocyanidin 3-O-glucosyltransferase from Clitoria ternatea and authored by Dr. Takeshi Hiromoto of the Japan Atomic Energy Agency (JAEA)(see description below) has been selected as the cover article in Protein Science. Dr. Michael Blaber, a former visiting scientist at JAEA, is a coauthor on this study. Congratulations Dr. Hiromoto!

          Dec 2014

          Manuscript by Dr. Takeshi Hiromoto accepted in Protein Science
          A manuscript entitled Structural basis for acceptor-substrate recognition of UDP-glucose: anthocyanidin 3-O-glucosyltransferase from Clitoria ternatea and authored by Dr. Takeshi Hiromoto of the Japan Atomic Energy Agency (JAEA) has been accepted for publication in Protein Science. This enzyme is involved in the biosynthesis of anthrocyanin pigments - responsible for the color of flowers and fruits. The report details an X-ray structure analysis that elucidates the basis of substrate specificity. Dr. Hiromoto is a researcher in the laboratory of Dr. Ryota Kuroki at the Quantum Beam Science Center, JAEA. Dr. Michael Blaber, a former visiting scientist at JAEA, is a coauthor on this study. Congratulations Dr. Hiromoto!

          Dr. Liam Longo graduation
          Dr. Liam Longo was hooded by Dr. Michael Blaber at the Fall 2014 FSU graduation ceremony. It was a very proud moment for all concerned. A photo of Liam, Sachiko Blaber and Michael Blaber can be found here. Liam now moves to the next phase of his career with a postdoc position at the Weizmann Institute in Israel. Congratulations Liam!

          Nov 2014

          Dr. Liam Longo successfully defends PhD dissertation
          Dr. Liam Longo successfully defended his PhD dissertation "Symmetry and Simplicity in Protein Evolution and Design". Liam will be accepting a Postdoctoral Researcher position in Feb 2015 in the laboratory of Dr. Sarel Fleishman at the Weizmann Institute of Science, studying computational protein design. Congratulations Liam!

          Oct 2014

          Dr. Maria Aparecida Juliano manuscript accepted in BBA - Proteins and Proteomics
          Dr. Maria Aparecida Juliano's report entitled Specificity Studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity has been accepted for publication in Biochimica et Biophysica Acta - Proteins and Proteomics. This report is a detailed analysis of the preferred substrate specificity for human kallikrein-related peptidase 7 - a key protease in the homeostasis of skin. Dr. Michael Blaber was a coauthor on this report. Congratulations Dr. Juliano!

          Mr. Liam Longo manuscript accepted for publication in Protein Science
          Mr. Liam Longo, a graduate student in the Blaber Lab, has had a manuscript entitled A Single Aromatic Core Mutation Converts a Designed "Primitive" Protein from Halophile to Mesophile Folding accepted for publication in Protein Science. Previously, Liam showed that a protein designed using the "prebiotic set" of amino acids exhibited halophile folding properties. In this report, he shows how a single aromatic amino acid mutation can shift folding into the mesophile environment. This work provides experimental evidence for an evolutionary advantage for incorporation of "phase 2" aromatic amino acids into the codon table. Congratulations Liam!

          Technical report published in Amateur Astronomy
          A report entitled Correct Translation, Rotation and Skew Adjustment of the Newtonian Secondary by Combining Laser Collimation with Flat Field Vignetting. and authored by Dr. Michael Blaber has been published in Amateur Astronomy (Issue #84, pages 49-50). This report describes a means by which laser collimation combined with flat field images (showing vignetting) can be utilized in a novel procedure to resolve the rotation/skew ambiguity (and translation) in alignment of the secondary mirror of Newtonian telescopes.A PDF of a the report can be found by clicking here.

          Sep 2014

          Meth. Molec. Biol. Protein Design cover

          Methods in Molecular Biology "Protein Design" book features Symfoil protein on its cover
          A manuscript entitled Symmetric Protein Architecture in Protein Design: Top-Down Symmetric Deconstruction, authored by Mr. Liam Longo and Dr. Michael Blaber, has been published in the Protein Design issue of the Methods in Molecular Biology series. This book features the "Monofoil" protein, a purely-symmetric protein designed in the Blaber Lab, on the cover!

          Ms. Xue Xia manuscript to be included in ?i>Two Decades of Publishing Excellence in Biotechnology?special issue of J. Pharm. Sci.
          Ms. Xue Xia's publication Mutation Choice to Eliminate Buried Free Cysteines in Protein Therapeutics has been selected for inclusion in the upcoming Two Decades of Publishing Excellence in Biotechnology?special issue of Journal of Pharmaceutical Sciences. Congratulations Susie!

          Ms. Xue Xia manuscript accepted for publication in J. Pharm. Sci.
          Ms. Xue Xia, a graduate student in the Blaber Lab, has had a manuscript entitled Mutation Choice to Eliminate Buried Free Cysteines in Protein Therapeutics accepted for publication in Journal of Pharmaceutical Sciences. This is among the first rigorous and systematic studies of mutation design to eliminate buried free Cys residues in proteins, and has important application in design of "2nd-generation" protein therapeutics. Congratulations Susie!

          Aug 2014

          Mr. Liam Longo manuscript accepted for publication in Cell: Structure
          Mr. Liam Longo, a graduate student in the Blaber Lab, has had a manuscript entitled Evolution and design of protein structure by folding nucleus symmetric expansion accepted for publication in Cell: Structure. This report is one of the most important to come out of our lab. It describes a simple, folding nucleus-based, design approach for efficient de novo design of symmetric proteins; and explains how symmetry in protein evolution is advantageous. Congratulations Liam!

          Ms. Connie Tenorio-Zambrano joins Blaber Lab
          Ms. Connie Tenorio-Zambrano who, as an undergraduate did directed independent studies in the lab, has joined as a graduate student from the Biomedical Sciences department of the College of Medicine! Connie is a promising student - having already won a prestigious McKnight Doctoral Fellowship. Welcome Connie!

          Apr 2014

          Dr. Michael Blaber elected to faculty senate
          Dr. Michael Blaber was elected to serve on the FSU faculty senate - the basic legislative body of FSU - for the 2014-2017 academic years.

          Ms. Connie Tenorio-Zambrano wins McKnight Fellowship
          Ms. Connie Tenorio-Zambrano who, as an undergraduate researcher in the Blaber lab was a co-author on a Cell Structure paper and won an NSF undergraduate research award, has recently joined the graduate program in Biomedical Sciences and has won a McKnight Doctoral Fellowship. Congratulations Connie!

          Mar 2014

          Mr. Liam Longo selected for ASBMB Hill Day
          Mr. Liam Longo has been chosen to participate in the American Society for Biochemistry and Molecular Biology Hill Day. Liam will visit Capitol Hill and work with ASBMB to advocate on behalf of scientists. Congratulations Liam!

          Feb 2014

          Mr. Liam Longo Poster takes 2nd Place award
          A poster entitled "Efficient protein design by folding nucleus symmetric expansion" and authored by Mr. Liam Longo (grad student in the Blaber lab) won 2nd place at the recent 4th Annual FSU Life Sciences Symposium. Congratulations Liam!

          Dec 2013

          Mr. Liam Longo manuscript accepted in Frontiers in Extreme Microbiology
          A manuscript entitled Prebiotic Protein Design Supports a Halophile Origin of Foldable Proteins. and authored by Mr. Liam Longo and Dr. Michael Blaber has been accepted in Frontiers Extreme Microbiol. This opinion article argues for the halophile environment as the cradle of proteogenesis (the origin of proteins). Congratulations Liam!

          Mr. Liam Longo manuscript accepted in Journal of Proteins and Proteomics
          A manuscript entitled Biophysical characterization of a thermoalkalophilic esterase from Geobacillus sp. and authored by Mr. Liam Longo has been accepted in J. Prot. Proteomics. Esterases from thermophilic organisms have potential commercial value in the metabolic processing of drugs and antimicrobial agents. In this report Liam characterizes the stability and folding properties of one such enzyme. Dr. Gulsah Sanli-Mohamed is a coauthor on this study. Congratulations Liam!

          Dr. Ryota Kuroki manuscript accepted in IUCr
          A manuscript entitled Structural characteristics of alkaline phosphatase from the moderately halophilic bacteria Halomonas sp.593 and authored by Dr. Ryota Kuroki has been accepted in International Union of Crystallography. This report describes how unique halophilic and mesophilic properties of negative surface charge, and substantial core packing hydrophobicity, respectively, enable alakaline phosphatse from a Halomonas bacteria to function over a uniquely wide range of salt concentrations. Dr. Michael Blaber is a coauthor on this report. Congratulations Ryota!

          Dr. Luciano Puzer manuscript accepted in ACS Medicinal Chemistry Letters
          A manuscript entitled Isomannide-Based Peptidomimetics as Inhibitors for Human Tissue Kallikreins 5 and 7 and authored by Dr. Luciano Puzer has been accepted in ACS Med. Chem. Lett. Dr. Puzer has developed new isomannide-based competitive inhibitors of both KLK5 and KLK7. The results open new prospects on the design and synthesis of highly specific KLK5 and KLK7 inhibitors - with potential human therapeutic utility for inflammatory skin disease. Dr. Michael Blaber is a coauthor on this report. Congratulations Luciano!

          Nov 2013

          Dr. Michael Blaber appointed to J. Pharm. Sci. Editorial Advisory Board
          Dr. Michael Blaber has been appointed to the Editorial Advisory Board of the Journal of Pharmaceutical Sciences for a three year term (Jan 1 2014-Dec 31 2016). J.Pharm.Sci. is published by Wiley Publishers on behalf of the American Pharmacists Association, with the support of the International Pharmaceutical Federation (FIP); it has been in print since 1912.

          Dr. Michael Blaber and Ms. Sachiko Blaber recognized at FSU Innovator's Reception
          Dr. Michael Blaber and Ms. Sachiko Blaber were both recognized at the annual FSU Innovator's Reception. The reception recognizes faculty and staff that have developed intellectual property (filing a patent, having a patent issued, or licensing intellectual property). Dr. Michael Blaber was recognized for licensing IP related to FGF-1 mutants for acclerating wound healing (to E&B Technologies), and Ms. Sachiko Blaber was recognized as a coinventor of a novel mouse jacket (licensed to Lomir Inc.). Images from the reception can be found here.

          Oct 2013

          Dr. Michael Blaber accompanies delegation to China
          Dr. Richard Nowakowski, chair of the department of Biomedical Sciences in the College of Medicine at FSU organized a trip to China. The delegation included Drs. Nowakowski, Branko Stefanovic, Yi Ren, Yi Zhou, Yanchang Wang, Baohui Jia and Haifa Qiao. The delegates gave research presentations at the Chinese Academy of Medical Sciences, Beijing, and Shandong University of Medical Sciences, Jinan. The purpose of the trip was to explore potential collaborative research projects between FSU and these institutions. Images from the trip can be found here.

          Blaber Lab retreat to St. George Island
          This October we had a much-needed 3-day lab retreat at St. George Island. Images can be found here.

          Sep 2013

          Mr. Liam Longo manuscript accepted for publication in Cell: Structure
          Mr. Liam Longo, a graduate student in the Blaber Lab, has had a manuscript entitled Alternative Folding Nuclei Definitions Facilitate the Evolution of a Symmetric Protein Fold from a Smaller Peptide Motif accepted for publication in Cell: Structure. Using a designed b-trefoil protein, this report shows that purely symmetric 1?structure enables utilization of alternative definitions of the critical folding nucleus in response to gross structural rearrangement. Thus, major replication errors producing 1?structure symmetry can conserve foldability. The results provide an explanation for the prevalence of symmetric protein folds, and highlight a critical role for 1?structure symmetry in protein evolution. Congratulations Liam!

          Lomir Biomedical Inc. markets "Butterfly Mouse Harness"
          A novel mouse jacket designed and patented by Dr. Michael Blaber and Ms. Sachiko blaber of the Blaber lab, has been succesfully licensed by Lomir Biomedical Inc. Lomir is now actively marketing this product (for details see here). Congratulations Sachiko!

          July 2013

          Dr. Michael Blaber receives "Outstanding Senior Faculty Researcher" award
          At the recent College of Medicine faculty awards ceremony, Dr. Michael Blaber was awarded the "Outstanding Senior Faculty Researcher" award for 2012-2013. This achievement is a testament to the hard work and accomplishments of the members of the lab, and the outstanding environment within the department of Biomedical Sciences; thank you!

          Mr. Justin Blaber develops 2D digital image correlation program Ncorr
          Mr. Justin Blaber, a graduate student in mechanical engineering at Georgia Tech, has developed a 2D digital image correlation MATLAB program along with an associated web site. The program, Ncorr, has broad applicability and extensibility in 2D image correlation, and was developed to help understand structural deformations in ceramic materials. The web site can be found here. Congratulations Justin!

          Blaber lab licenses novel mouse jacket to Lomir Biomedical
          A licensing agreement has been concluded between Lomir Biomedical and FSU for a novel mouse jacket invented by Dr. Michael Blaber and Ms. Sachiko Blaber. Lomir is a global leader in the design and manufacter of biomedical equipment, with offices in the US, Canada and the UK. In pursuing animal studies of wound healing the Blaber team designed and submitted a US patent for a novel mouse jacket that provides essential protection of the surgical field while being highly resistant to removal, and at the same time providing a substantial advantage in ease of manufacture. A movie of a the jacket can be found by clicking here.

          Mr. Liam Longo manuscript accepted for publication in Methods in Molecular Biology
          A manuscript entitled Symmetric Protein Architecture in Protein Design: Top-Down Symmetric Deconstruction, authored by Mr. Liam Longo and Dr. Michael Blaber, has been accepted for publication in a Protein Design issue of the Methods in Molecular Biology series. This manuscript is a practial laboratory guide to the novel Top-Down Symmetric Deconstruction strategy in protein design. Congratulations Liam!

          June 2013

          Mr. Liam Longo manuscript selected by Faculty of 1000
          Mr. Liam Longo's manuscript entitled Simplified Protein Design Biased for Pre-Biotic Amino Acids Yields a Foldable, Halophilic Protein has been selected by the Faculty of 1000 (F1000), which places the work in the top 2% of published articles in biology and medicine. Information can be found here. Congratulations Liam!

          May 2013

          Ms. Helen Phipps manuscript accepted for publication in Brain Injury
          Ms. Helen Phipps, former grad student in the Blaber and VanLandingham labs, has had a manuscript entitled Kallikrein-related Peptidase 6: A Biomarker for Traumatic Brain Injury in Rat accepted for publication in Brain Injury. Dr. Michael Blaber and Ms. Sachiko Blaber are coauthors on this study. Congratulations Helen!

          Ms. Helen Phipps successfully defends Ph.D. thesis
          Ms. Helen Phipps, a graduate student co-mentored in the laboratories of Drs. Jacob VanLandingham and Michael Blaber successfully defended her Ph.D. thesis entitled Impact of Traumatic Brain Injury on Kallikrein 6. Congratulations Helen!

          Drs. Michael Blaber and Jihun Lee Patent Issued
          A patent application entitled "Fibroblast Growth Factor Mutants Having Improved Functional Half-life and Methods of Their Use" by Michael Blaber and Jihun Lee has been issued (Appl. #12/783,005). This patent covers position Ala66Cys mutants in FGF-1, whereby an internal disulfide bond with Cys83 is formed. This disulfide stabilizes the protein and reduces the number of free buried thiols (thus, increasing functional half-life, and creating a novel "2nd-Generation" form of FGF-1 for therapeutic application in healing). Congratulations Jihun!

          Ms. Connie Tenorio-Zambrano receives NSF summer research fellowship
          Ms. Connie Tenorio-Zambrano, an undergraduate researcher in the Blaber lab, has been awarded a 2013 NSF summer research fellowship (awarded through the Florida A&M University National Science Foundation Research Experience as an Undergraduate SUMMER-13 Program). Connie will be working on a project involving protein structure and folding relationships in the Blaber lab this summer. Congratulations Connie!

          Ms. Hyesook Yoon manuscript accepted for publication in J. Neurochem.
          Ms. Hyesook Yoon, former grad student and postdoc in the Blaber lab has had a manuscript entitled Kallikrein 6 Signals through PAR1 and PAR2 to Promote Neuron Injury and Exacerbate Glutamate Neurotoxicity accepted for publication in the Journal of Neurochemistry. Dr. Michael Blaber and Ms. Sachiko Blaber are coauthors on this important study. Congratulations Hyesook!

          April 2013

          Mr. Joseph Babcock receives summer research fellowship
          Mr. Joseph Babcock, a first year medical student in the FSU College of Medicine, has been awarded a 2013 Summer Research Fellowship. Joseph will be studying the acceleration of healing in response to engineered forms of fibroblast growth factor-1 in the Blaber lab. Congratulations Joseph!

          Mr. Liam Longo wins 2013 Kasha Award
          The Kasha Award is given each year for the most outstanding publication by a Molecular Biophysics graduate student. Liam Longo won this year's award for his publication entitled "Simplified Protein Design Biased for Pre-Biotic Amino Acids Yields a Foldable, Halophilic Protein" published in Proc. Natl. Acad. Sci. USA. Congratulations Liam!

          Provisional Patent Application Filed for a Novel Mouse Jacket Design
          In order to pursue wound healing studies we needed to come up with a better mouse jacket (one that could not be removed easily). We succeeded in developing such a jacket from a specially-shaped piece of double-sided velcro. It worked so well that FSU submitted a patent "Improved Mouse Jacket". The inventors are Michael Blaber and Sachiko Blaber. Congratulations Sachiko!

          March 2013

          Dr. Luciano Puzer manuscript accepted in Biochem. Biophys. Res. Comm.
          A manuscript entitled "Human Tissue Kallikreins 3 and 5 can Act as Plasminogen Activator Releasing Active Plasmin" and authored by Dr. Luciano Puzer has been accepted for publication in Biochemical and Biophysical Research Communications. This manuscript describes how these two kallikreins are capable of activating plasminogen, and identifies an important functional intersection between the KLK family of proteases and the thrombostasis system. Dr. Michael Blaber is a coauthor on this study. Congratulations Luciano!

          Feb 2013

          Mr. Liam Longo manuscript receives Protein Society "Best Paper" Award
          A recent manuscript published by Mr. Liam Longo (graduate student in Blaber lab) in Protein Science entitled "Experimental Support for the Foldability-Function Tradeoff Hypothesis: Segregation of the Folding Nucleus and Functional Regions in FGF-1" is one of two reports in the journal to be selected for "Best Paper" award of 2012, and Liam will give an invited oral presentation at the Annual Protein Society Symposium in Boston in July. Congratulations Liam!

          Jan 2013

          KLK6 Review published
          Chapter 612 in the 3rd Edition of Handbook of Proteolytic Enzymes, entitled Kallikrein-related Peptidase 6 was published this month.

          Dec 2012

          Dr. Michael Blaber attends IISC meeting in India
          The International Interdisciplinary Science Conference 2012 on Protein Folding and Disease was held in Delhi, Dec 8-10. Dr. Michael Blaber attended and gave a talk on "Top-Down Symmetric Deconstruction". Images and thoughts from the trip can be found here.

          Manuscript by Mr. Liam Longo accepted in PNAS
          A manuscript entitled "Simplified Protein Design Biased for Pre-biotic Amino Acids Yields a Foldable, Halophilic Protein" and authored by Mr. Liam Longo (graduate student in the Blaber Lab) has been accepted for publication in Proceedings of the National Academy of Sciences. This report tests the hypothesis that the pre-biotic set of amino acids comprises a foldable set, and in the process, identifies a potential halophilic property intrinsic to the pre-biotic amino acids. Congratulations Liam!

          Blaber lab awarded CRC Planning Grant
          A planning grant entitled "Development of third-generation?FGF-1 mutants for therapeutic application" has been awarded to the Blaber lab from the FSU Council of Research and Creativity.

          Commentary by Mr. Liam Longo and Dr. Michael Blaber accepted in Journal of Proteins and Proteomics
          A manuscript entitled "Protein Design -- A Vast Unexploited Resource" and authored by Mr. Liam Longo (graduate student in the Blaber Lab) and Michael Blaber has been accepted for publication in Journal of Proteins and Proteomics. Congratulations Liam!

          Oct 2012

          Mr. Liam Longo manuscript accepted in Protein Science
          A manuscript entitled "Experimental Support for the Foldability-Function Tradeoff Hypothesis: Segregation of the Folding Nucleus and Functional Regions in FGF-1" and authored by Mr. Liam Longo (graduate student in the Blaber Lab) has been accepted for publication in Protein Science. This manuscript describes a phi-value analysis of FGF-1 and shows that turns critical for folding are segregated from functional domains. The study has important and diverse implications for protein evolution. Congratulations Liam!

          Sep 2012

          Ms. Xue Xia manuscript accepted in PLOS ONE
          A manuscript entitled "Pharmacokinetic Properties of 2nd-generation Fibroblast Growth factor-1 Mutants for Therapeutic Application" and authored by Ms. Xue Xia(graduate student in the Blaber Lab) has been accepted for publication in PLOS ONE. This manuscript studies the pharmacokinetic profile of mutant forms of FGF-1 and shows how both distribution and elimination kinetics can be controlled by specific mutation of the protein. Congratulations Xue!

          Dr. Hyesook Yoon manuscript accepted in Biological Chemistry
          A manuscript entitled "Activation Profiles of Human Kallikrein-related Peptidases by Matrix Metalloproteinases " and authored by Dr. Hyesook Yoon (former grad student and postdoc in the lab) has been accepted for publication in Biological Chemistry. This manuscript demonstrates the ability of members of the matrix metalloproteinase family to activate specific kallikrein-related peptidases, and thus identifies potentially important regulatory interactions between these two major protease families. Congratulations Hyesook!

          Aug 2012

          Dr. Luciano Puzer manuscript accepted in Bioorg. Med. Chem. Lett.
          A manuscript entitled "Pseudo-peptides derived from isomannide as new class of inhibitors for human kallikrein 7" and authored by Dr. Luciano Puzer has been accepted for publication in Bioorganic Medicinal Chemistry Letters. This manuscript describes a novel class of pseudo-peptide small molecule protease inhibitors derived from isomannide. Dr. Michael Blaber and Ms. Sachiko Blaber were coauthors on this study. Congratulations Luciano!

          July 2012

          THCA synthase JMB cover

          Dr. Ryota Kuroki manuscript accepted in J. Mol. Biol.
          A manuscript entitled "Structure and Function of d1-Tetrahydrocannabinolic Acid (THCA) Synthase, the Enzyme Controlling the Psychoactivity of Cannabis sativa" and authored by Dr. Ryota Kuroki has been accepted for publication in Journal of Molecular Biology. This manuscript describes an X-ray crystal structure and mutational study of TCHA Synthase and elucidates the chemical mechanism of action. Dr. Michael Blaber was a coauthor on this study. A figure from this report was also selected for the Journal Dec 2012 cover; congratulations Ryota!

          June 2012

          Dr. Michael Blaber manuscript accepted in Arch. Biochem. Biophys.
          An invited review entitled "Protein design at the interface of the pre-biotic and biotic worlds" and authored by Dr. Michael Blaber and Mr. Liam Longo (grad student in the lab) has been accepted for publication in Archives of Biochemistry and Biophysics. In this review we analyze the available information for plausible pre-biotic amino acids and conclude that they likely comprise a "foldable set" within a halophile/acidophile environment. Thus, "proteogenesis" is a likely principle player in biogenesis.

          Dr. Michael Blaber manuscript accepted in Cell. Molec. Life Sci.
          An invited review entitled "Emergence of Symmetric Protein Architecture from a Simple Peptide Motif: Evolutionary Models" and authored by Dr. Michael Blaber, Dr. Jihun Lee (former postdoc in the lab) and Mr. Liam Longo (grad student in the lab) has been accepted for publication in Cellular and Molecular Life Sciences. Recent experimental studies in "top-down" protein design largely support a conserved architecture?evolutionary model, suggesting that complex protein architecture was an early evolutionary achievement involving oligomerization of smaller polypeptides.

          Dr. Gulsah Sanli joins Blaber Lab as Visiting Scientist
          Dr. Gulsah Sanli, an Assistant Professor of Chemistry at Izmir Institute of Technology, Turkey, is a Visiting Scientist for the summer semester. Dr. Sanli is studying the structural biology of thermophilic enzymes from hot springs in Turkey. Dr. Sanli is a former Ph.D. student from the Blaber Lab (1998-2002).

          May 2012

          Dr. Michael Blaber manuscript accepted in Curr. Opin. Struct. Biol.
          An invited review entitled "Designing Proteins from Simple Motifs: Opportunities in Top-Down Symmetric Deconstruction" and authored by Drs. Michael Blaber and Jihun Lee has been accepted for publication in Current Opinion in Structural Biology. This manuscript proposes that disparate recent efforts in "top-down" protein design can be unified in a common design principle - one that will accelerate efficient identification of simple structural building blocks for de novo protein design.

          April 2012

          Two U.S. Patents issued to Drs. Blaber and Dubey
          Two U.S. patents (8,153,770 and 8,153,771) were issued as divisionals to patent 7,659,379, "Mutants of Human Fibroblast Growth Factor Having Increased Stability and/or Mitogenic Potency", with inventors Dr. Michael Blaber and Vikash Kumar Dubey. Congratulations Vikash!

          March 2012

          Two manuscripts published by Dr. Ryota Kuroki
          Two reports,"Substrate recognition mechanism of a glycosyltrehalose trehalohydrolase (GTHase) from sulfolobus solfataricus KM1", and "A structural mechanism for dimeric to tetrameric oligomer conversion in halomonas sp. nucleoside diphosphate kinase", by Dr. Ryota Kuroki were both published in Protein Science. Dr. Blaber was a co-author on these studies. Congratulations Dr. Kuroki!

          Jan 2012

          Blaber Lab awarded FSU GAP grant
          The Blaber Lab has been awarded a $50,000 FSU "GAP" grant to undertake translational research on "second generation" Fibroblast growth factor-1 (FGF-1) proteins. This grant will permit wound healing studies to be performed for the purpose of identifying the therapeutic advantage of designed mutant forms of FGF-1. This study is a collaboration with Dr. Joseph Schlenoff in the department of Chemistry at FSU, and will include tests of a novel bandage material intended to provide controlled loading and dosing of FGF-1.

          Dec 2011

          Ms. Sara Jackson graduates with M.S. degree
          Ms. Sara Jackson, a graduate student in the Blaber Lab, graduated in the Fall 2011 semester with an M.S. degree in biomedical sciences. Congratulations Sara!

          Nov 2011

          Middaugh/Blaber lab's study on "Second Generation" FGF-1 accepted for publication
          The laboratories of Dr. Russ Middaugh (U. Kansas) and Dr. Michael Blaber have been collaborating on a study to utilize mutations in FGF-1 to achieve formulation goals for therapeutic application. In this report a series of "second-generation" mutants of FGF-1 was characterized using "empirical phase diagrams", and several mutants do not require heparin in their formulation as a stabilizing agent. This work was coauthored by Dr. Jihun Lee (Blaber Lab), Mohammad Alsenaidy (Middaugh Lab) and Dr. Tingting Wang (Middaugh Lab), and has been accepted for publication by Protein Science. Congratulations to all involved!

          ChemWiki on track to surpase MIT's OpenCourseWare
          Dr. Michael Blaber is a participant in the ChemWiki project to develop the next generation of open-access textbooks to improve STEM (science, technology, engineering and mathmatics) education. The latest update indicates ChemWiki will surpase MIT's OpenCourseWare traffic. ChemWiki's web site is located here.

          Oct 2011

          Dr. Luciano Puzer manuscript published in Bioorg. Med. Chem. Lett.
          Dr. Luciano Puzer's report entitled "Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7" has been published in Bioorganic and Medicinal Chemistry Letters. K5 and K7 inhibitors may have therapeutic application in important disease conditions of the skin. Michael Blaber and Sachiko Blaber are co-authors on this report. Dr. Puzer is a former visiting scientist in the Blaber Lab and is a professor in the Universidade Federal do ABC in Brazil. Congratulations Dr. Puzer!

          Sep 2011

          Blaber Lab research featured in FSUMED magazine
          Dr Jihun Lee's cover article in Journal of Molecular Biology (Vol 407, issue 5, 2011) was featured in the latest issue of FSUMED magazine (page 3). Congratulations Jihun! Link to a PDF of this issue can be found here.

          Aug 2011

          Blaber Lab manuscript featured on Global Medical Discovery site
          A recent Blaber Lab article by Dr. Jihun Lee entitled "A polypeptide "building block" for the beta-trefoil fold identified by "top-down symmetric deconstruction" and published in the Journal of Molecular Biology has been featured as a key scientific article on the Global Medical Discovery web site. Details here.

          July 2011

          Michael Blaber manuscript published in Amaeteur Astronomy
          An article entitled "As the Worm Turns: One Man's Descent into Periodic Error" by Michael Blaber has been published in Vol 71 of Amateur Astronomy. The article describes the effects of worm gear misalignment on the periodic error of a telescope mount, and a method to correct such misalignment. PDF file of the article can be found here.

          Blaber Lab visits the local roller derby!
          The lab took a break and watch a local roller derby match between the Jailbreak Bettys and the Molly Rogers. Pictures of this cultural event can be found here

          June 2011

          Ms. Sara Jackson recieves fellowship award
          Ms. Sara Jackson is the recipient of a Bryan Robinson Endowment fellowship award for research in the neurosciences. Sara is currently working to identify the CNS-specific inhibitor of human kallikrein-related peptidase 6 (a protease associated with inflammatory demyelination). Congratulations Sara!

          Dr. Luiz Juliano manuscript accepted in Biochimie
          Dr. Luiz Juliano's report entitled Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates and produced in collaboration with the Blaber lab, has been accepted for publication in Biochimie. This report describes how the human KLK13 protease is activated by sodium citrate and glycosaminoglycans present in certain human tissues; furthermore, histatin 3, myelin basic protein and testis-specific proteins are likely substrates of KLK13. Congratulations Dr. Juliano!

          May 2011

          Dr. Jihun Lee receives award
          Dr. Jihun Lee has received the Outstanding Achievement as a Postdoctoral Scholar Award from the department of Biomedical Sciences at FSU. This award is in recognition of her recently-published work in Proceedings of the National Academy of Sciences and Journal of Molecular Biology in addition to two patent applications (all in the field of protein design). Dr. Lee is currently a postdoctoral researcher at NIH. Congratulations Jihun!

          Drs. Peter Angel and Jochen Hess manuscript accepted in Journal of Investigative Dermatology
          Drs. Peter Angel and Jochen Hess, in collaboration with the Blaber lab, report that KLK6, in combination with PAR1 activation, can induce melanoma cell invasion. Thus, specific inhibition of KLK6 may represent a new therapeutic approach in the treatment of this agressive type of cancer. Congratulations Drs. Angel and Hess!

          Apr 2011

          Ms. Xue Xia joins Blaber Lab
          Ms. Xue Xia ("Susie") a graduate student in the department of Biomedical Sciences in the FSU College of Medicine has joined the Blaber Lab. Susie will be working on the FGF project. Welcome Susie!

          Blaber Lab publication upgraded to "Must Read" by Faculty of 1000
          Dr. Jihun Lee's recent PNAS paper entitled "Experimental support for the evolution of symmetric protein architecture from a simple peptide motif" has been upgraded by Faculty of 1000 (a post-publication peer-review organization) to "Must Read" status. The review can be found here.

          Mar 2011

          Earthquake during spring JAEA visit
          This year's visit to the Japan Atomic Energy Agency in Tokai Village, Japan, by Dr. Michael Blaber unfortunately coincided with the largest earthquake in Japanese history. Pictures and a personal account can be found here.

          Symfoil synthetic protein

          J. Mol. Biol. selects cover art from Blaber lab publication
          The April 15th issue of the Journal of Molecular Biology will feature on its cover an image from the Blaber lab report entitled "A polypeptide "building block" for the b-trefoil fold identified by "top-down symmetric deconstruction"". The image shows a "ribbon diagram" from the X-ray stucture of a synthetic protein designed in the Blaber laboratory and overlaid with a symbol from the middle ages known as a "trefoil". This symbol is used in European architecture and the similarity with the atomic details of the synthetic protein are striking. Congratulations to the author of this report, Dr. Jihun Lee!

          Feb 2011

          Another Blaber lab paper selected by Faculty of 1000
          Dr. Jihun Lee's recent JMB paper entitled "A polypeptide "building block" for the b-trefoil fold identified by "top-down symmetric deconstruction"" has been selected by the Faculty of 1000 (F1000), which places the work in the top 2% of published articles in biology and medicine. Information can be found here. Congratulations Jihun!

          Blaber lab PNAS paper selected by Faculty of 1000
          Dr. Jihun Lee's recent PNAS paper entitled "Experimental support for the evolution of symmetric protein architecture from a simple peptide motif" has been selected by the Faculty of 1000 (F1000), which places the work in the top 2% of published articles in biology and medicine. Information can be found here. Congratulations Jihun!

          Dr. Jihun Lee manuscript accepted for publication in JMB
          A manuscript entitled "A Polypeptide "Building Block" for the b-Trefoil Fold Identified by "Top-Down Symmetric Deconstruction"" by Dr. Jihun Lee (former grad student and postdoc in the lab) has been accepted for publication in Journal of Molecular Biology. This report describes the details of a novel methodology to design peptide "building blocks" for symmetric protein architecture. Congratulations Jihun on another excellent paper!

          Jan 2011

          Blaber lab awarded a Florida Department of Health grant
          The Blaber lab was awarded a Florida Department of Health Technology Transfer Feasibility Grant (1KF03) "Development of "second-generation" fibroblast growth factor-1 for pro-angiogenic therapy". The grant is to support pre-clinical pharmacokinetic studies of mutant forms of human fibroblast growth factor (FGF-1). The goal is to identifying "second-generation" forms of FGF-1 for application in novel "pro-angiogenic" therapy in patients with ischemic disease that cannot be effectively treated by current therapies.

          1st Annual FSU Life Sciences Symposium
          The 1st Annual FSU Life Sciences Symposium was held Jan 7-8 in the College of Medicine at FSU. This meeting was designed to highlight the diverse biomedical research on-going at FSU, and included attendees and speakers from the departments of Chemistry & Biochemistry, Biological Science, Psychology, Physics, Mathematics, Chemical and Biomedical Engineering, the National High Magnetic Field Laboratory, Program in Neuroscience, and Institute of Molecular Biophysics. The organizing commitee was chaired by Dr. Michael Blaber. The symposium proceedings can be found here. Pictures from the meeting can be found here.

          Dec 2010

          Dr. Jihun Lee manuscript published
          A manuscript written by Dr. Jihun Lee, entitled Increased Functional Half-life of Fibroblast Growth Factor-1 by Recovering a Vestigial Disulfide Bond has been published in J. Proteins Proteomics. This report describes how a novel disulfide bond mutant of FGF-1 increases the in vitro functional half-life of the protein by 14-fold. This mutant design approach may be applicable to "second-generation" forms of different members of the fibroblast growth factor family. Congratulations Jihun!

          Dr. Hyesook Yoon accepts Mayo Clinic position
          Dr. Hyesook Yoon (grad student/postdoc Blaber Lab) accepted a postdoctoral position at the Mayo Clinic, Rochester. As an alumni of the Blaber Lab, Hyesook published 3 papers as a first author, and 3 as coauthor (and with another manuscript in preparation). Her study of the activation profiles of the human pro-KLKs contribued to the 2009 E.K.Frey/E. Werle gold medal awarded to the Blaber laboratory for kallikrein research. We wish her the best of luck in this next phase of her career; she will be missed terribly.

          Nov 2010

          Dr. Jihun Lee manuscript accepted for publication in PNAS
          A manuscript entitled "Experimental support for the evolution of symmetric protein architecture from a simple peptide motif" by Dr. Jihun Lee (former grad student and postdoc in the lab) has been accepted for publication in Proceedings of the National Academy of Sciences. This report provides experimental support for one of two competing hypotheses regarding molecular details of the evolution of the b-trefoil protein fold, from a simple peptide motif, via gene duplication and fusion processes. There are several significant implications of this report to protein evolution and design. Congratulations Jihun on this excellent paper!

          Oct 2010

          Dr. Jihun Lee accepts NIH position
          Dr. Jihun Lee (grad student/postdoc Blaber Lab) accepted a postdoctoral position in the laboratory of Dr. Peter Sun, Chief, Structural Immunology Section, Nationl Institute of Alergy and Infectious Diseases, NIH. As an alumni of the Blaber Lab, Jihun published 5 papers as a first author, and 7 as coauthor (and with a couple more currently being written). She solved 33 X-ray crystal structures of mutant FGF-1 proteins, as well as solved the structure of rabbit FGF-1. She also has two patent applications relating to protein therapeutics and protein design. We wish her the best of luck in this next step of her promising career; she will be sorely missed.

          Sep 2010

          Blaber & Brych Patent Issued
          U.S. Patent 7,780,682, "Engineered Human Acidic Fibroblast Growth Factors and Associated Methods", by Blaber, M. and Brych, S. was issued on Sep 7, 2010. The patent covers a mutant form of FGF-1 that is highly-stable, lacks heparin-binding affinity, and is ~100x more potent than the wild-type FGF-1 protein in the absence of added heparin. Congratulations to co-inventor Dr. Stephen Brych.

          Aug 2010

          Fourth Blaber & Dubey patent issued
          U.S. Patent 7,776,825, Mutant Polypeptides of Fibroblast Growth Factor 1 was issued Aug 17, 2010 (inventors Blaber, M. and Dubey, V.K.). This patent covers additional mutations at positions 12 and 134 of FGF-1 that substantially increase the thermostability as well as potency in the absence of added heparin. Such mutants are candidates for "second generation" forms of FGF-1 for pro-angiogenic therapy.

          Dr. Michael Blaber joins Editorial Board of Archives of Biochemistry and Biophysics
          Dr. Michael Blaber was recently invited to join the Editorial Board of Archives of Biochemistry and Biophysics a notable journal in biophysics and biochemistry published by Elsevier.

          May 2010

          Blaber Lab retreat to watch Atlantis launch
          This year's lab retreat was in Titusville, Fl to watch the last launch of the Shuttle Atlantis, and one of the last Shuttle launches before the U.S. manned flight program using the Shuttle is ended. We had an excellent view of the launch, and were about as close as you can get. The noise was unbelievable. Images can be found here.

          Ms. Cristina Russo successfully defends Ph.D. thesis
          Ms. Cristina Russo, a graduate student co-mentored in the laboratories of Drs. Marcia Fenley and Michael Blaber successfully defended her Ph.D. thesis entitled Salt-dependence of protein-DNA binding: insights into protein electrostatics and redesign . Congratulations Cristina!

          Dr. Michael Blaber joins Editorial Board of Research Reports in Biology
          Dr. Michael Blaber was recently appointed to the Honorary Editorial Board of Research Reports in Biology an open access online journal published by Dove Press.

          Apr 2010

          Dr. Michael Blaber joins the Program in Neuroscience at FSU
          The FSU Program in Neuroscience is an independent research and graduate training program and includes faculty from the departments of Biological Science, Biomedical Science, Mathematics, and Psychology. Its objective is to promote interdisciplinary basic research into neural processes, including the biological mechanisms underlying behavior, and to provide advanced graduate training leading to the Ph.D. degree in Neuroscience.

          Third Blaber & Dubey patent issued
          U.S. Patent 7,696,171, Mutant Polypeptides of Fibroblast Growth Factor 1 was issued Apr 13, 2010 (inventors Blaber, M. and Dubey, V.K.). This patent covers additional mutations at positions 12 and 134 of FGF-1 that substantially increase the thermostability as well as potency in the absence of added heparin. Such mutants are candidates for "second generation" forms of FGF-1 for pro-angiogenic therapy.

          Mar 2010

          Dr. Luiz Juliano manuscript accepted for publication
          A manuscript entitled "Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans", written by Dr. Luiz Juliano, has been accepted for publication in Archives of Biochemistry and Biophysics. Dr. Juliano is a long-standing collaborator and Sachiko Blaber and Dr. Michael Blaber are co-authors of this study. Congratulations to Dr. Juliano!

          Feb 2010

          Second Blaber & Dubey patent issued
          U.S. Patent 7,659,379, Mutants of Human Fibroblast Growth Factor Having Increased Stability and/or Mitogenic Potency was issued Feb 9 2010 (inventors Blaber, M. and Dubey, V.K.). This patent covers additional mutations at positions 12 and 134 of FGF-1 that substantially increase the thermostability as well as potency in the absence of added heparin. Such mutants are candidates for "second generation" forms of FGF-1 for pro-angiogenic therapy.

          Mr. Liam Longo and Ms. Sara Jackson join Blaber Lab
          Graduate students Mr. Liam Longo (Molecular Biophysics program) and Ms. Sara Jackson (Biomedical Sciences program) have joined the Blaber Lab. Liam's graduate studies will focus upon protein folding, and Sara's graduate studies will focus upon Kallikrein-related peptidase enzymology. It's great to have two new graduate students in the lab, and a hearty welcome to both of them!

          Jan 2010

          Inaugural issue of Journal of Proteins and Proteomics
          The first issue of the JPP has been published, with an editorial on the need for protein chemists contributed by Dr. Michael Blaber. A link to the issue can be found here.

          Dec 2009

          Dr. Hyesook Yoon joins Blaber Lab
          Dr. Hyesook Yoon has started a postdoctoral research position in the Blaber Lab, focusing upon the study of Kallikrein-related peptidases. Dr. Yoon was a former graduate student of the lab (Ph.D. in Chemistry, 2008), and it is great to have her back in the lab once again.

          Nov 2009

          Dr. Michael Blaber manuscript accepted for publication
          A review article on the interactions between Kallikrein-related peptidases and thrombostasis proteases, entitled "Functional intersection of the Kallikrein-related peptidases (KLKs) and thrombostasis axis" has been accepted for publication in Biological Chemistry.

          Oct 2009

          Dr. Jihun Lee/Sachiko Blaber manuscript accepted for publication
          A manuscript jointly-authored by Dr. Jihun Lee and Sachiko Blaber, entitled X-ray Structure and Biophysical Properties of Rabbit Fibroblast Growth Factor-1 has been accepted for publication in Acta Cryst. F. This report describes the cDNA sequence, thermostability, receptor-binding affinity, mitogenic activity and X-ray crystal structure of rabbit FGF-1. Congratulations Jihun and Sachiko!

          Sep 2009

          Blaber & Dubey patent issued
          U.S. Patent 7,595,296, Mutant Polypeptides of Fibroblast Growth Factor 1 was issued Sep 30 2009 (inventors Blaber, M. and Dubey, V.K.). This patent covers mutations at positions 12 and 134 of FGF-1 that substantially increase the thermostability as well as potency in the absence of added heparin. Such mutants are candidates for "second generation" forms of FGF-1 for pro-angiogenic therapy.

          Josh Kogot manuscript accepted for publication
          Joshua Kogot, a graduate student in the laboratory of Dr. Geoffrey Strouse, has had his manuscript entitled "Analysis of the Dynamics of Assembly and Structural Impact for a Histidine Tagged FGF-1 ?1.5 nm Au Nanoparticle Bioconjugate" accepted for publication in Bioconjugate Chemistry. This study describes the structural changes to a mutant form on FGF-1 upon attachment to gold nanoparticles, and contributes to our understanding of protein conjugates in nanotechnology. Drs. Jihun Lee and Michael Blaber were coauthors in this study. Congratulations Josh!

          Dr. Michael Blaber receives Frey-Werle Gold Medal
          Dr. Michael Blaber was awarded the E.K. Frey-E. Werle Commemorative Gold Medal at the 3rd International Symposium on Kallikreins and Kallikrein-related Peptidases. This medal was awarded for Fundamental Contributions to the Structural Biology and Enzymology of the Human Kallikrein-related Peptidases. Pictures of the award ceremony can be found here.

          Dr. Akshaya Meher manuscript accepted for publication
          Dr. Akshaya Meher's manuscript "Engineering an Improved Crystal Contact across a Solvent-Mediated Interface of Human Fibroblast Growth Factor-1" has been accepted for publication in Acta Cryst. F. In this report Dr. Meher demonstrates how mutations at a protein crystal contact interface, that substitute direct molecular contacts for a solvent-mediated interface, can improve the crystal growth. Congratulations Akshaya!

          Blaber Lab receives high ranking in Structural Biology
          The Structural Biology Rankings web site (http://www.molecularstructure.org/) ranks the impact of investigators in structural biology based opon a combination of total citation data, PDB download statistics of deposited structures, and other factors. In this ranking, the Blaber Lab is identified as being among the top 40 structural biology groups in the world (currently ranked 36th). Thanks go to the hardworking folks, past and present, within the lab.

          Aug 2009

          Another Dr. Jihun Lee manuscript accepted for publication!
          Dr. Jihun Lee's manuscript "The Interaction between Thermodynamic Stability and Buried Free Cysteines in Regulating the Functional Half-life of Fibroblast Growth Factor-1" has been accepted for publication in Journal of Molecular Biology. In this report Dr. Lee shows that buried thiols and thermodynamic stability interact to provide effective regulation of protein functional half-life. This study identifies a protein engineering strategy to achieve a targeted functional half-life in mutant proteins. Congratulations Jihun!

          Dr. Jihun Lee manuscript accepted for publication
          Dr. Jihun Lee's manuscript, "Structural Basis of the Conserved Cysteine in the Fibroblast Growth Factor Family: Evidence for a Vestigial Half-cystine" has been accepted for publication in Journal of Molecular Biology. In this report Dr. Lee shows that the conserved cysteine residue in the FGF family of proteins can be considered a vestigial half-cystine. In members with a cystine, the contribution of this residue is primarily to stabilize the protein; whereas, in members with a free cysteine, the contribution is to an irreversible unfolding pathway (due to thiol reactivity) and regulation of functional half-life. Congratulations Jihun!

          July 2009

          Dr. Michael Blaber appointed as Invited Research Fellow at JAEA
          Dr. Michael Blaber has been appointed as an Invited Research Fellow to the Japan Atomic Energy Agency (JAEA) for 2009-2010. This appointment will involve research into structural biology associated with neutron diffraction at JAEA, Tokai, Japan. Blaber will interact with researchers in the laboratory of Dr. Ryota Kuroki, Quantum Beam Science Directorate. Pictures from the July 2009 visit are here .

          May 2009

          Blaber Lab Retreat at Amelia Island!
          The lab had a much-deserved three day retreat at Amelia Island on the Atlantic coast of North Florida. Pictures are here .

          Mar 2009

          Blaber Lab research highlighted in FSU "Research in Review"
          Our protein engineering of the FGF-1 protein, and its potential application in a novel treatment for heart disease, has been highlighted in the winter 2009 edition of FSU's Research in Review. To download a copy of this article click here. Thanks to the hard-working folks in the lab, especially Dr. Jihun Lee, for this accomplishment.

          Feb 2009

          Blaber Lab receives scientific award for Kallikrein research
          The Blaber Lab has been awarded the E.K. Frey-E. Werle Commemorative Gold Medal. This medal "is awarded to scientists who have made outstanding contributions to our knowledge of the role of the kallikrein-kinin system (KKS) and related subjects in health and disease over decades, so that their research achievements have significantly influenced the developments in the field".

          Dec 2008

          Dr. Hyesook Yoon manuscript accepted for publication
          Dr. Hyesook Yoon (recent PhD graduate from the Blaber Lab) has had her manuscript entitled "A Completed KLK Activome Profile: Investigation of Activation Profiles of KLK9, 10 and 15" accepted for publication in Biological Chemistry. This report completes the characterization of the ability of the members of the KLK family to recognize and cleave the pro-sequences of the KLKs (i.e. the KLK "activome"). Congratulations Hyesook!

          Nov 2008

          Dr. Michael Blaber/Zign, Inc. receives STTR "Phase 0" award
          Enterprise Florida is an organization in the state of Florida that provides seed funds to develop SBIR/STTR grant applications. Dr. Michael Blaber/Zign, Inc. was awarded one of these "Phase 0" grants to develop an STTR proposal entitled "Development of Second-generation Forms of Fibroblast Growth Factor-1 for Pro-angiogenic Therapy".

          Aug 2008

          Dr. Michael Blaber appointed editor of new journal
          Dr. Michael Blaber was appointed an editor of Journal of Proteins and Proteomics a new journal established by Dr. Vikash Dubey, IIT Guwahati. Details can be found here.

          PhD Graduation ceremony for Dr. Hyesook Yoon
          The graduation ceremony for Dr. Hyesook Yoon was held on August 9 at the Tallahassee Civic Center. Dr. Yoon was hooded by her PhD advisor Dr. Michael Blaber. Photos here!.

          Dr. Hyesook Yoon manuscript accepted for publication
          Recent Ph.D. graduate Dr. Hyesook Yoon's manuscript entitled "Activation Profiles of Human Kallikrein-related Peptidases by Proteases of the Thrombostasis Axis " has been accepted for publication in Protein Science. This study details how proteases that regulate coagulation and clot lysis can also activate members of the human kallikrein-related peptidase family, thus connecting the function of two major protease families. Congratulations Hyesook!

          Dr. Michael Blaber travels to Brazil
          Dr. Michael Blaber was invited to give a talk at the Federal University of Sao Paulo, Brazil, as a guest of Dr. Luiz Juliano, a pioneer in the field of human kallikrein-related peptidases. Pictures from the trip can be found here.

          July 2008

          Dr. Maria Juliano manuscript accepted for publication
          Dr. Maria Juliano's manuscript entitled "S1?and S2?Subsite Specificities of Human Plasma Kalikrein and Tissue Kallikrein 1 on the Hydrolysis of Peptides Derived from Bradykinin Domain of Human Kininogen" has been accepted for publication in Biological Chemistry. This study reports that S1?and S2?subsites of KLK1 and HPK show peculiarities that are observed with substrates containing the amino acid sequence of human kinonogen. Dr. Michael Blaber and Sachiko Blaber are coauthors on this study.

          Ms. Hyesook Yoon successfully defends Ph.D. thesis
          Ms. Hyesook Yoon, a graduate student in the Blaber Lab, successfully defended her Ph.D. thesis Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases. Pictures of Hyesook's defense can be found here. Dr. Yoon will continue her training as a Postdoctoral Fellow in the Lab of Dr. Eleftherios Diamandis, University of Toronto. Congratulations Hyesook!

          Dr. Gulsah Sanli named one of the top 5 Women in Science in Turkey
          Dr. Gulsah Sanli (PhD student in the Blaber Lab 1998-2002), Assistant Professor of Chemistry, Izmir Institute of Technology, was recently recognized as one of the top 5 Women in Science in Turkey. A picture of Gulsah at the awards ceremony can be found here. Congratulations Gulsah!

          May 2008

          Dr. Michael Blaber to serve on Kallikrein meeting Advisory Board
          Dr. Michael Blaber has been invited to serve on the International Scientific Advisory Board of the 3rd International Symposium on Tissue Kallikreins and Kallikrein-related Peptidases , to be held in Munich, Germany, Sep 16-19, 2009. Kallikreins are a family of proteases with emerging impact in human health, and this meeting is the premier meeting for the field.

          Dr. Jihun Lee receives Finn Wold Award
          Dr. Jihun Lee, postdoctoral researcher in the Blaber Lab, has received a Finn Wold Award, which provides support to attend the 22nd Annual Symposium of The Protein Society and present results of her research on b-turn structures in protein folding. Congratulations Jihun!

          April 2008

          Blaber Lab research featured in TechJournal South
          Research in the Blaber Lab on FGF-1 mutants and their potential application in pro-angiogenic therapy for coronary heart disease was featured in the April edition of TechJournal South. A link to the article can be found here.

          Blaber Lab research featured on WFSU/NPR radio
          Research in the Blaber Lab on FGF-1 mutants and their potential application in pro-angiogenic therapy for coronary heart disease was featured this month on radio broadcasts on WFSU and NPR radio stations. An MP3 file of the broadcast can be found here.

          Mr. Liam Longo awarded two undergraduate research fellowships
          Mr. Liam Longo, an FSU undergraduate student, was awarded both a Florida State University Undergraduate Research and Creative Endeavors (URACE) Summer Award, and a James R. Fisher Fellowship. These awards, totalling $4,000, will provide full-time support for Liam's on-going research into the folding mechanism of the FGF-1 protein in the Blaber Lab during the summer 2008 semester. Congratulations Liam!

          Mar 2008

          Dr. Michael Blaber invited to the Japan Atomic Energy Agency (JAEA)
          Dr. Blaber will spend one week in March in Tokai, Japan, as the guest of Dr. Ryota Kuroki, Molecular Structural Biology Leader-Drug Target Protein Group, Quantum Beam Science Directorate, Japan Atomic Energy Agency. Dr. Kuroki is a leader in neutron diffraction studies of protein solvation and hydrogen-bonding (more information here). Drs. Kuroki and Blaber are collaborating on neutron diffraction studies of FGF-1. Pictures can be found here.

          Ms. Hyehyun Hwang, M.S., joins Blaber lab as Research Assistant
          Ms. Hyehyun Hwang, formerly from ENZYTech Ltd., Daejeon Korea, joins the Blaber lab as a Research Assistant. Ms. Hwang will provide experimental and administrative assistance to the research programs in the lab, and her experience in cell-based assay and expression systems will provide additional support in these areas. Welcome Hyehyun!

          Dr. Luciano Puzer, Ph.D., joins Blaber lab as Visiting Professor
          Dr. Luciano Puzer, Assistant Professor, Laboratory of Molecular Biology, Department of Genetics and Evolution, Federal University of So Carlos, SP, Brazil, has joined the Blaber lab as a visiting professor for 6 months. Dr. Puzer is interested in kallikrein-related peptidases (KLKs) and will be collaborating on production and characterization of members of this important family of peptidases. Welcome Luciano!

          Dr. Michael Blaber appointed to the Scientific Advisory Board of CardioVascular BioTherapeutics Inc.
          CVBT Inc. is a biopharmaceutical company performing clinical and pre-clinical studies of the application of FGF-1 in novel "angiogenic therapy" to treat various types of ischemic disease. The structural and biophysical properties of proteins play an important part in their biological activity, and the Blaber lab is a leader in structural biology and biophysical studies of FGF-1. Information on CVBT's Scientific Advisory Board can be found here.

          Feb 2008

          Dr. Eijiro Honjo manuscript accepted for publication
          Dr. Eijiro Honjo's manuscript entitiled "Mutagenesis of the Crystal Contact of Acidic Fibroblast Growth Factor" has been accepted for publication in the Journal of Synchrotron Radiation. Dr. Honjo is a researcher in the lab of Dr. Ryota Kuroki, a leader in neutron diffraction studies of protein solvation and hydrogen-bonding. This study describes a mutagenesis approach to increase the size of FGF-1 crystals to enable neutron diffraction studies. Drs. Akshaya Meher and Michael Blaber are coauthors on this study.

          Dr. Jihun Lee manuscript accepted for publication
          Dr. Jihun Lee's manuscript entitiled "A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I b-turn Motif" has been accepted for publication in the Journal of Molecular Biology. This report, containing a comprehensive structure, stability and folding study of 28 mutations of fibroblast growth factor-1, identifies a logical OR relationship for the Asx residues in the Asx-Pro-Asx-Gly b-turn motif in stabilizing the turn.

          Jan 2008

          Dr. George Georgiou manuscript accepted for publication
          Dr. George Georgiou's manuscript entitiled "The Substrate Specificity of Human Kallikrein 1 and 6 Determined by Phage Display" has been accepted for publication in Protein Science. Sachiko Blaber, Gurunathan Laxmikanthan (former graduate student) and Dr. Michael Blaber are coauthors on this study which characterizes the preferred recognition cleavage sequence of KLK1 and KLK6 using a phage-display methodology.

          Dec 2007

          Ms. Hyesook Yoon and Dr. Jihun Lee featured on FSU International Center
          Ms Hyesook Yoon (graduate student) and Dr. Jihun Lee (postdoctoral fellow), both members of the Blaber Lab, were featured researchers on the FSU International Center web site. Details can be found here.

          Dr. Michael Blaber invited to serve on NIH study section
          Dr. Michael Blaber received an invitation to serve as an ad hoc member of the Macromolecular Structure and Function Study Section of the NIH at its February 7-8 2008 meeting in Long Beach, CA. Such peer-review meetings are invaluable in understanding the NIH grant review process and the current areas of research interest supported by the NIH.

          Nov 2007

          Dr. Michael Blaber receives FSU Innovator Award
          Dr. Michael Blaber received an FSU Innovator Award at the recent FSU Innovator Reception honoring those faculty involved in the development of intellectual property. Dr. Blaber was recognised for his patent applications associated with the development of novel mutants of fibroblast growth factor for application in angiogenic therapy. Further details can be found here, and a picture of Dr. Blaber receiving his award from Vice President of Research Dr. Kirby Kemper can be found here.

          Dr. Thomas Stegmann visits FSU
          Dr. Thomas Stegmann, a cardiac surgeon pioneering the application of angiogenic therapy to the treatment of vascular stenosis was the invited speaker for the "Grand Rounds" of the College of Medicine on Nov 1 2007. Dr. Stegmann's procedure utilizes human FGF-1, and several mutants of FGF-1 produced in the Blaber Lab may be of interest as "2nd Generation" forms in angiogenic therapy. A picture of Dr. Stegmann with members of the Blaber Lab can be found here.

          Oct 2007

          Blaber Lab members attend 2nd ISK meeting in Greece
          The 2nd International Symposium on Kallikreins and Kallikrein-Related Peptidases was held Oct 16-18 in Santorini, Greece. Dr. Michael Blaber gave a lecture entitled "Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases (KLK's)". The meeting was also attended by Ms. Hyesook Yoon and Ms. Sachiko Blaber. Hyesook presented a poster detailing her studies of the human KLK activome (in press in JBC), and Sachiko gave a poster detailing the autolytic regulation of KLK-6 (published earlier this year in Biochemistry). Pictures from the meeting can be found here.

          Aug 2007

          Ms. Hyesook Yoon manuscript accepted for publication
          Ms. Hyesook Yoon's manuscript entitled "Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases" has been accepted for publication in Journal of Biological Chemistry. This study characterizes the specificity profile of the mature KLK's for the 15 different KLK propeptide sequences, and elucidates potential KLK activation cascades.

          June 2007

          Dr. Michael Blaber receives "Outstanding Senior Faculty Researcher" award
          At the College of Medicine faculty awards ceremony, Dr. Michael Blaber was awarded the "Outstanding Senior Faculty Researcher" award for 2006-2007. This achievement reflects the hard work and accomplishments of the students, postdocs and technicians in the Blaber Lab; thank you!

          May 2007

          Dr. Vikash Dubey manuscript accepted for publication
          Dr. Dubey's manuscript entitled "Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N- and C-terminus b-strand Interactions" has been accepted for publication in Journal of Molecular Biology. This report describes specific point mutations in the adjacent N- and C-termini b-strands that provide substantial increases in thermostability.

          Apr 2007

          PhD Graduation ceremony for Dr. Jihun Lee
          The graduation ceremony for Dr. Jihun Lee was held on April 27 at the Tallahassee Civic Center. Dr. Lee was hooded by her PhD advisor Dr. Michael Blaber. Photo here!.

          Mar 2007

          Blaber Lab signs contract research agreement
          The Blaber Lab has entered into a contract research agreement with CardioVascular BioTherapeutics, a leading-edge Biotechnology company in angiogenic therapy. The research agreement provides research support for the development and characterization of "second generation" forms of fibroblast growth factor-1 (FGF-1) for application in angiogenic therapy.

          Ms. Jihun Lee successfully defends Ph.D. thesis
          Ms. Jihun Lee, a graduate student in the Blaber Lab, successfully defended her Ph.D. thesis Characterization of the Effects of b -turn Sequence on Protein Stability, Folding Kinetics, Functionality and Turn Structure. Dr. Lee will continue her training as a Postdoctoral Fellow in the Blaber Lab, pursuing her interest in the study of protein turn structure. Congratulations Jihun!

          Ms. Sachiko Blaber manuscript accepted for publication
          Ms. Sachiko Blaber's manuscript entitled "The autolytic regulation of human kallikrein-related peptidase 6" has been accepted for publication in Biochemistry. This study concludes that KLK6 autolytic activity is primarily targeted towards inactivation and a distinct protease is required for activation.

          Feb 2007

          Ms. Hyesook Yoon passes PhD oral qualifing exam
          Ms. Hyesook Yoon, a graduate student in the Blaber Lab, successfully passed her PhD oral qualfying exam and has now advanced to candidacy for the PhD degree in Chemistry and Biochemistry. Congratulations to Hyesook!

          Blaber Lab awarded NIH research grant
          The Blaber Lab has been awarded a 3-year NIH R15 research grant entitled Interactions between CNS-specific human kallikreins and the PA system in inflammation. The project will focus of the role of specific members of the human kallikrein family in the progression of inflammatory demyelination in the central nervous system (as occurs with Multiple Sclerosis).

          Jan 2007

          Dr. Michael Blaber promoted to Full Professor
          FSU president T.K. Wetherell approved promotion of Dr. Blaber to Full Professor, effective the 2007 academic year. This promotion reflects the achievements of the outstanding students, postdocs and technicians who have contributed to the success of the Blaber Lab over the past 13 years (special thanks to the current lab personnel).

          Sep 2006

          Mr. Gurunathan Laxmikanthan successfully defends Ph.D. thesis
          Mr. Gurunathan, a graduate student in the Blaber Lab, successfully defended his Ph.D. thesis An Insight into the Structure, Function and Activation Cascades of the Classical Human Kallikreins. Dr. Laxmikanthan will pursue a Postdoctoral position at Brown University. Congratulations Guru!

          June 2006

          Dr. Morley Hollenberg manuscript accepted for publication
          Another manuscript, Proteinase-activated receptors (pars): targets for kallikrein signalling in collaboration with Dr. Morley Hollenberg (pioneer in the area of protease-activated receptors) has been accepted for publication in the Journal of Biological Chemistry. Dr. Michael Blaber and Ms. Sachiko I. Blaber are coauthors in this study.

          May 2006

          Blaber Lab receives research grant from the American Heart Association
          The Blaber Lab has been awarded a three-year research grant from the American Heart Association to study the x-ray structure and receptor-binding properties of mutant forms of human fibroblast growth factor-1. The mutant forms being studied exhibit enhanced properties in regards to their ability to stimulate cells to grow. The study of these mutants will help in the design of "second generation" forms of FGF-1 for angiogenic therapy in the treatment of "no option" heart patients. Thanks to all the hard-working lab personnel who made this grant possible!

          Dr. Vikash Dubey obtains tenured faculty position
          Dr. Vikash Dubey, a postdoc in the Blaber lab since 2004, has received an offer of a tenured Assistant Professorship in the Department of Biotechnology at the prestigious Indian Institute of Technology, Guwahati campus. Congratulations to Vikash!

          Apr 2006

          Ms. Nikki Held graduates with MS
          Ms. Nikki held graduated from the Blaber Lab with an MS degree in Chemistry in the Spring 2006 semester.

          Mar 2006

          Dr. Morley Hollenberg manuscript accepted for publication
          Dr. Morley Hollenberg has been studying the role of human kallikreins in the activation of protease-activated receptors. His manuscript entitled Kallikrein-Mediated Cell Signaling: Targeting Proteinase-Activated Receptors (PARs)1 has been accepted for publication in Biological Chemistry. Dr. Michael Blaber and Ms. Sachiko I. Blaber are coauthors in this study.

          Dr. Blaber appointed to FSU Human Subjects Institutional Review Board
          The Human Subjects IRB reviews research applications from FSU researchers that involve human subjects. The IRB ensures that appropriate ethical standards are upheld for research involving human subjects.

          Jan 2006

          Dr. Ake Lundwall manuscript accepted for publication
          Dr. Ake Lundwall has organized a group of experts in the kallikrein field to propose a nomenclature for the kallikrein family. This effort derived from discussions at the 1st International Symposium on Kallikreins, held in Lausanne, Switzerland in 2005. Dr. Blaber participated in this effort, and is a coauthor on this manuscript which was recently accepted for publication in Biological Chemistry.

          Dec 2005

          Dr. Luiz Juliano manuscript accepted for publication
          Dr. Luiz Juliano, a recognized expert in the study of human kallikreins at the Department of Biophysics, Universidade Federal de Sao Paulo, has been collaborating with the Blaber Lab to study the ability of K6 to activate protease-activated receptors (PAR's). This work, authored by Dr. Juliano, was recently accepted for publication in the Journal of Biological Chemistry.

          Nov 2005

          Dr. Blaber receives FSU Innovator Recognition
          Dr. Blaber was one of several faculty and staff members to be recognized by Dr. Kirby Kemper, Vice President of Research, for contributions towards the licencing of intellectual property generated at FSU. Dr. Blaber was acknowledged for his development and licencing of web-based tutorials for teaching concepts in undergraduate Chemistry.

          Oct 2005

          Dr. Blaber reappointed to Protein Science Editorial Advisory Board
          Dr. Blaber has previously served a three-year term as an Editorial Advisory Board member to Protein Science. This month he was invited by the Editor of the journal to serve a second three-year term (through 2008). Dr. Blaber has published articles in Protein Science as a graduate student, postdoc and P.I., and it is a real privilege to serve on the EAB for another term. Best wishes for the continued success of the journal!

          Sep 2005

          Ms. Jihun Lee manuscript accepted for publication
          Ms. Lee, a graduate student in the Blaber Lab, had an article entitled "Conversion of type I 4:6 to 3:5 b-turn types in human acidic fibroblast growth factor: effects upon structure, stability, folding and mitogenic function" accepted, with no requested revisions, for publication in the journal Proteins: Structure, Function and Bioinformatics.

          Blaber Lab Retreat in Sandestin
          The Blaber Lab went on a much-needed 2-day retreat to Sandestin, FL. Images of the trip can be found here.

          Blaber Lab first to receive research grant in FSU GAP program
          The Blaber Lab was awarded the first of a new type of grant from the FSU Office of Research, known as a GAP grant. These grants are intended to provide proof-of-concept data in the development of intellectual property of potential commercial interest. The Blaber Lab submitted a proposal to study heparin and receptor-binding properties of mutants of human fibroblast growth factor 1 with enhanced functional properties. Such mutants have potential application in "angiogenic therapy" for the development of neo-vasculature in the treatment of ischemia. CardioVascular BioTherapeutics is one such company pursuing the use of FGF-1 in angiogenic therapy.

          Blaber Lab moves to brand new research facilities in College of Medicine at Florida State University
          After starting his academic career and spending 11 challenging and rewarding years in the Department of Chemistry & Biochemistry at FSU, Dr. Blaber accepted an offer of a faculty position in the new College of Medicine at FSU. This next phase in his career will no doubt be as challengind and exciting as the first! His teaching responsibilities in the College of Medicine include training of medical students; several of which were undergraduates in Dr. Blaber's Chemistry and Biochemistry courses at FSU.

          July 2005

          Ms. Hyesook Yoon joins Blaber Lab
          Ms. Hyesook Yoon has joined the Blaber Lab as a Graduate Research Assistant. Ms. Yoon's research efforts will initially focus upon the biochemistry and enzymology of human kallikreins.

          May 2005

          Dr. Vikash Dubey manuscript accepted for publication
          Dr. Vikash Dubey, a Postdoctoral Researcher in the Blaber Lab, had an article entitled "Redesigning symmetry-related "mini-core" regions of FGF-1 to increase primary structure symmetry: thermodynamic and functional consequences of structural symmetry" accepted for publication in the journal Protein Science.

          March 2005

          Blaber Lab awarded Pilot Project Grant from National Multiple Sclerosis Society
          The Blaber Lab was awarded a grant (PP1113) to study the "Identification of Activation Cascades Involving Human Kallikrein 6" from the National Multiple Sclerosis Society. The research will help to understand the role of this novel CNS-specific protease in Multiple Sclerosis.

          Home | Curriculum Vita | Publications | Research | Teaching | Personnel | Prior Personnel | DSCfit Software | Links
          Copyright 2005. All rights reserved.
          Ź
          Baidu
          sogou
          《完美世界》txt全集 古风小说 小说网 完结小说 辰东完美世界有声小说 已完本玄幻小说排行榜 小说排行榜 古风名字 择天记 好看的课外书 yy玄幻小说排行榜完本 小说改编的网页游戏 有声 我欲封天 重生之毒妃 梅果 小说 好看的历史书籍推荐 盗墓笔记txt全集下载 完美世界辰东 古风 欢乐颂 玄幻小说 古风小说 君子以泽 玄幻小说排行榜完本 天下 高月 小说 网络小说排行榜 好看的电视剧 君子以泽 有声小说 《完美世界》txt全集 完美世界有声小说全集 玄幻小说完本 怎样写网络小说 完美世界辰东小说下载 好看的小说完本推荐 如何发布网络小说 旷世神医 雪鹰领主 完美世界 欢乐颂小说 完结小说 有声小说下载 已完结小说排行榜 我吃西红柿 怎么写网络小说 小说排行榜 已完本玄幻小说排行榜 盗墓笔记同人小说 兽性总裁的爱奴 小说 完美世界 辰东 小说 完美世界有声小说全集 盛世嫡妃 凤轻 小说 有声 殿上欢 盗墓笔记小说txt下载 魔天记 忘语 小说 完美世界辰东 玄幻小说完本 殿上欢 武道至尊 帝临 小说 好看的玄幻小说 琅琊榜 海宴 小说 完美世界官网 玄幻小说排行榜完本 完美世界小说下载 小说网 辰东 好看的电视剧 如何发布网络小说 玄幻小说排行榜完本 国际完美世界下载 古风名字 完美世界有声小说 最好看的小说排行 我欲封天 耳根 小说 雪鹰领主 完美世界官网 欢乐颂小说 如何发布网络小说 古风名字 欢乐颂第一季免费阅读 神武八荒 一颗 小说 盗墓笔记全集 欢乐颂小说在线阅读 女人书籍排行榜 斗破苍穹续集 盗墓笔记小说下载 好看的小说完本推荐 我吃西红柿 玄幻小说排行榜 重生之毒妃 梅果 小说 好看的历史书籍推荐 好看的玄幻小说 将夜 猫腻 小说 完美世界txt下载 盗墓笔记第二季 盗墓笔记全集 欢乐颂小说txt 完美世界小说下载 好看的小说 君子以泽 yy玄幻小说排行榜完本 女强穿越玄幻完结小说 我吃西红柿 《完美世界》txt全集 完美世界txt下载 穿越小说排行榜 重生之毒妃 梅果 小说 遮天 辰东 小说 大主宰 如何发布网络小说 小说阅读网 完美世界 大主宰 盗墓笔记同人小说 盛世嫡妃 凤轻 小说 古风 完美世界辰东 怎么写网络小说 小说阅读网 大主宰 天蚕土豆 小说 完美世界前传下载 盗墓笔记txt全集下载 小说 手机推荐排行榜 遮天 盗墓笔记有声小说 古风君子以泽 将夜 猫腻 小说 完美世界官网 耳根 择天记 辰东 玄幻小说改编的电视剧 遮天 古风君子以泽 完美世界辰东 完美世界小说txt下载 有声读物 欢乐颂小说txt 辰东 好看的言情小说 豆豆小说阅读网 我欲封天 耳根 小说零 穿越小说完本 盗墓笔记第二季 天下 高月 小说 欢乐颂小说 好看的课外书 欢乐颂小说结局是什么 完美的世界 1993 电影 我吃西红柿 盗墓笔记同人小说 手机推荐排行榜 天蚕土豆 盗墓笔记txt全集下载 梦入神机 好看的言情小说 玄幻小说排行榜 女强穿越玄幻完结小说 有声小说 完结小说 盗墓笔记小说 辰东 怎么写网络小说 豆豆小说阅读网 完美世界小说下载 盛世嫡妃 凤轻 小说 好看的小说完本推荐 女人书籍排行榜 盛世嫡妃 凤轻 小说 玄幻小说排行榜 完美世界小说下载 欢乐颂第三季 完结小说排行榜 灵域 完美世界国际版下载 完美世界 千年殇 我欲封天txt下载 完美世界 辰东 小说 辰东 魔天记 忘语 小说 女人书籍排行榜 梦入神机 如何发布网络小说 穿越小说完本 大主宰 天蚕土豆 小说 大主宰 天蚕土豆 好看的小说 唐家三少 管理书籍排行榜 我欲封天 耳根 小说零 完美世界辰东 完美世界前传下载 小说阅读网免费小说 玄幻小说排行榜 已完结小说排行榜 盗墓笔记小说 大主宰之灵路天蚕土豆 我欲封天 耳根 小说 懒人听书 完美世界txt下载 旷世神医 小说阅读网站 大主宰txt全集下载 小说排行榜 如何发布网络小说 玄幻小说改编的电视剧 女人书籍排行榜 我吃西红柿 盗墓笔记 大主宰txt全集下载 完结小说排行榜 大主宰之灵路天蚕土豆 yy玄幻小说排行榜完本 穿越小说排行榜 完美世界小说下载 听中国有声小说 穿越小说完本 完美的世界 1993 电影 完美世界小说下载 盗墓笔记 豆豆小说阅读网 女人书籍排行榜 手机推荐排行榜 遮天 重生之毒妃 梅果 小说 《完美世界》txt全集 兽性总裁的爱奴 斗破苍穹续集 盗墓笔记全集 有声小说 盗墓笔记全集 重生之毒妃 梅果 小说 有声 我欲封天 耳根 小说零 完美世界辰东 《完美世界》txt全集 新寡妇村传奇 有声小说打包下载 古风小说 古风小说 君子以泽 梦入神机 小说网 大主宰之灵路天蚕土豆 手机推荐排行榜 最好看的小说排行 遮天 千年殇 完美世界 辰东 小说 豆豆小说阅读网 重生之毒妃 梅果 小说 小说排行榜 小说网 懒人听书 绝色狂妃 仙魅 小说 完美世界国际版下载 完美的世界 1993 电影 穿越小说完本 小说阅读器 小说排行榜 有声小说 已完结小说排行榜 盗墓笔记小说txt下载 小说排行榜 我欲封天 遮天 遮天 辰东 小说笔趣阁 完美世界 辰东 小说 有声小说 怎样写网络小说 我欲封天 耳根 小说 殿上欢 小说排行榜 有声读物 盗墓笔记小说下载 有声小说打包下载 盗墓笔记有声小说 辰东 盗墓笔记txt全集下载 完美的世界 1993 电影 完美世界国际版下载 欢乐颂第三季 手机推荐排行榜 性爱有声小说在线收听 yy玄幻小说排行榜完本 怎么写网络小说 有声小说在线收听网 古风名字 完美世界有声小说 旷世神医 小说阅读网 盛世嫡妃 凤轻 小说 完美世界辰东 我欲封天 耳根 小说 欢乐颂小说结局是什么 小说 盗墓笔记同人小说 小说改编的网页游戏 盗墓笔记小说txt下载 我欲封天 耳根 小说 有声小说在线收听网 完美世界有声小说 完美世界有声小说 怎么写网络小说 遮天 我欲封天 耳根 小说 天下 高月 小说 小说排行榜完结版 好看的玄幻小说 如何发布网络小说 古风名字 殿上欢 遮天 我欲封天 耳根 小说 古风小说 大主宰 天蚕土豆 小说 殿上欢 斗破苍穹续集 怎样写网络小说 yy玄幻小说排行榜完本 好看的历史书籍推荐 斗破苍穹续集 天蚕土豆 梦入神机 欢乐颂小说txt 手机推荐排行榜 怎样写网络小说 小说排行榜完结版 大主宰 天蚕土豆 我欲封天 有声读物 好看的小说 完美世界小说下载 最好看的小说排行 有声小说下载 盗墓笔记全集 天下 高月 小说 琅琊榜 海宴 小说 网络小说排行榜 神墓 辰东 小说 古风 完美世界辰东 完美世界txt全集下载 盗墓笔记 古风小说 君子以泽 小说排行榜 完美世界小说下载 完美世界辰东 神武八荒 一颗 小说 斗破苍穹续集 小说阅读网 遮天 武道至尊 帝临 小说 小说排行榜 好看的言情小说 我欲封天 耳根 小说零 欢乐颂小说结局是什么 完美世界辰东小说下载 盗墓笔记小说下载 盗墓笔记第二季 好看的课外书 风凌天下 完美的世界 1993 电影 欢乐颂小说结局是什么 欢乐颂第一季 欢乐颂小说在线阅读 我欲封天 小说阅读网站 女强穿越玄幻完结小说 好看的玄幻小说 神武八荒 一颗 小说 古风小说 君子以泽 好看的历史书籍推荐 我吃西红柿 大主宰txt全集下载 玄幻小说 盗墓笔记小说下载 雪鹰领主 我欲封天txt下载 盗墓笔记 小说排行榜 完美世界txt下载 武道至尊 帝临 小说 yy玄幻小说排行榜完本 我欲封天 耳根 小说 完美世界txt全集下载 辰东完美世界有声小说 魔天记 忘语 小说 盗墓笔记有声小说 盗墓笔记有声小说 我欲封天 耳根 小说零 小说阅读网免费小说 怎样写网络小说 兽性总裁的爱奴 完美世界前传下载 完美世界txt下载 玄幻小说排行榜完本 好看的课外书 如何发布网络小说 管理书籍排行榜 完美世界辰东 择天记 绝色狂妃 仙魅 小说 有声 天下 高月 小说 小说阅读网站 欢乐颂第三季 国际完美世界下载 古风名字 完美世界前传下载 遮天 小说改编的网页游戏 欢乐颂小说结局是什么 我欲封天txt下载 辰东 已完结小说排行榜 殿上欢 完美世界txt下载 小说 好看的课外书 琅琊榜 海宴 小说 欢乐颂第二季 懒人听书 玄幻小说改编的电视剧 大主宰 好看的言情小说 欢乐颂第一季 好看的课外书 好看的小说 好看的历史书籍推荐 殿上欢 听中国有声小说 完结小说 完美世界前传下载 神武八荒 一颗 小说 欢乐颂第三季 盗墓笔记小说 欢乐颂小说txt 欢乐颂第二季 斗破苍穹续集 将夜 猫腻 小说 盗墓笔记有声小说 君子以泽 欢乐颂小说 玄幻小说排行榜完本 唐家三少 盗墓笔记小说txt下载 琅琊榜 海宴 小说 欢乐颂小说结局是什么 小说网 盗墓笔记小说txt下载 盗墓笔记全集 小说 完美世界辰东 将夜 猫腻 小说 盗墓笔记 大主宰之灵路天蚕土豆 旷世神医 《完美世界》txt全集 武道至尊 帝临 小说 兽性总裁的爱奴 玄幻小说完本 有声小说下载 完美世界国际版下载 欢乐颂小说结局是什么 玄幻小说排行榜完本 已完本玄幻小说排行榜 遮天 辰东 欢乐颂第三季 盗墓笔记小说下载 国际完美世界下载 已完结小说排行榜 完美世界国际版下载 小说 盛世嫡妃 凤轻 小说 欢乐颂第二季 完美的世界 1993 电影 盗墓笔记txt全集下载 完美世界辰东 梦入神机 欢乐颂第二季 魔天记 忘语 小说 好看的课外书 小说阅读网 好看的言情小说 盛世嫡妃 凤轻 小说 琅琊榜 海宴 小说 君子以泽 古风小说 君子以泽 欢乐颂小说txt 斗破苍穹续集 《完美世界》txt全集 梦入神机 好看的课外书 管理书籍排行榜 《完美世界》txt全集 欢乐颂第一季免费阅读 完美世界 辰东 小说 玄幻小说完本 我欲封天 耳根 小说 如何发布网络小说 欢乐颂第一季免费阅读 旷世神医 已完结小说排行榜 琅琊榜 海宴 小说 完美世界辰东小说下载 完美世界前传下载 盗墓笔记同人小说 欢乐颂第三季 小说改编的网页游戏 遮天 君子以泽 唐家三少 穿越小说排行榜 小说阅读网站 怎么写网络小说 好看的历史书籍推荐 完美世界前传下载 小说 玄幻小说排行榜完本 我欲封天txt下载 我欲封天 好看的课外书 有声小说打包下载 完美世界有声小说 盗墓笔记小说 盗墓笔记第二季 言情小说 君子以泽 女人书籍排行榜 盗墓笔记全集 武道至尊 帝临 小说 《完美世界》txt全集 怎样写网络小说 完美世界辰东小说下载 盗墓笔记全集 大主宰 小说阅读网站 好看的言情小说 盗墓笔记小说全集 我欲封天 遮天 辰东 小说 完美世界 武道至尊 帝临 小说 手机推荐排行榜 盗墓笔记小说 古风小说 君子以泽 盗墓笔记 神墓 辰东 小说 完美的世界 1993 电影 斗破苍穹续集 欢乐颂第一季 《完美世界》txt全集 我欲封天 懒人听书 欢乐颂小说 穿越小说完本 大主宰 天蚕土豆 小说 听中国有声小说 盗墓笔记有声小说 欢乐颂小说txt 盗墓笔记小说下载 好看的言情小说 完美世界前传下载 绝色狂妃 仙魅 小说 完美世界txt全集下载 辰东 欢乐颂 欢乐颂第二季 欢乐颂第一季 盗墓笔记第二季 小说阅读网 有声小说 完美世界txt全集下载 玄幻小说排行榜 懒人听书 《完美世界》txt全集 小说阅读网 我欲封天 耳根 小说零 懒人听书 武道至尊 帝临 小说 管理书籍排行榜 古风名字 欢乐颂第一季免费阅读 遮天 网络小说排行榜 小说阅读网 豆豆小说阅读网 小说阅读网站 将夜 猫腻 小说 有声读物 遮天 千年殇 完美世界txt下载 古风小说 君子以泽 听中国有声小说 辰东 我欲封天 耳根 小说零 我欲封天txt下载 国际完美世界下载 盗墓笔记小说全集 大主宰之灵路天蚕土豆 大主宰 天蚕土豆 武道至尊 帝临 小说 女强穿越玄幻完结小说 管理书籍排行榜 大主宰txt全集下载 网络小说排行榜 小说网 我欲封天 耳根 小说 盗墓笔记 欢乐颂第三季 欢乐颂第二季 大主宰 懒人听书 懒人听书 性爱有声小说在线收听 天下 高月 小说 盗墓笔记小说 玄幻小说 殿上欢 好看的课外书 如何发布网络小说 有声小说 完美世界辰东 遮天 辰东 小说笔趣阁 灵域 完美世界前传下载 穿越小说排行榜 梦入神机 完美世界 辰东 小说 国际完美世界下载 大主宰 天蚕土豆 盗墓笔记小说txt下载 欢乐颂小说结局是什么 盗墓笔记第二季 殿上欢 完美世界官网 盗墓笔记小说下载 好看的玄幻小说 手机推荐排行榜 已完结小说排行榜 《完美世界》txt全集 我欲封天 耳根 小说 好看的小说 君子以泽 盛世嫡妃 凤轻 小说 辰东 盗墓笔记 欢乐颂 完美世界txt下载 怎样写网络小说 新寡妇村传奇 小说网 完美世界 辰东 小说 君子以泽 辰东完美世界有声小说 古风名字 好看的课外书 梦入神机 盗墓笔记txt全集下载 将夜 猫腻 小说 天蚕土豆 盗墓笔记有声小说 盛世嫡妃 凤轻 小说 已完结小说排行榜 好看的历史书籍推荐 盗墓笔记同人小说 已完本玄幻小说排行榜 盛世嫡妃 凤轻 小说 好看的小说完本推荐 古风君子以泽 我欲封天txt下载 穿越小说排行榜 玄幻小说完本 好看的小说完本推荐 古风小说 完美世界前传下载 欢乐颂 好看的电视剧 盗墓笔记小说 魔天记 忘语 小说 玄幻小说排行榜 完美世界txt下载 小说阅读网站 有声小说 小说阅读网 好看的课外书 欢乐颂小说txt 盗墓笔记txt全集下载 有声小说 梦入神机 盛世嫡妃 凤轻 小说 好看的课外书 最好看的小说排行 玄幻小说排行榜完本 魔天记 忘语 小说 完结小说 《完美世界》txt全集 欢乐颂第一季 完美世界国际版下载 大主宰之灵路天蚕土豆 遮天 已完本玄幻小说排行榜 重生之毒妃 梅果 小说 有声小说打包下载 大主宰 天蚕土豆 小说阅读器 完美世界辰东 手机推荐排行榜 新寡妇村传奇 网络小说排行榜 完美世界小说txt下载 我欲封天 耳根 小说零 魔天记 忘语 小说 如何发布网络小说 官场小说排行榜 欢乐颂第二季 完结小说 手机推荐排行榜 完美世界小说下载 小说 盗墓笔记小说下载 欢乐颂小说txt 穿越小说排行榜 女人书籍排行榜 完美世界辰东小说下载 大主宰之灵路天蚕土豆 将夜 猫腻 小说 完美的世界 1993 电影 豆豆小说阅读网 盗墓笔记同人小说 古风 有声小说在线收听网 唐家三少 大主宰 天蚕土豆 小说 遮天 完美世界txt下载 有声小说打包下载 完结小说排行榜 玄幻小说完本 耳根 古风小说 君子以泽 完美世界辰东 小说阅读网免费小说 网络小说排行榜 我欲封天 耳根 小说零 神墓 辰东 小说 完美世界官网 兽性总裁的爱奴 欢乐颂小说txt 盗墓笔记 穿越小说完本 雪鹰领主 完美世界txt下载 魔天记 忘语 小说 大主宰 天蚕土豆 盗墓笔记小说 遮天 小说阅读网 君子以泽 欢乐颂第三季 完结小说排行榜 盗墓笔记 殿上欢 完美世界txt下载 盗墓笔记第二季 君子以泽 玄幻小说排行榜 完美世界 辰东 小说 完美世界txt下载 好看的玄幻小说 天蚕土豆 怎样写网络小说 欢乐颂小说在线阅读 大主宰之灵路天蚕土豆 听中国有声小说 盗墓笔记小说txt下载 欢乐颂小说txt 已完本玄幻小说排行榜 梦入神机 梦入神机 小说网 网络小说排行榜 盛世嫡妃 凤轻 小说 神墓 辰东 小说 好看的历史书籍推荐 小说排行榜 完结小说 有声读物 重生之毒妃 梅果 小说 盗墓笔记小说全集 女强穿越玄幻完结小说 如何发布网络小说 怎么写网络小说 欢乐颂小说结局是什么 我欲封天txt下载 小说阅读网站 天蚕土豆 盗墓笔记有声小说 遮天 辰东 小说 我吃西红柿 小说网 天蚕土豆 小说 重生之毒妃 梅果 小说 完美世界辰东 我吃西红柿 天蚕土豆 好看的小说完本推荐 我欲封天txt下载 盗墓笔记小说全集 完美的世界 1993 电影 女人书籍排行榜 性爱有声小说在线收听 盗墓笔记小说txt下载 旷世神医 有声小说打包下载 懒人听书 好看的小说 女人书籍排行榜 大主宰 天蚕土豆 最好看的小说排行 有声 言情小说 君子以泽 最好看的小说排行 重生之毒妃 梅果 小说 完美世界txt全集下载 斗破苍穹续集 完美世界txt全集下载 小说排行榜完结版 小说阅读网 网络小说排行榜 辰东全部小说 完美世界前传下载 盗墓笔记第二季 遮天 辰东 小说笔趣阁 神武八荒 一颗 小说 小说阅读器 好看的言情小说 有声小说下载 神武八荒 一颗 小说 古风 小说排行榜 完结小说 玄幻小说 如何发布网络小说 已完结小说排行榜 新寡妇村传奇 最好看的小说排行 性爱有声小说在线收听 《完美世界》txt全集 女人书籍排行榜 盗墓笔记小说 有声小说下载 完美世界 辰东 小说 手机推荐排行榜 欢乐颂小说txt 我欲封天 耳根 小说 小说排行榜 完美世界辰东 好看的言情小说 遮天 神武八荒 一颗 小说 欢乐颂小说txt 盗墓笔记小说txt下载 天域苍穹 辰东完美世界有声小说 性爱有声小说在线收听 有声小说下载 好看的电视剧 怎样写网络小说 网络小说排行榜 女人书籍排行榜 将夜 猫腻 小说 性爱有声小说在线收听 欢乐颂小说结局是什么 完美世界 辰东 小说 已完本玄幻小说排行榜 好看的玄幻小说 yy玄幻小说排行榜完本 灵域 欢乐颂第二季 遮天 遮天 辰东 小说笔趣阁 yy玄幻小说排行榜完本 盗墓笔记 斗破苍穹续集 古风小说 雪鹰领主 听中国有声小说 绝色狂妃 仙魅 小说 天下 高月 小说 盗墓笔记有声小说 穿越小说排行榜 辰东 兽性总裁的爱奴 魔天记 忘语 小说 有声小说在线收听网 魔天记 忘语 小说 小说排行榜 有声 欢乐颂小说结局是什么 已完本玄幻小说排行榜 欢乐颂第三季 天蚕土豆 殿上欢 玄幻小说 小说阅读器 遮天 辰东 小说笔趣阁 将夜 猫腻 小说 我欲封天 耳根 小说零 有声小说打包下载 穿越小说排行榜 好看的历史书籍推荐 琅琊榜 海宴 小说 听中国有声小说 怎样写网络小说 有声读物 好看的言情小说 完美世界官网 兽性总裁的爱奴 绝色狂妃 仙魅 小说 古风名字 怎么写网络小说 豆豆小说阅读网 盗墓笔记 小说网 玄幻小说排行榜完本 欢乐颂小说 完美世界辰东小说下载 欢乐颂小说txt 旷世神医 欢乐颂第二季 灵域 已完结小说排行榜 完美世界有声小说 手机推荐排行榜 我欲封天 耳根 小说 完结小说排行榜 玄幻小说完本 最好看的小说排行 我吃西红柿 古风小说 君子以泽 豆豆小说阅读网 小说 古风名字 盗墓笔记第二季 完美世界有声小说 魔天记 忘语 小说 《完美世界》txt全集 我欲封天 完美世界前传下载 玄幻小说改编的电视剧 遮天 穿越小说排行榜 小说 已完结小说排行榜 国际完美世界下载 我欲封天 耳根 小说 如何发布网络小说 欢乐颂第三季 懒人听书 有声小说下载 好看的玄幻小说 欢乐颂第一季 玄幻小说排行榜完本 欢乐颂小说txt 怎样写网络小说 盛世嫡妃 凤轻 小说 欢乐颂第一季免费阅读 已完结小说排行榜 玄幻小说 遮天 辰东 小说 天下 高月 小说 天蚕土豆 我欲封天 耳根 小说 盗墓笔记小说txt下载 最好看的小说排行 欢乐颂第二季 有声 有声小说打包下载 遮天 辰东 小说笔趣阁 好看的电视剧 好看的小说完本推荐 盗墓笔记txt全集下载 天蚕土豆 旷世神医 完美世界国际版下载 欢乐颂小说在线阅读 怎么写网络小说 完美世界小说下载 完结小说排行榜 玄幻小说 天域苍穹 有声小说 小说排行榜 玄幻小说排行榜完本 手机推荐排行榜 完美世界小说下载 殿上欢 已完本玄幻小说排行榜 完美世界有声小说 欢乐颂小说结局 盗墓笔记 欢乐颂小说txt 小说排行榜 玄幻小说排行榜完本 我欲封天txt下载 完美世界txt下载 古风小说 官场小说排行榜 遮天 好看的历史书籍推荐 盗墓笔记有声小说 小说网 魔天记 忘语 小说 天域苍穹 将夜 猫腻 小说 欢乐颂 有声小说下载 如何发布网络小说 盗墓笔记txt全集下载 盗墓笔记小说 小说阅读网站 盗墓笔记有声小说 我欲封天txt下载 性爱有声小说在线收听 我欲封天 耳根 小说 小说排行榜 完美世界辰东小说下载 怎么写网络小说 完美世界前传下载 完美世界 辰东 小说 手机推荐排行榜 懒人听书 遮天 辰东 小说笔趣阁 择天记 小说阅读网 完美世界小说下载 怎么写网络小说 玄幻小说排行榜完本 完结小说 好看的玄幻小说 我欲封天 耳根 小说 完美世界txt全集下载 女强穿越玄幻完结小说 盗墓笔记第二季 好看的电视剧 古风小说 欢乐颂小说结局是什么 耳根 完美世界txt全集下载 豆豆小说阅读网 好看的玄幻小说 玄幻小说改编的电视剧 完美世界有声小说全集 遮天 辰东 小说笔趣阁 小说阅读网免费小说 完美世界前传下载 玄幻小说排行榜完本 已完本玄幻小说排行榜 我欲封天txt下载 完结小说排行榜 欢乐颂小说结局是什么 管理书籍排行榜 将夜 猫腻 小说 我欲封天 耳根 小说 完美的世界 1993 电影 我吃西红柿 兽性总裁的爱奴 好看的小说 古风君子以泽 小说阅读网站 完美世界辰东 完美世界辰东小说下载 梦入神机 如何发布网络小说 完结小说 好看的小说完本推荐 千年殇 我欲封天 耳根 小说零 欢乐颂小说结局是什么 好看的小说完本推荐 玄幻小说排行榜完本 玄幻小说完本 完美世界txt下载 有声小说 好看的课外书 有声读物 欢乐颂小说结局是什么 兽性总裁的爱奴 懒人听书 完美世界辰东 大主宰 天蚕土豆 小说 辰东完美世界有声小说 古风 小说网 盗墓笔记txt全集下载 雪鹰领主 将夜 猫腻 小说 盛世嫡妃 凤轻 小说 网络小说排行榜 琅琊榜 海宴 小说 小说改编的网页游戏 穿越小说完本 新寡妇村传奇 有声读物 听中国有声小说 完美的世界 1993 电影 完结小说 盗墓笔记txt全集下载 欢乐颂第一季免费阅读 灵域 神武八荒 一颗 小说 小说网 豆豆小说阅读网 大主宰txt全集下载 欢乐颂第一季 玄幻小说排行榜 梦入神机 遮天 辰东 小说笔趣阁 女强穿越玄幻完结小说 大主宰之灵路天蚕土豆 盛世嫡妃 凤轻 小说 完结小说排行榜 穿越小说排行榜 完美世界有声小说全集 女人书籍排行榜 已完结小说排行榜 辰东完美世界有声小说 玄幻小说排行榜完本 兽性总裁的爱奴 盗墓笔记小说下载 完美世界辰东 欢乐颂第二季 欢乐颂第二季 绝色狂妃 仙魅 小说 《完美世界》txt全集 怎么写网络小说 绝色狂妃 仙魅 小说 好看的玄幻小说 欢乐颂小说在线阅读 完美世界 玄幻小说 听中国有声小说 小说网 完美世界小说下载 斗破苍穹续集 有声小说下载 盗墓笔记txt全集下载 有声读物 性爱有声小说在线收听 完美世界有声小说 完美世界辰东小说下载 我吃西红柿 女强穿越玄幻完结小说 千年殇 小说阅读网 完美世界有声小说 遮天 雪鹰领主 小说阅读网站 豆豆小说阅读网 殿上欢 完美世界辰东 盗墓笔记txt全集下载 玄幻小说 欢乐颂小说 玄幻小说完本 欢乐颂第一季免费阅读 好看的电视剧 怎样写网络小说 完结小说 我欲封天txt下载 已完结小说排行榜 完美世界国际版下载 欢乐颂第三季 欢乐颂小说结局 欢乐颂小说结局是什么 完美世界txt全集下载 辰东完美世界有声小说 遮天 怎样写网络小说 君子以泽 天蚕土豆 魔天记 忘语 小说 玄幻小说排行榜完本 择天记 欢乐颂 盗墓笔记第二季 大主宰txt全集下载 天蚕土豆 小说阅读网 我欲封天 耳根 小说零 盗墓笔记txt全集下载 完美世界txt全集下载 有声小说 好看的小说 小说排行榜完结版 小说排行榜完结版 小说排行榜 我欲封天 辰东 斗破苍穹续集 完美的世界 1993 电影 怎么写网络小说 耳根 有声 怎样写网络小说 玄幻小说改编的电视剧 灵域 古风名字 我吃西红柿 完美世界有声小说全集 我欲封天txt下载 欢乐颂第一季 有声读物 耳根 小说阅读器 有声小说 武道至尊 帝临 小说 好看的玄幻小说 小说 小说阅读器 完美的世界 1993 电影 小说阅读网站 完美世界辰东 好看的电视剧 古风小说 君子以泽 完美世界 辰东 小说 好看的历史书籍推荐 遮天 穿越小说完本 大主宰 天蚕土豆 如何发布网络小说 辰东完美世界有声小说 完美世界小说下载 国际完美世界下载 小说阅读网站 小说排行榜 古风名字 完美世界辰东小说下载 小说阅读网站 已完结小说排行榜 完结小说排行榜 遮天 完美世界txt下载 怎么写网络小说 古风 天下 高月 小说 欢乐颂第二季 重生之毒妃 梅果 小说 盗墓笔记txt全集下载 好看的言情小说 有声小说下载 完美世界有声小说全集 遮天 辰东 小说 有声读物 完美世界小说下载 穿越小说完本 古风名字 完结小说 完美世界有声小说全集 已完本玄幻小说排行榜 穿越小说排行榜 殿上欢 完美世界有声小说全集 完美世界 已完结小说排行榜 《完美世界》txt全集 怎样写网络小说 完美世界前传下载 玄幻小说完本 小说阅读网 完结小说 古风 完美世界txt全集下载 古风名字 完美世界前传下载 豆豆小说阅读网 我欲封天txt下载 梦入神机 欢乐颂小说txt 官场小说排行榜 古风君子以泽 有声读物 好看的电视剧 小说阅读器 我吃西红柿 女人书籍排行榜 天下 高月 小说 欢乐颂小说在线阅读 耳根 盗墓笔记小说全集 完美世界辰东 古风名字 完美的世界 1993 电影 女强穿越玄幻完结小说 大主宰 完结小说排行榜 完结小说排行榜 择天记 完美世界国际版下载 欢乐颂第二季 完美世界前传下载 欢乐颂 大主宰之灵路天蚕土豆 小说网 斗破苍穹续集 唐家三少 我欲封天 耳根 小说 小说阅读器 完美世界txt全集下载 遮天 欢乐颂小说结局 《完美世界》txt全集 盗墓笔记 盛世嫡妃 凤轻 小说 有声小说 穿越小说排行榜 懒人听书 欢乐颂小说txt 盗墓笔记全集 盗墓笔记小说txt下载 好看的小说 欢乐颂小说结局是什么 古风名字 玄幻小说完本 琅琊榜 海宴 小说 玄幻小说排行榜 君子以泽 欢乐颂第一季 大主宰之灵路天蚕土豆 管理书籍排行榜 盗墓笔记有声小说 我欲封天 耳根 小说 女强穿越玄幻完结小说 小说阅读器 小说阅读网免费小说 大主宰之灵路天蚕土豆 《完美世界》txt全集 小说排行榜完结版 完美世界辰东 好看的历史书籍推荐 好看的小说 玄幻小说排行榜完本 完美世界txt全集下载 完美世界txt全集下载 欢乐颂第二季 性爱有声小说在线收听 言情小说 君子以泽 完美世界 辰东 小说 遮天 辰东 小说 玄幻小说完本 性爱有声小说在线收听 天下 高月 小说 女强穿越玄幻完结小说 有声小说下载 辰东完美世界有声小说 有声小说打包下载 欢乐颂第一季免费阅读 天下 高月 小说 欢乐颂第一季免费阅读 完美世界 辰东 小说 殿上欢 手机推荐排行榜 天下 高月 小说 我欲封天 耳根 小说零 耳根 古风小说 言情小说 君子以泽 我吃西红柿 我欲封天txt下载 好看的言情小说 yy玄幻小说排行榜完本 玄幻小说 重生之毒妃 梅果 小说 古风名字 欢乐颂小说结局 穿越小说完本 耳根 君子以泽 古风小说 君子以泽 穿越小说完本 好看的历史书籍推荐 玄幻小说排行榜完本 完美世界有声小说全集 完美世界 辰东 小说 欢乐颂第二季 言情小说 君子以泽 重生之毒妃 梅果 小说 将夜 猫腻 小说 千年殇 大主宰txt全集下载 大主宰 盗墓笔记全集 天蚕土豆 欢乐颂小说txt 绝色狂妃 仙魅 小说 完结小说 玄幻小说完本 小说网 完美世界官网 欢乐颂第一季免费阅读 梦入神机 小说排行榜完结版 完结小说排行榜 yy玄幻小说排行榜完本 完美世界有声小说 欢乐颂 yy玄幻小说排行榜完本 网络小说排行榜 玄幻小说排行榜完本 《完美世界》txt全集 最好看的小说排行 欢乐颂第一季 有声小说 玄幻小说改编的电视剧 天蚕土豆 完美世界辰东 盛世嫡妃 凤轻 小说 完美的世界 1993 电影 梦入神机 国际完美世界下载 盗墓笔记 小说排行榜 官场小说排行榜 如何发布网络小说 好看的课外书 盗墓笔记全集 小说网 小说网 殿上欢 绝色狂妃 仙魅 小说 重生之毒妃 梅果 小说 欢乐颂小说结局是什么 辰东 雪鹰领主 小说排行榜完结版 官场小说排行榜 魔天记 忘语 小说 绝色狂妃 仙魅 小说 欢乐颂小说结局是什么 旷世神医 好看的言情小说 有声小说打包下载 遮天 yy玄幻小说排行榜完本 欢乐颂小说结局是什么 斗破苍穹续集 绝色狂妃 仙魅 小说 天蚕土豆 盗墓笔记小说全集 怎么写网络小说 旷世神医 完美世界有声小说 听中国有声小说 小说网 千年殇 有声 盗墓笔记小说下载 欢乐颂小说结局是什么 完美世界官网 穿越小说排行榜 好看的言情小说 欢乐颂小说结局是什么 玄幻小说完本 遮天 欢乐颂第一季 女人书籍排行榜 完美世界辰东小说下载 盗墓笔记有声小说 怎样写网络小说 重生之毒妃 梅果 小说 盗墓笔记txt全集下载 我欲封天 盗墓笔记小说txt下载 女人书籍排行榜 盗墓笔记第二季 耳根 天下 高月 小说 好看的言情小说 好看的课外书 玄幻小说排行榜完本 大主宰 天蚕土豆 琅琊榜 海宴 小说 欢乐颂小说txt 豆豆小说阅读网 言情小说 君子以泽 斗破苍穹续集 欢乐颂第一季 古风名字 怎样写网络小说 武道至尊 帝临 小说 完美世界国际版下载 完美世界txt全集下载 我欲封天 千年殇 古风小说 盗墓笔记同人小说 欢乐颂第一季 怎么写网络小说 有声 玄幻小说改编的电视剧 女强穿越玄幻完结小说 小说阅读网免费小说 盗墓笔记第二季 yy玄幻小说排行榜完本 小说阅读器 小说 我欲封天 耳根 小说零 遮天 辰东 小说 完美世界有声小说 完美世界辰东 小说阅读器 雪鹰领主 小说阅读网站 古风小说 斗破苍穹续集 辰东全部小说 神武八荒 一颗 小说 穿越小说完本 小说 大主宰 性爱有声小说在线收听 好看的言情小说 如何发布网络小说 穿越小说排行榜 新寡妇村传奇 盗墓笔记全集 盗墓笔记第二季 已完结小说排行榜 完结小说 好看的玄幻小说 有声小说下载 有声小说打包下载 我吃西红柿 武道至尊 帝临 小说 兽性总裁的爱奴 魔天记 忘语 小说 我欲封天 耳根 小说 欢乐颂小说txt 魔天记 忘语 小说 好看的课外书 盗墓笔记小说下载 大主宰 天蚕土豆 小说 耳根 完结小说 唐家三少 君子以泽 完结小说排行榜 魔天记 忘语 小说 完美世界有声小说全集 完美世界 辰东 小说 怎么写网络小说 古风名字 小说网 好看的小说完本推荐 盗墓笔记有声小说 辰东完美世界有声小说 完美世界 辰东 小说 风凌天下 我欲封天 盗墓笔记全集 好看的小说 君子以泽 千年殇 好看的小说完本推荐 将夜 猫腻 小说 遮天 管理书籍排行榜 好看的课外书 国际完美世界下载 官场小说排行榜 有声小说在线收听网 武道至尊 帝临 小说 好看的小说完本推荐 性爱有声小说在线收听 完美世界txt下载 我欲封天 耳根 小说零 完美世界辰东 女强穿越玄幻完结小说 完美世界辰东小说下载 绝色狂妃 仙魅 小说 玄幻小说完本 盗墓笔记小说下载 大主宰之灵路天蚕土豆 辰东 懒人听书 择天记 官场小说排行榜 辰东 盗墓笔记 小说阅读网 完美世界 辰东 小说 女人书籍排行榜 盗墓笔记小说下载 完美世界前传下载 女人书籍排行榜 管理书籍排行榜 我欲封天 耳根 小说零 盗墓笔记小说下载 天下 高月 小说 天域苍穹 女人书籍排行榜 玄幻小说完本 欢乐颂第一季免费阅读 小说阅读网 性爱有声小说在线收听 穿越小说完本 天下 高月 小说 长生界 辰东 小说 好看的玄幻小说 完美世界辰东 欢乐颂小说在线阅读 小说网 我欲封天 耳根 小说 大主宰 择天记 好看的历史书籍推荐 完美世界有声小说全集 手机推荐排行榜 完美世界辰东 盛世嫡妃 凤轻 小说 天域苍穹 玄幻小说改编的电视剧 有声小说下载 小说阅读网免费小说 完结小说 梦入神机 穿越小说完本 小说排行榜完结版 好看的玄幻小说 琅琊榜 海宴 小说 手机推荐排行榜 古风 辰东完美世界有声小说 我欲封天txt下载 《完美世界》txt全集 大主宰 天蚕土豆 小说 玄幻小说完本 古风小说 完美的世界 1993 电影 欢乐颂第二季 古风 绝色狂妃 仙魅 小说 千年殇 玄幻小说排行榜完本 风凌天下 小说阅读网免费小说 完美世界小说下载 千年殇 千年殇 古风名字 小说 盗墓笔记全集 管理书籍排行榜 完美世界前传下载 将夜 猫腻 小说 遮天 小说阅读网站 神武八荒 一颗 小说 穿越小说排行榜 我欲封天 耳根 小说零 完美世界有声小说 完美世界辰东小说下载 小说阅读网 好看的小说 君子以泽 官场小说排行榜 豆豆小说阅读网 大主宰 天蚕土豆 小说 小说阅读网 《完美世界》txt全集 小说阅读网 旷世神医 盗墓笔记 欢乐颂第一季 小说改编的网页游戏 女人书籍排行榜 好看的电视剧 欢乐颂第一季 怎样写网络小说 好看的课外书 遮天 辰东 小说 怎么写网络小说 殿上欢 已完结小说排行榜 怎么写网络小说 盗墓笔记txt全集下载 有声读物 管理书籍排行榜 盗墓笔记小说下载 完美世界辰东小说下载 有声小说在线收听网 管理书籍排行榜 玄幻小说完本 有声读物 网络小说排行榜 性爱有声小说在线收听 完结小说排行榜 天蚕土豆 欢乐颂小说txt 有声读物 最好看的小说排行 殿上欢 我欲封天txt下载 管理书籍排行榜 我欲封天 耳根 小说零 怎么写网络小说 好看的小说 盗墓笔记第二季 玄幻小说排行榜完本 《完美世界》txt全集 欢乐颂小说结局是什么 管理书籍排行榜 盗墓笔记第二季 豆豆小说阅读网 完美世界前传下载 君子以泽 完美世界辰东 盗墓笔记全集 好看的课外书 雪鹰领主 完美世界有声小说全集 好看的言情小说 盗墓笔记有声小说 古风小说 君子以泽 完美世界前传下载 完结小说排行榜 遮天 辰东 小说 欢乐颂小说结局是什么 我欲封天 完美世界有声小说 我吃西红柿 好看的小说完本推荐 欢乐颂小说txt 如何发布网络小说 盗墓笔记小说txt下载 完结小说排行榜 古风名字 玄幻小说完本 重生之毒妃 梅果 小说 好看的小说完本推荐 国际完美世界下载 欢乐颂小说结局 好看的小说完本推荐 琅琊榜 海宴 小说 择天记 小说阅读网免费小说 好看的玄幻小说 完美世界有声小说全集 小说阅读网 遮天 辰东 小说笔趣阁 将夜 猫腻 小说 旷世神医 好看的言情小说 遮天 辰东 小说 玄幻小说改编的电视剧 完美世界小说txt下载 大主宰之灵路天蚕土豆 国际完美世界下载 盗墓笔记全集 欢乐颂第二季 盗墓笔记同人小说 重生之毒妃 梅果 小说 玄幻小说排行榜 有声读物 魔天记 忘语 小说 已完结小说排行榜 好看的小说完本推荐 玄幻小说排行榜完本 有声 完美世界 辰东 小说 旷世神医 古风 兽性总裁的爱奴 我欲封天 耳根 小说零 君子以泽 完美世界国际版下载 完美的世界 1993 电影 玄幻小说 遮天 穿越小说完本 欢乐颂小说 古风小说 小说阅读网免费小说 完结小说排行榜 我欲封天 耳根 小说 君子以泽 玄幻小说排行榜 好看的小说完本推荐 欢乐颂 小说排行榜 完美世界辰东小说下载 好看的历史书籍推荐 如何发布网络小说 欢乐颂小说结局 遮天 天域苍穹 懒人听书 盗墓笔记第二季 国际完美世界下载 完美世界辰东 穿越小说排行榜 武道至尊 帝临 小说 大主宰之灵路天蚕土豆 欢乐颂小说 完美世界 辰东 小说 完结小说排行榜 如何发布网络小说 怎样写网络小说 古风名字 好看的言情小说 好看的小说完本推荐 天下 高月 小说 魔天记 忘语 小说 天下 高月 小说 玄幻小说排行榜 好看的玄幻小说 已完结小说排行榜 完美世界国际版下载 懒人听书 大主宰之灵路天蚕土豆 好看的小说完本推荐 国际完美世界下载 玄幻小说排行榜完本 玄幻小说排行榜 完美世界txt下载 最好看的小说排行 盗墓笔记 绝色狂妃 仙魅 小说 穿越小说排行榜 怎样写网络小说 完美世界辰东 好看的小说 管理书籍排行榜 手机推荐排行榜 小说排行榜 古风名字 管理书籍排行榜 有声读物 有声读物 好看的历史书籍推荐 小说阅读网站 欢乐颂第三季 玄幻小说完本 古风君子以泽 我吃西红柿 完美世界 辰东 小说 好看的玄幻小说 完结小说排行榜 重生之毒妃 梅果 小说 玄幻小说 唐家三少 好看的课外书 小说 盗墓笔记小说下载 我欲封天 耳根 小说 斗破苍穹续集 如何发布网络小说 天域苍穹 天蚕土豆 如何发布网络小说 好看的电视剧 遮天 yy玄幻小说排行榜完本 辰东 yy玄幻小说排行榜完本 好看的玄幻小说 女人书籍排行榜 武道至尊 帝临 小说 完美世界 重生之毒妃 梅果 小说 欢乐颂小说在线阅读 豆豆小说阅读网 好看的课外书 琅琊榜 海宴 小说 完美世界txt全集下载 我欲封天 耳根 小说 欢乐颂小说txt 我吃西红柿 完结小说排行榜 盗墓笔记小说txt下载 我欲封天 耳根 小说零 盛世嫡妃 凤轻 小说 辰东完美世界有声小说 天蚕土豆 我欲封天 耳根 小说 《完美世界》txt全集 梦入神机 兽性总裁的爱奴 盗墓笔记小说下载 唐家三少 已完本玄幻小说排行榜 择天记 将夜 猫腻 小说 神墓 辰东 小说 欢乐颂小说 欢乐颂 梦入神机 绝色狂妃 仙魅 小说 完美世界国际版下载 网络小说排行榜 完美世界官网 殿上欢 魔天记 忘语 小说 欢乐颂小说txt 已完结小说排行榜 欢乐颂小说在线阅读 古风名字 国际完美世界下载 性爱有声小说在线收听 长生界 辰东 小说 小说阅读网免费小说 小说排行榜完结版 我欲封天 大主宰之灵路天蚕土豆 小说网 有声小说下载 好看的小说完本推荐 玄幻小说改编的电视剧 旷世神医 懒人听书 官场小说排行榜 大主宰txt全集下载 完美世界有声小说全集 欢乐颂第二季 完美世界有声小说全集 我欲封天txt下载 小说 欢乐颂 管理书籍排行榜 小说排行榜 完美世界txt全集下载 耳根 我欲封天txt下载 听中国有声小说 择天记 我欲封天 耳根 小说 盗墓笔记小说txt下载 小说排行榜 大主宰 天蚕土豆 小说 管理书籍排行榜 耳根 辰东 好看的玄幻小说 盗墓笔记全集 神武八荒 一颗 小说 玄幻小说排行榜 完美世界官网 耳根 盗墓笔记全集 欢乐颂第二季 风凌天下 完美世界 辰东 小说 如何发布网络小说 我欲封天 耳根 小说 好看的历史书籍推荐 手机推荐排行榜 玄幻小说完本 怎样写网络小说 欢乐颂 最好看的小说排行 盗墓笔记全集 欢乐颂小说在线阅读 有声读物 完美世界国际版下载 怎样写网络小说 完美世界小说下载 性爱有声小说在线收听 女强穿越玄幻完结小说 小说网 穿越小说完本 梦入神机 我欲封天 耳根 小说零 古风小说 君子以泽 完美世界小说txt下载 管理书籍排行榜 小说排行榜 小说阅读器 盗墓笔记小说下载 网络小说排行榜 穿越小说完本 盗墓笔记第二季 将夜 猫腻 小说 完美世界前传下载 完美世界前传下载 小说排行榜 玄幻小说完本 已完本玄幻小说排行榜 神武八荒 一颗 小说 手机推荐排行榜 琅琊榜 海宴 小说 盗墓笔记小说txt下载 小说网 兽性总裁的爱奴 盗墓笔记 欢乐颂第二季 旷世神医 女强穿越玄幻完结小说 怎么写网络小说 辰东 遮天 完美世界 辰东 小说 怎么写网络小说 盗墓笔记小说 君子以泽 武道至尊 帝临 小说 懒人听书 完美世界官网 穿越小说完本 完美世界辰东 古风 手机推荐排行榜 欢乐颂小说结局是什么 绝色狂妃 仙魅 小说 千年殇 小说阅读网 辰东 玄幻小说排行榜完本 完美世界有声小说全集 有声小说下载 有声读物 琅琊榜 海宴 小说 穿越小说排行榜 大主宰 天蚕土豆 小说 完美世界国际版下载 大主宰之灵路天蚕土豆 好看的玄幻小说 小说阅读网站 小说阅读网站 完美世界辰东 欢乐颂小说 yy玄幻小说排行榜完本 有声读物 女人书籍排行榜 小说阅读网站 遮天 国际完美世界下载 官场小说排行榜 古风小说 君子以泽 小说阅读网 懒人听书 神墓 辰东 小说 好看的小说 君子以泽 古风名字 好看的历史书籍推荐 完结小说排行榜 已完本玄幻小说排行榜 有声小说 灵域 好看的历史书籍推荐 将夜 猫腻 小说 盗墓笔记同人小说 新寡妇村传奇 完结小说 《完美世界》txt全集 玄幻小说改编的电视剧 兽性总裁的爱奴 辰东 管理书籍排行榜 官场小说排行榜 盛世嫡妃 凤轻 小说 我欲封天 耳根 小说 完美世界有声小说 小说阅读网站 欢乐颂小说 手机推荐排行榜 怎样写网络小说 风凌天下 玄幻小说排行榜完本 古风名字 遮天 辰东 小说笔趣阁 完美世界 辰东 小说 好看的小说 辰东 国际完美世界下载 盗墓笔记小说txt下载 好看的玄幻小说 好看的课外书 完美世界官网 玄幻小说完本 有声小说 盗墓笔记全集 欢乐颂第一季 已完结小说排行榜 完结小说 有声 小说排行榜完结版 完美世界 辰东 小说 小说阅读网站 国际完美世界下载 大主宰 武道至尊 帝临 小说 古风名字 小说阅读器 我欲封天 耳根 小说 好看的言情小说 欢乐颂 玄幻小说完本 完美世界小说txt下载 完美世界小说下载 绝色狂妃 仙魅 小说 小说网 好看的小说 yy玄幻小说排行榜完本 玄幻小说排行榜完本 完美世界辰东 怎么写网络小说 新寡妇村传奇 君子以泽 欢乐颂小说结局 完美世界有声小说 豆豆小说阅读网 欢乐颂 《完美世界》txt全集 小说 完美世界官网 完美世界有声小说全集 小说排行榜完结版 魔天记 忘语 小说 小说阅读网 完美世界小说下载 雪鹰领主 梦入神机 神武八荒 一颗 小说 盗墓笔记 殿上欢 我欲封天txt下载 盗墓笔记有声小说 已完结小说排行榜 大主宰之灵路天蚕土豆 我欲封天txt下载 完美世界txt下载 耳根 斗破苍穹续集 盛世嫡妃 凤轻 小说 梦入神机 大主宰 天蚕土豆 梦入神机 好看的小说 君子以泽 天下 高月 小说 古风名字 完美世界小说下载 盗墓笔记 yy玄幻小说排行榜完本 已完结小说排行榜 有声小说在线收听网 玄幻小说排行榜完本 天蚕土豆 盗墓笔记小说 殿上欢 大主宰 天蚕土豆 小说 怎样写网络小说 完美世界小说下载 性爱有声小说在线收听 我欲封天txt下载 玄幻小说改编的电视剧 《完美世界》txt全集 欢乐颂小说结局是什么 官场小说排行榜 完美世界 辰东 小说 怎么写网络小说 古风名字 古风小说 君子以泽 绝色狂妃 仙魅 小说 有声读物 小说阅读网免费小说 欢乐颂小说txt 盗墓笔记同人小说 雪鹰领主 玄幻小说完本 我吃西红柿 盗墓笔记txt全集下载 盛世嫡妃 凤轻 小说 绝色狂妃 仙魅 小说 已完结小说排行榜 魔天记 忘语 小说 欢乐颂第一季 怎样写网络小说 完美世界有声小说全集 完美世界前传下载 管理书籍排行榜 有声小说下载 欢乐颂第一季免费阅读 玄幻小说排行榜完本 有声小说下载 听中国有声小说 遮天 神武八荒 一颗 小说 好看的言情小说 兽性总裁的爱奴 斗破苍穹续集 神武八荒 一颗 小说 欢乐颂小说在线阅读 神武八荒 一颗 小说 盗墓笔记txt全集下载 好看的历史书籍推荐 辰东全部小说 完美世界国际版下载 完美世界txt全集下载 欢乐颂小说结局是什么 我欲封天 耳根 小说 官场小说排行榜 将夜 猫腻 小说 怎么写网络小说 管理书籍排行榜 遮天 辰东 完美世界 辰东 小说 完美世界有声小说 已完本玄幻小说排行榜 欢乐颂第一季 大主宰 天蚕土豆 完美世界txt全集下载 有声读物 小说阅读网 玄幻小说 古风小说 已完结小说排行榜 国际完美世界下载 遮天 辰东 小说 大主宰 好看的历史书籍推荐 欢乐颂小说结局是什么 辰东完美世界有声小说 女人书籍排行榜 大主宰 大主宰 天蚕土豆 盗墓笔记第二季 有声 完美世界辰东小说下载 欢乐颂小说结局 小说阅读网免费小说 性爱有声小说在线收听 有声小说在线收听网 小说排行榜完结版 旷世神医 千年殇 管理书籍排行榜 穿越小说完本 小说阅读网站 完结小说 已完本玄幻小说排行榜 古风小说 君子以泽 雪鹰领主 欢乐颂第二季 有声小说打包下载 懒人听书 完美世界前传下载 小说排行榜 重生之毒妃 梅果 小说 玄幻小说排行榜完本 欢乐颂 风凌天下 古风名字 兽性总裁的爱奴 网络小说排行榜 完美世界辰东 已完结小说排行榜 玄幻小说排行榜 我欲封天txt下载 大主宰txt全集下载 盗墓笔记同人小说 已完本玄幻小说排行榜 完结小说排行榜 管理书籍排行榜 完美世界辰东小说下载 yy玄幻小说排行榜完本 欢乐颂第一季 绝色狂妃 仙魅 小说 旷世神医 官场小说排行榜 已完本玄幻小说排行榜 欢乐颂第一季 遮天 辰东 小说 辰东全部小说 好看的历史书籍推荐 完美世界txt全集下载 完美世界前传下载 唐家三少 完美世界 辰东 小说 琅琊榜 海宴 小说 完美的世界 1993 电影 辰东 穿越小说完本 耳根 怎么写网络小说 唐家三少 玄幻小说 欢乐颂第二季 网络小说排行榜 君子以泽 好看的玄幻小说 梦入神机 豆豆小说阅读网 殿上欢 斗破苍穹续集 琅琊榜 海宴 小说 欢乐颂小说结局是什么 听中国有声小说 神武八荒 一颗 小说 完美世界辰东小说下载 小说阅读器 欢乐颂小说结局是什么 网络小说排行榜 遮天 完美世界 辰东 小说 完美世界有声小说 神武八荒 一颗 小说 琅琊榜 海宴 小说 已完结小说排行榜 好看的课外书 大主宰 有声读物 殿上欢 性爱有声小说在线收听 最好看的小说排行 完美世界国际版下载 好看的玄幻小说 盛世嫡妃 凤轻 小说 盗墓笔记txt全集下载 完结小说排行榜 我吃西红柿 盗墓笔记小说下载 好看的玄幻小说 完美世界国际版下载 小说 有声小说打包下载 豆豆小说阅读网 辰东全部小说 盗墓笔记有声小说 欢乐颂小说结局 手机推荐排行榜 小说 好看的小说完本推荐 欢乐颂第一季 管理书籍排行榜 小说排行榜 怎么写网络小说 我吃西红柿 完美世界有声小说全集 重生之毒妃 梅果 小说 完美世界有声小说 辰东 玄幻小说排行榜完本 如何发布网络小说 盗墓笔记 古风 小说阅读网站 盗墓笔记全集 旷世神医 完结小说排行榜 唐家三少 好看的言情小说 小说排行榜 小说阅读网 欢乐颂第二季 完美世界国际版下载 完美世界前传下载 盗墓笔记小说全集 武道至尊 帝临 小说 小说排行榜完结版 魔天记 忘语 小说 女人书籍排行榜 小说阅读网 欢乐颂第一季 玄幻小说完本 好看的言情小说 遮天 穿越小说完本 国际完美世界下载 耳根 欢乐颂小说结局是什么 大主宰txt全集下载 盗墓笔记小说 大主宰txt全集下载 官场小说排行榜 完美世界有声小说 有声小说下载 古风 欢乐颂小说结局是什么 遮天 玄幻小说完本 网络小说排行榜 琅琊榜 海宴 小说 我欲封天 耳根 小说 我欲封天 耳根 小说 欢乐颂小说结局是什么 完美世界小说下载 小说改编的网页游戏 欢乐颂小说在线阅读 最好看的小说排行 完美世界 辰东 小说 耳根 大主宰 如何发布网络小说 盗墓笔记有声小说 绝色狂妃 仙魅 小说 梦入神机 大主宰之灵路天蚕土豆 完美世界txt全集下载 欢乐颂第二季 盗墓笔记小说txt下载 完美世界官网 我欲封天 耳根 小说 盗墓笔记小说txt下载 小说网 盗墓笔记第二季 新寡妇村传奇 小说阅读网站 完美世界有声小说 穿越小说完本 《完美世界》txt全集 小说阅读网站 盗墓笔记小说txt下载 我欲封天 耳根 小说零 手机推荐排行榜 完美世界有声小说 盗墓笔记同人小说 国际完美世界下载 古风 女人书籍排行榜 如何发布网络小说 玄幻小说完本 如何发布网络小说 最好看的小说排行 我欲封天 完美世界txt全集下载 新寡妇村传奇 豆豆小说阅读网 言情小说 君子以泽 小说 完美世界辰东小说下载 殿上欢 完美世界小说下载 大主宰 天蚕土豆 小说 完美世界小说下载 懒人听书 《完美世界》txt全集 穿越小说排行榜 好看的历史书籍推荐 好看的小说完本推荐 玄幻小说 欢乐颂第三季 我欲封天txt下载 古风君子以泽 小说阅读网 完美世界 完美世界 辰东 小说 古风小说 君子以泽 手机推荐排行榜 完美世界有声小说 玄幻小说完本 遮天 小说排行榜完结版 完结小说排行榜 女强穿越玄幻完结小说 武道至尊 帝临 小说 完美世界txt全集下载 古风名字 怎么写网络小说 梦入神机 小说阅读网 懒人听书 完美世界小说下载 玄幻小说排行榜完本 玄幻小说 完美世界有声小说 新寡妇村传奇 完美世界有声小说 欢乐颂第一季 欢乐颂小说 武道至尊 帝临 小说 管理书籍排行榜 魔天记 忘语 小说 欢乐颂小说结局是什么 小说排行榜完结版 完美世界前传下载 已完结小说排行榜 完美世界辰东 怎么写网络小说 长生界 辰东 小说 《完美世界》txt全集 完美世界小说下载 欢乐颂第二季 小说改编的网页游戏 完美世界小说txt下载 管理书籍排行榜 小说 盗墓笔记有声小说 完美世界小说下载 完美世界有声小说 完美世界小说txt下载 《完美世界》txt全集 玄幻小说排行榜完本 欢乐颂第三季 大主宰之灵路天蚕土豆 盗墓笔记同人小说 有声小说在线收听网 盗墓笔记 长生界 辰东 小说 遮天 盗墓笔记同人小说 我欲封天txt下载 完美世界小说下载 旷世神医 兽性总裁的爱奴 好看的小说 yy玄幻小说排行榜完本 欢乐颂小说结局 大主宰 天蚕土豆 小说 最好看的小说排行 我欲封天txt下载 欢乐颂第二季 玄幻小说排行榜 好看的小说 君子以泽 绝色狂妃 仙魅 小说 小说阅读网站 小说排行榜 小说网 遮天 手机推荐排行榜 有声读物 有声小说下载 欢乐颂小说结局 完美世界txt下载 玄幻小说排行榜完本 完美世界国际版下载 新寡妇村传奇 神武八荒 一颗 小说 我欲封天 耳根 小说 我欲封天txt下载 国际完美世界下载 管理书籍排行榜 穿越小说排行榜 完结小说 欢乐颂小说结局是什么 欢乐颂第一季免费阅读 懒人听书 完美世界有声小说全集 盗墓笔记全集 有声小说下载 小说阅读网 玄幻小说改编的电视剧 我欲封天 耳根 小说零 神武八荒 一颗 小说 有声读物 古风小说 有声小说下载 大主宰 天蚕土豆 小说网 小说 古风君子以泽 小说阅读网 欢乐颂小说在线阅读 古风小说 君子以泽 有声小说下载 小说排行榜 完美世界辰东小说下载 好看的言情小说 盗墓笔记小说下载 盗墓笔记同人小说 好看的小说完本推荐 懒人听书 小说网 将夜 猫腻 小说 小说 辰东 欢乐颂第一季免费阅读 已完结小说排行榜 盗墓笔记全集 管理书籍排行榜 好看的历史书籍推荐 大主宰txt全集下载 有声 我欲封天 耳根 小说 完美世界官网 耳根 兽性总裁的爱奴 大主宰之灵路天蚕土豆 我吃西红柿 完美世界辰东 yy玄幻小说排行榜完本 好看的小说 好看的历史书籍推荐 琅琊榜 海宴 小说 有声读物 欢乐颂第一季免费阅读 大主宰之灵路天蚕土豆 大主宰之灵路天蚕土豆 管理书籍排行榜 已完本玄幻小说排行榜 欢乐颂小说结局是什么 完美世界小说下载 重生之毒妃 梅果 小说 完美世界前传下载 小说阅读网免费小说 重生之毒妃 梅果 小说 好看的言情小说 我欲封天 耳根 小说零 有声 完结小说 盗墓笔记同人小说 遮天 辰东 小说笔趣阁 有声读物 有声小说在线收听网 欢乐颂第一季 盗墓笔记第二季 完美世界小说下载 大主宰之灵路天蚕土豆 天蚕土豆 如何发布网络小说 好看的课外书 如何发布网络小说 天下 高月 小说 完美世界辰东 官场小说排行榜 好看的历史书籍推荐 盗墓笔记小说下载 盗墓笔记小说txt下载 盗墓笔记小说 盗墓笔记全集 盗墓笔记txt全集下载 雪鹰领主 完美世界辰东 欢乐颂小说结局 好看的小说 君子以泽 玄幻小说排行榜 完美世界辰东小说下载 懒人听书 完美世界小说下载 小说阅读网站 古风名字 盗墓笔记小说txt下载 欢乐颂 小说阅读器 重生之毒妃 梅果 小说 武道至尊 帝临 小说 琅琊榜 海宴 小说 欢乐颂第二季 绝色狂妃 仙魅 小说 已完本玄幻小说排行榜 唐家三少 盗墓笔记有声小说 穿越小说完本 小说网 女人书籍排行榜 小说 欢乐颂小说结局是什么 听中国有声小说 完美世界有声小说 玄幻小说改编的电视剧 武道至尊 帝临 小说 新寡妇村传奇 穿越小说完本 网络小说排行榜 辰东完美世界有声小说 好看的小说完本推荐 古风小说 怎样写网络小说 我欲封天txt下载 如何发布网络小说 完美世界国际版下载 神武八荒 一颗 小说 完美世界辰东 豆豆小说阅读网 千年殇 有声读物 斗破苍穹续集 完美世界官网 好看的历史书籍推荐 听中国有声小说 《完美世界》txt全集 玄幻小说排行榜完本 遮天 辰东 小说 完美世界txt全集下载 古风小说 完美世界有声小说 管理书籍排行榜 完美世界有声小说全集 听中国有声小说 有声小说打包下载 完美世界辰东小说下载 盗墓笔记txt全集下载 辰东完美世界有声小说 辰东 已完本玄幻小说排行榜 兽性总裁的爱奴 懒人听书 耳根 小说阅读网免费小说 玄幻小说完本 千年殇 有声 完美世界txt全集下载 魔天记 忘语 小说 盗墓笔记txt全集下载 完美世界小说下载 魔天记 忘语 小说 小说排行榜 玄幻小说排行榜 将夜 猫腻 小说 遮天 欢乐颂第一季 古风小说 君子以泽 我欲封天 耳根 小说零 武道至尊 帝临 小说 怎样写网络小说 盛世嫡妃 凤轻 小说 完美世界txt下载 重生之毒妃 梅果 小说 我欲封天 耳根 小说 听中国有声小说 完结小说排行榜 欢乐颂小说 怎样写网络小说 完美世界辰东 懒人听书 小说改编的网页游戏 如何发布网络小说 如何发布网络小说 盛世嫡妃 凤轻 小说 古风 性爱有声小说在线收听 穿越小说排行榜 遮天 辰东 小说笔趣阁 小说排行榜完结版 完结小说 穿越小说排行榜 欢乐颂第三季 懒人听书 琅琊榜 海宴 小说 小说阅读网 盗墓笔记全集 已完结小说排行榜 好看的小说完本推荐 小说阅读器 大主宰 天蚕土豆 小说 欢乐颂第一季免费阅读 欢乐颂第二季 官场小说排行榜 国际完美世界下载 女人书籍排行榜 听中国有声小说 已完结小说排行榜 我吃西红柿 君子以泽 有声小说下载 千年殇 遮天 辰东 小说笔趣阁 玄幻小说完本 网络小说排行榜 好看的历史书籍推荐 管理书籍排行榜 玄幻小说完本 如何发布网络小说 古风小说 君子以泽 怎么写网络小说 如何发布网络小说 完美的世界 1993 电影 玄幻小说改编的电视剧 完美世界小说下载 已完本玄幻小说排行榜 已完结小说排行榜 欢乐颂第一季 完美世界官网 官场小说排行榜 大主宰之灵路天蚕土豆 辰东完美世界有声小说 我欲封天 耳根 小说零 魔天记 忘语 小说 小说排行榜完结版 最好看的小说排行 小说阅读器 遮天 辰东 小说笔趣阁 小说排行榜完结版 欢乐颂小说结局是什么 女人书籍排行榜 风凌天下 好看的小说完本推荐 完美世界txt下载 已完结小说排行榜 武道至尊 帝临 小说 琅琊榜 海宴 小说 玄幻小说完本 盗墓笔记 玄幻小说改编的电视剧 玄幻小说排行榜完本 好看的小说 君子以泽 手机推荐排行榜 小说阅读网免费小说 我欲封天txt下载 盛世嫡妃 凤轻 小说 小说阅读网 琅琊榜 海宴 小说 小说排行榜完结版 性爱有声小说在线收听 盛世嫡妃 凤轻 小说 小说阅读网站 管理书籍排行榜 小说阅读网 我欲封天txt下载 完美世界小说下载 怎么写网络小说 我欲封天 择天记 盗墓笔记小说txt下载 旷世神医 好看的课外书 已完本玄幻小说排行榜 有声 我欲封天txt下载 盗墓笔记txt全集下载 完美世界辰东 有声小说 好看的言情小说 我欲封天txt下载 重生之毒妃 梅果 小说 辰东 女人书籍排行榜 将夜 猫腻 小说 盗墓笔记txt全集下载 君子以泽 我吃西红柿 完美世界辰东小说下载 武道至尊 帝临 小说 我欲封天txt下载 将夜 猫腻 小说 有声小说 懒人听书 好看的小说完本推荐 盗墓笔记 完美世界 辰东 小说 懒人听书 欢乐颂第一季 我欲封天 完美世界 我欲封天 耳根 小说 完美世界辰东 好看的历史书籍推荐 雪鹰领主 欢乐颂小说结局 我欲封天 耳根 小说 yy玄幻小说排行榜完本 完美世界有声小说 玄幻小说排行榜完本 性爱有声小说在线收听 完美世界辰东 古风名字 完美世界国际版下载 好看的言情小说 盗墓笔记同人小说 盗墓笔记txt全集下载 欢乐颂第二季 盗墓笔记小说全集 玄幻小说排行榜 完美世界有声小说 君子以泽 辰东完美世界有声小说 天蚕土豆 完美世界txt全集下载 小说网 天下 高月 小说 斗破苍穹续集 玄幻小说排行榜 好看的玄幻小说 我欲封天 雪鹰领主 君子以泽 女强穿越玄幻完结小说 好看的小说完本推荐 风凌天下 如何发布网络小说 完美世界国际版下载 好看的玄幻小说 手机推荐排行榜 好看的小说完本推荐 完美的世界 1993 电影 穿越小说排行榜 小说网 玄幻小说排行榜 大主宰之灵路天蚕土豆 有声小说 完美世界有声小说全集 魔天记 忘语 小说 玄幻小说排行榜 辰东 天域苍穹 我吃西红柿 欢乐颂小说结局是什么 懒人听书 已完本玄幻小说排行榜 盗墓笔记小说 辰东 有声读物 玄幻小说排行榜完本 完美世界有声小说 雪鹰领主 完美世界小说下载 好看的小说完本推荐 完美世界辰东 完美世界辰东小说下载 有声小说 穿越小说完本 君子以泽 盗墓笔记有声小说 辰东 有声读物 最好看的小说排行 遮天 辰东 小说 欢乐颂小说txt 盗墓笔记小说下载 我欲封天 耳根 小说零 好看的课外书 小说排行榜完结版 殿上欢 欢乐颂小说结局是什么 完美世界有声小说 我欲封天 耳根 小说 我欲封天 耳根 小说零 穿越小说排行榜 琅琊榜 海宴 小说 《完美世界》txt全集 古风君子以泽 有声小说在线收听网 完美世界 辰东 小说 穿越小说排行榜 完美世界有声小说 听中国有声小说 已完本玄幻小说排行榜 辰东完美世界有声小说 欢乐颂第一季免费阅读 好看的小说 君子以泽 有声读物 我欲封天 耳根 小说零 欢乐颂第一季 我欲封天txt下载 盗墓笔记第二季 我欲封天txt下载 完美世界有声小说全集 完美世界辰东 兽性总裁的爱奴 盗墓笔记txt全集下载 遮天 小说改编的网页游戏 小说 欢乐颂第一季 旷世神医 有声 君子以泽 完美世界前传下载 天蚕土豆 欢乐颂第一季免费阅读 完美世界小说下载 我吃西红柿 欢乐颂第一季免费阅读 择天记 完美的世界 1993 电影 完美世界小说下载 风凌天下 雪鹰领主 盗墓笔记小说下载 武道至尊 帝临 小说 官场小说排行榜 遮天 网络小说排行榜 欢乐颂小说结局是什么 完美世界txt全集下载 懒人听书 神武八荒 一颗 小说 好看的言情小说 已完结小说排行榜 完结小说 梦入神机 遮天 辰东 小说笔趣阁 绝色狂妃 仙魅 小说 绝色狂妃 仙魅 小说 yy玄幻小说排行榜完本 官场小说排行榜 绝色狂妃 仙魅 小说 古风名字 好看的小说完本推荐 完美世界前传下载 大主宰之灵路天蚕土豆 遮天 辰东 小说 我欲封天 耳根 小说 好看的课外书 怎么写网络小说 千年殇 风凌天下 欢乐颂小说txt 盗墓笔记第二季 重生之毒妃 梅果 小说 天下 高月 小说 盗墓笔记小说全集 兽性总裁的爱奴 完美世界有声小说全集 我欲封天txt下载 小说改编的网页游戏 好看的历史书籍推荐 有声小说 欢乐颂第二季 小说网 完结小说排行榜 管理书籍排行榜 懒人听书 玄幻小说完本 好看的电视剧 好看的小说完本推荐 yy玄幻小说排行榜完本 大主宰 天蚕土豆 盗墓笔记小说 管理书籍排行榜 好看的历史书籍推荐 《完美世界》txt全集 梦入神机 盗墓笔记txt全集下载 琅琊榜 海宴 小说 玄幻小说改编的电视剧 完美世界 辰东 小说 长生界 辰东 小说 武道至尊 帝临 小说 盗墓笔记小说 女人书籍排行榜 有声读物 小说 完美的世界 1993 电影 我欲封天 遮天 盗墓笔记全集 天蚕土豆 小说网 我欲封天 耳根 小说 大主宰 天蚕土豆 小说阅读器 网络小说排行榜 完美世界辰东 玄幻小说 完美世界辰东 小说 玄幻小说 大主宰 盗墓笔记小说txt下载 完美世界小说下载 神武八荒 一颗 小说 辰东 欢乐颂小说txt 欢乐颂小说结局 盗墓笔记 大主宰txt全集下载 君子以泽 长生界 辰东 小说 好看的课外书 盗墓笔记有声小说 网络小说排行榜 我吃西红柿 我欲封天 耳根 小说零 完美世界前传下载 好看的小说 我欲封天txt下载 辰东完美世界有声小说 完结小说排行榜 欢乐颂小说在线阅读 完美世界前传下载 小说网 完结小说排行榜 我欲封天 耳根 小说 辰东 玄幻小说排行榜 完结小说 我欲封天 绝色狂妃 仙魅 小说 大主宰 天蚕土豆 小说 梦入神机 玄幻小说排行榜 怎么写网络小说 天下 高月 小说 懒人听书 有声小说下载 官场小说排行榜 古风君子以泽 盗墓笔记小说 我欲封天 耳根 小说 古风小说 君子以泽 我欲封天txt下载 完美世界官网 听中国有声小说 我欲封天txt下载 辰东完美世界有声小说 完美的世界 1993 电影 欢乐颂小说结局是什么 有声 魔天记 忘语 小说 盗墓笔记第二季 神武八荒 一颗 小说 好看的小说 盗墓笔记小说全集 我欲封天txt下载 遮天 辰东 小说 玄幻小说改编的电视剧 大主宰txt全集下载 欢乐颂第二季 盗墓笔记 盗墓笔记第二季 穿越小说完本 玄幻小说完本 玄幻小说排行榜 小说阅读网免费小说 辰东完美世界有声小说 玄幻小说排行榜完本 君子以泽 盛世嫡妃 凤轻 小说 完美世界辰东 好看的历史书籍推荐 风凌天下 遮天 辰东 小说 小说阅读网免费小说 有声小说打包下载 完美世界小说下载 官场小说排行榜 完美的世界 1993 电影 我吃西红柿 玄幻小说 欢乐颂小说 大主宰 天蚕土豆 小说 欢乐颂第一季 好看的小说完本推荐 欢乐颂第一季免费阅读 欢乐颂小说结局 我欲封天 耳根 小说 我欲封天 盗墓笔记txt全集下载 欢乐颂 绝色狂妃 仙魅 小说 穿越小说完本 玄幻小说排行榜完本 完美世界辰东小说下载 小说排行榜 有声小说下载 欢乐颂小说txt 梦入神机 小说阅读器 武道至尊 帝临 小说 新寡妇村传奇 盗墓笔记txt全集下载 斗破苍穹续集 好看的言情小说 梦入神机 最好看的小说排行 琅琊榜 海宴 小说 旷世神医 有声小说在线收听网 小说网 我欲封天txt下载 已完本玄幻小说排行榜 我欲封天 耳根 小说 言情小说 君子以泽 小说阅读器 好看的小说 君子以泽 盗墓笔记小说txt下载 遮天 手机推荐排行榜 完美世界 择天记 完结小说排行榜 将夜 猫腻 小说 玄幻小说排行榜 玄幻小说排行榜 管理书籍排行榜 神武八荒 一颗 小说 完美世界辰东小说下载 绝色狂妃 仙魅 小说 有声小说 管理书籍排行榜 网络小说排行榜 有声小说打包下载 小说排行榜 如何发布网络小说 好看的小说完本推荐 有声读物 有声小说打包下载 盗墓笔记小说全集 完美世界有声小说 将夜 猫腻 小说 欢乐颂小说结局是什么 武道至尊 帝临 小说 盗墓笔记小说 天域苍穹 完美的世界 1993 电影 兽性总裁的爱奴 兽性总裁的爱奴 古风名字 玄幻小说排行榜完本 已完结小说排行榜 辰东完美世界有声小说 大主宰 天蚕土豆 盗墓笔记第二季 完美世界辰东小说下载 大主宰之灵路天蚕土豆 天域苍穹 重生之毒妃 梅果 小说 好看的历史书籍推荐 欢乐颂小说结局是什么 遮天 辰东 小说笔趣阁 完结小说排行榜 玄幻小说改编的电视剧 小说排行榜 好看的小说完本推荐 完美世界辰东 盗墓笔记txt全集下载 盗墓笔记同人小说 手机推荐排行榜 玄幻小说排行榜 小说改编的网页游戏 女人书籍排行榜 旷世神医 神武八荒 一颗 小说 完美世界有声小说全集 盗墓笔记有声小说 殿上欢 小说 耳根 玄幻小说改编的电视剧 盗墓笔记有声小说 小说阅读网 管理书籍排行榜 我欲封天 完结小说排行榜 穿越小说完本 大主宰 天蚕土豆 小说 大主宰 完美世界辰东 好看的小说 君子以泽 完美世界 辰东 小说 兽性总裁的爱奴 完美世界辰东小说下载 欢乐颂小说结局 天蚕土豆 好看的小说 盗墓笔记全集 古风小说 小说排行榜完结版 大主宰之灵路天蚕土豆 欢乐颂第一季 yy玄幻小说排行榜完本 神武八荒 一颗 小说 欢乐颂小说txt 盗墓笔记小说下载 盗墓笔记小说txt下载 武道至尊 帝临 小说 天下 高月 小说 小说网 完结小说排行榜 穿越小说排行榜 已完本玄幻小说排行榜 琅琊榜 海宴 小说 听中国有声小说 完美世界 辰东 小说 有声读物 完美世界官网 女人书籍排行榜 欢乐颂第二季 小说阅读网 完美世界txt全集下载 唐家三少 好看的课外书 好看的历史书籍推荐 完美世界有声小说全集 我欲封天 耳根 小说 性爱有声小说在线收听 大主宰之灵路天蚕土豆 好看的电视剧 雪鹰领主 大主宰之灵路天蚕土豆 如何发布网络小说 完美的世界 1993 电影 性爱有声小说在线收听 魔天记 忘语 小说 完美世界有声小说 天蚕土豆 玄幻小说排行榜 盗墓笔记txt全集下载 重生之毒妃 梅果 小说 殿上欢 有声读物 女人书籍排行榜 好看的玄幻小说 欢乐颂小说txt 唐家三少 梦入神机 已完本玄幻小说排行榜 天域苍穹 听中国有声小说 辰东完美世界有声小说 盗墓笔记 将夜 猫腻 小说 新寡妇村传奇 古风名字 好看的玄幻小说 绝色狂妃 仙魅 小说 我欲封天 耳根 小说 盗墓笔记全集 已完结小说排行榜 小说阅读器 有声小说 完美世界txt全集下载 最好看的小说排行 灵域 盗墓笔记 完美世界小说txt下载 好看的玄幻小说 欢乐颂第三季 最好看的小说排行 君子以泽 小说排行榜完结版 盗墓笔记txt全集下载 我吃西红柿 大主宰 天蚕土豆 有声小说下载 小说 小说排行榜 女人书籍排行榜 千年殇 国际完美世界下载 欢乐颂小说结局是什么 武道至尊 帝临 小说 遮天 好看的玄幻小说 盗墓笔记同人小说 国际完美世界下载 小说阅读网免费小说 《完美世界》txt全集 完美世界辰东 小说阅读网 有声小说下载 有声 将夜 猫腻 小说 怎么写网络小说 有声小说在线收听网 辰东完美世界有声小说 辰东 最好看的小说排行 重生之毒妃 梅果 小说 完美世界 辰东 小说 唐家三少 怎样写网络小说 遮天 女强穿越玄幻完结小说 完美世界辰东 梦入神机 《完美世界》txt全集 完美世界有声小说全集 有声读物 yy玄幻小说排行榜完本 武道至尊 帝临 小说 古风 斗破苍穹续集 完结小说 玄幻小说排行榜完本 已完本玄幻小说排行榜 玄幻小说完本 如何发布网络小说 玄幻小说排行榜完本 欢乐颂小说结局是什么 国际完美世界下载 完美世界辰东 有声读物 完美世界辰东 梦入神机 辰东完美世界有声小说 我欲封天txt下载 有声读物 已完结小说排行榜 盗墓笔记同人小说 重生之毒妃 梅果 小说 最好看的小说排行 完美世界国际版下载 完美世界txt下载 盗墓笔记同人小说 好看的历史书籍推荐 梦入神机 小说阅读网 完美世界txt全集下载 旷世神医 古风名字 听中国有声小说 网络小说排行榜 豆豆小说阅读网 盗墓笔记小说txt下载 欢乐颂第一季 网络小说排行榜 好看的课外书 唐家三少 风凌天下 旷世神医 古风名字 完美世界小说txt下载 完美世界官网 如何发布网络小说 完美世界国际版下载 旷世神医 完美世界 辰东 小说 怎么写网络小说 遮天 女强穿越玄幻完结小说 大主宰 小说阅读网免费小说 怎样写网络小说 有声读物 盗墓笔记txt全集下载 完美世界前传下载 天域苍穹 小说排行榜 玄幻小说完本 完美世界txt下载 小说阅读网 盛世嫡妃 凤轻 小说 最好看的小说排行 小说阅读网站 遮天 我欲封天 耳根 小说 有声小说 已完本玄幻小说排行榜 欢乐颂第三季 欢乐颂小说 天蚕土豆 完美世界小说下载 我欲封天txt下载 有声读物 完美世界前传下载 懒人听书 古风小说 君子以泽 玄幻小说 古风名字 君子以泽 琅琊榜 海宴 小说 盗墓笔记小说下载 小说阅读网站 好看的小说完本推荐 穿越小说完本 网络小说排行榜 兽性总裁的爱奴 小说 好看的小说完本推荐 欢乐颂第二季 雪鹰领主 怎么写网络小说 欢乐颂 小说改编的网页游戏 完美世界有声小说全集 好看的课外书 盗墓笔记同人小说 好看的玄幻小说 玄幻小说完本 盗墓笔记全集 完美世界txt全集下载 完美的世界 1993 电影 风凌天下 欢乐颂小说在线阅读 yy玄幻小说排行榜完本 有声小说 古风小说 君子以泽 手机推荐排行榜 完美世界辰东 我欲封天txt下载 手机推荐排行榜 天域苍穹 神武八荒 一颗 小说 欢乐颂第二季 女人书籍排行榜 欢乐颂第二季 琅琊榜 海宴 小说 盗墓笔记txt全集下载 如何发布网络小说 懒人听书 有声读物 盛世嫡妃 凤轻 小说 怎样写网络小说 如何发布网络小说 好看的历史书籍推荐 盗墓笔记全集 最好看的小说排行 完美世界国际版下载 兽性总裁的爱奴 新寡妇村传奇 盗墓笔记全集 完结小说 网络小说排行榜 我欲封天txt下载 魔天记 忘语 小说 旷世神医 欢乐颂小说结局是什么 完美世界有声小说 完美世界 辰东 小说 盗墓笔记同人小说 小说阅读网站 新寡妇村传奇 欢乐颂第二季 完美的世界 1993 电影 小说阅读器 小说排行榜 穿越小说排行榜 大主宰 玄幻小说完本 盗墓笔记 好看的玄幻小说 我欲封天 耳根 小说 小说排行榜完结版 欢乐颂第二季 小说排行榜完结版 盗墓笔记小说txt下载 辰东完美世界有声小说 好看的小说完本推荐 小说阅读网 大主宰 天蚕土豆 小说 辰东 梦入神机 《完美世界》txt全集 古风名字 盗墓笔记小说txt下载 欢乐颂小说 遮天 神武八荒 一颗 小说 有声读物 兽性总裁的爱奴 玄幻小说完本 好看的玄幻小说 盗墓笔记全集 网络小说排行榜 听中国有声小说 好看的小说完本推荐 欢乐颂第二季 天下 高月 小说 懒人听书 女人书籍排行榜 懒人听书 重生之毒妃 梅果 小说 辰东 有声小说 盗墓笔记 千年殇 玄幻小说完本 好看的小说完本推荐 盗墓笔记小说 天下 高月 小说 武道至尊 帝临 小说 欢乐颂第二季 盗墓笔记同人小说 完结小说排行榜 欢乐颂第一季 盗墓笔记小说txt下载 如何发布网络小说 性爱有声小说在线收听 有声小说 有声 殿上欢 有声读物 好看的小说 君子以泽 绝色狂妃 仙魅 小说 我吃西红柿 完美世界前传下载 灵域 好看的小说完本推荐 完美世界有声小说全集 兽性总裁的爱奴 千年殇 梦入神机 完美世界国际版下载 千年殇 玄幻小说 耳根 盗墓笔记txt全集下载 欢乐颂小说结局 天蚕土豆 君子以泽 古风名字 神武八荒 一颗 小说 欢乐颂 盗墓笔记有声小说 国际完美世界下载 神武八荒 一颗 小说 绝色狂妃 仙魅 小说 女人书籍排行榜 大主宰 天蚕土豆 有声小说在线收听网 小说 性爱有声小说在线收听 完美世界官网 我欲封天 完美世界有声小说 懒人听书 完美世界国际版下载 君子以泽 好看的历史书籍推荐 已完本玄幻小说排行榜 盗墓笔记小说下载 辰东 懒人听书 完美世界官网 我欲封天 最好看的小说排行 择天记 我吃西红柿 网络小说排行榜 玄幻小说 欢乐颂第三季 天蚕土豆 玄幻小说排行榜完本 大主宰 大主宰 天蚕土豆 小说 辰东 网络小说排行榜 我欲封天 盗墓笔记小说txt下载 遮天 辰东 小说笔趣阁 盗墓笔记第二季 遮天 辰东 小说 欢乐颂第二季 女人书籍排行榜 怎样写网络小说 完美世界前传下载 欢乐颂小说 古风小说 君子以泽 盗墓笔记全集 国际完美世界下载 古风小说 如何发布网络小说 盗墓笔记小说全集 手机推荐排行榜 好看的小说 君子以泽 完美世界前传下载 盗墓笔记有声小说 完美世界国际版下载 盗墓笔记有声小说 欢乐颂小说结局 完美世界有声小说全集 豆豆小说阅读网 女人书籍排行榜 小说阅读网免费小说 怎么写网络小说 完美世界有声小说全集 雪鹰领主 辰东 小说阅读网站 唐家三少 完美世界辰东 雪鹰领主 好看的言情小说 有声小说 大主宰txt全集下载 我欲封天 完结小说 完美世界辰东 穿越小说完本 已完结小说排行榜 如何发布网络小说 小说阅读器 雪鹰领主 我吃西红柿 网络小说排行榜 琅琊榜 海宴 小说 殿上欢 《完美世界》txt全集 古风名字 欢乐颂第一季 辰东全部小说 遮天 辰东 小说 怎样写网络小说 风凌天下 梦入神机 古风小说 完美世界小说txt下载 盗墓笔记小说txt下载 《完美世界》txt全集 完美世界小说txt下载 完美世界有声小说全集 完美世界txt下载 辰东 如何发布网络小说 武道至尊 帝临 小说 女强穿越玄幻完结小说 大主宰之灵路天蚕土豆 择天记 听中国有声小说 完美世界有声小说全集 盗墓笔记 懒人听书 女人书籍排行榜 好看的历史书籍推荐 有声小说下载 梦入神机 欢乐颂小说txt 官场小说排行榜 灵域 风凌天下 辰东 大主宰 天蚕土豆 小说 怎么写网络小说 梦入神机 风凌天下 怎样写网络小说 玄幻小说改编的电视剧 有声 大主宰 天蚕土豆 小说 琅琊榜 海宴 小说 神武八荒 一颗 小说 天域苍穹 完美世界前传下载 言情小说 君子以泽 欢乐颂第一季 完结小说排行榜 小说排行榜 穿越小说排行榜 完美世界前传下载 玄幻小说排行榜 玄幻小说改编的电视剧 辰东完美世界有声小说 完美世界 辰东 小说 盗墓笔记小说 我欲封天 耳根 小说零 小说阅读网 完美世界前传下载 我吃西红柿 完美世界前传下载 欢乐颂小说在线阅读 盛世嫡妃 凤轻 小说 穿越小说完本 风凌天下 欢乐颂小说在线阅读 完美世界辰东小说下载 有声小说打包下载 完美世界国际版下载 完美世界小说下载 我吃西红柿 怎么写网络小说 豆豆小说阅读网 千年殇 小说排行榜 完美世界国际版下载 有声 古风名字 盗墓笔记txt全集下载 有声小说 已完本玄幻小说排行榜 完美世界官网 已完结小说排行榜 盗墓笔记小说txt下载 小说排行榜完结版 欢乐颂小说结局是什么 神武八荒 一颗 小说 完美世界有声小说 小说排行榜 言情小说 君子以泽 好看的课外书 欢乐颂第二季 千年殇 管理书籍排行榜 完美世界小说下载 玄幻小说排行榜完本 我欲封天txt下载 玄幻小说改编的电视剧 如何发布网络小说 网络小说排行榜 官场小说排行榜 完美世界前传下载 有声小说下载 小说阅读网免费小说 雪鹰领主 手机推荐排行榜 怎样写网络小说 雪鹰领主 完美世界有声小说全集 完美世界 辰东 小说 绝色狂妃 仙魅 小说 遮天 辰东 小说 有声小说在线收听网 好看的课外书 遮天 好看的历史书籍推荐 盗墓笔记小说txt下载 我欲封天 耳根 小说 穿越小说排行榜 古风名字 完结小说 辰东全部小说 穿越小说排行榜 盗墓笔记全集 性爱有声小说在线收听 大主宰txt全集下载 古风小说 小说改编的网页游戏 欢乐颂小说在线阅读 玄幻小说完本 玄幻小说排行榜完本 欢乐颂第三季 官场小说排行榜 有声读物 已完本玄幻小说排行榜 女强穿越玄幻完结小说 完美世界txt下载 完结小说排行榜 欢乐颂小说在线阅读 盗墓笔记 盗墓笔记有声小说 盗墓笔记小说下载 我欲封天txt下载 官场小说排行榜 yy玄幻小说排行榜完本 古风 雪鹰领主 完结小说排行榜 好看的小说 好看的小说 盗墓笔记小说 欢乐颂小说结局是什么 武道至尊 帝临 小说 天蚕土豆 小说阅读网免费小说 我欲封天 耳根 小说 遮天 完结小说排行榜 盗墓笔记有声小说 穿越小说排行榜 穿越小说完本 盗墓笔记有声小说 欢乐颂 网络小说排行榜 重生之毒妃 梅果 小说 大主宰 天蚕土豆 择天记 盗墓笔记同人小说 大主宰 天蚕土豆 最好看的小说排行 魔天记 忘语 小说 玄幻小说排行榜完本 魔天记 忘语 小说 欢乐颂小说 好看的小说 《完美世界》txt全集 我欲封天 雪鹰领主 有声 神武八荒 一颗 小说 盗墓笔记小说全集 玄幻小说改编的电视剧 小说排行榜完结版 官场小说排行榜 唐家三少 唐家三少 完美世界 辰东 小说 我吃西红柿 豆豆小说阅读网 盗墓笔记第二季 欢乐颂第二季 大主宰 天蚕土豆 天下 高月 小说 遮天 好看的电视剧 古风名字 魔天记 忘语 小说 武道至尊 帝临 小说 雪鹰领主 完美世界官网 豆豆小说阅读网 雪鹰领主 古风 君子以泽 管理书籍排行榜 穿越小说完本 女强穿越玄幻完结小说 大主宰 天蚕土豆 小说 大主宰 天蚕土豆 小说 完美世界txt全集下载 完美世界 辰东 小说 耳根 天域苍穹 兽性总裁的爱奴 女人书籍排行榜 完美世界txt全集下载 盗墓笔记全集 玄幻小说完本 玄幻小说完本 完美世界国际版下载 梦入神机 盛世嫡妃 凤轻 小说 新寡妇村传奇 最好看的小说排行 辰东全部小说 玄幻小说排行榜完本 玄幻小说完本 斗破苍穹续集 新寡妇村传奇 女人书籍排行榜 有声 我欲封天txt下载 欢乐颂第一季免费阅读 好看的言情小说 大主宰 雪鹰领主 完美世界国际版下载 我欲封天txt下载 欢乐颂第一季免费阅读 风凌天下 欢乐颂第一季免费阅读 完美世界txt全集下载 绝色狂妃 仙魅 小说 小说排行榜 国际完美世界下载 完结小说排行榜 风凌天下 已完结小说排行榜 网络小说排行榜 欢乐颂第一季免费阅读 完美世界辰东小说下载 大主宰之灵路天蚕土豆 小说排行榜 大主宰 完美世界txt全集下载 官场小说排行榜 已完结小说排行榜 我欲封天 耳根 小说零 手机推荐排行榜 我欲封天 耳根 小说 盗墓笔记 完美世界 辰东 小说 懒人听书 好看的小说 武道至尊 帝临 小说 雪鹰领主 懒人听书 古风小说 君子以泽 琅琊榜 海宴 小说 殿上欢 听中国有声小说 完美世界国际版下载 完美世界辰东小说下载 将夜 猫腻 小说 管理书籍排行榜 我欲封天txt下载 古风名字 有声小说下载 兽性总裁的爱奴 灵域 盗墓笔记小说全集 盗墓笔记 琅琊榜 海宴 小说 盗墓笔记第二季 武道至尊 帝临 小说 好看的历史书籍推荐 盗墓笔记小说 如何发布网络小说 欢乐颂第一季免费阅读 官场小说排行榜 大主宰txt全集下载 大主宰 天蚕土豆 已完结小说排行榜 盗墓笔记小说下载 有声小说 管理书籍排行榜 盗墓笔记全集 盛世嫡妃 凤轻 小说 如何发布网络小说 小说阅读网免费小说 魔天记 忘语 小说 最好看的小说排行 欢乐颂 完结小说 梦入神机 欢乐颂小说结局 盗墓笔记小说 完美世界小说txt下载 欢乐颂小说结局是什么 完美世界辰东小说下载 好看的言情小说 耳根 将夜 猫腻 小说 完美世界有声小说 古风小说 女人书籍排行榜 小说阅读网站 小说排行榜完结版 神武八荒 一颗 小说 殿上欢 梦入神机 管理书籍排行榜 欢乐颂小说结局是什么 好看的玄幻小说 欢乐颂 大主宰txt全集下载 雪鹰领主 玄幻小说改编的电视剧 欢乐颂第二季 殿上欢 《完美世界》txt全集 小说阅读网免费小说 欢乐颂第三季 国际完美世界下载 怎样写网络小说 我欲封天txt下载 欢乐颂第二季 言情小说 君子以泽 性爱有声小说在线收听 怎么写网络小说 盗墓笔记小说下载 完美世界有声小说全集 盗墓笔记全集 穿越小说完本 琅琊榜 海宴 小说 玄幻小说改编的电视剧 玄幻小说排行榜完本 网络小说排行榜 豆豆小说阅读网 完美世界小说txt下载 辰东完美世界有声小说 欢乐颂第一季免费阅读 玄幻小说排行榜完本 我欲封天 耳根 小说 古风 完美世界小说下载 完美世界 辰东 小说 有声读物 穿越小说排行榜 小说 欢乐颂第三季 小说排行榜 欢乐颂小说结局 欢乐颂第三季 好看的言情小说 有声小说 我欲封天txt下载 遮天 完美世界txt全集下载 殿上欢 欢乐颂小说txt 盗墓笔记小说全集 完美世界官网 重生之毒妃 梅果 小说 盗墓笔记有声小说 遮天 将夜 猫腻 小说 梦入神机 辰东完美世界有声小说 千年殇 好看的小说 好看的玄幻小说 盗墓笔记小说txt下载 欢乐颂第一季 女人书籍排行榜 盗墓笔记小说 斗破苍穹续集 小说排行榜 盗墓笔记全集 我欲封天 耳根 小说零 我欲封天txt下载 我欲封天 耳根 小说 完美世界小说下载 我吃西红柿 大主宰 大主宰之灵路天蚕土豆 将夜 猫腻 小说 完美的世界 1993 电影 性爱有声小说在线收听 雪鹰领主 欢乐颂第二季 完美的世界 1993 电影 如何发布网络小说 欢乐颂 穿越小说完本 女人书籍排行榜 国际完美世界下载 我欲封天txt下载 好看的玄幻小说 君子以泽 玄幻小说排行榜 古风名字 小说排行榜 盗墓笔记txt全集下载 灵域 大主宰之灵路天蚕土豆 我欲封天 耳根 小说零 重生之毒妃 梅果 小说 欢乐颂 盗墓笔记小说 盗墓笔记 怎样写网络小说 小说网 完美世界辰东 遮天 完美世界 辰东 小说 魔天记 忘语 小说 有声小说下载 唐家三少 管理书籍排行榜 完美世界前传下载 穿越小说排行榜 欢乐颂第一季免费阅读 好看的历史书籍推荐 古风 神武八荒 一颗 小说 已完结小说排行榜 小说阅读器 如何发布网络小说 耳根 新寡妇村传奇 玄幻小说排行榜 穿越小说排行榜 欢乐颂第三季 yy玄幻小说排行榜完本 好看的言情小说 雪鹰领主 古风名字 好看的小说 性爱有声小说在线收听 大主宰 绝色狂妃 仙魅 小说 唐家三少 盗墓笔记 盗墓笔记第二季 有声 完美世界 辰东 小说 完结小说 完美世界前传下载 雪鹰领主 我欲封天txt下载 小说阅读网免费小说 玄幻小说改编的电视剧 小说 完美世界 完结小说排行榜 我欲封天txt下载 小说阅读网免费小说 完美世界小说下载 完美世界小说下载 小说改编的网页游戏 完美世界辰东 绝色狂妃 仙魅 小说 《完美世界》txt全集 好看的历史书籍推荐 《完美世界》txt全集 辰东全部小说 完美世界txt下载 重生之毒妃 梅果 小说 网络小说排行榜 古风名字 殿上欢 小说改编的网页游戏 好看的电视剧 好看的历史书籍推荐 遮天 辰东 小说笔趣阁 完美的世界 1993 电影 有声小说下载 盗墓笔记有声小说 已完结小说排行榜 完美世界前传下载 大主宰之灵路天蚕土豆 管理书籍排行榜 好看的言情小说 盗墓笔记小说 有声小说 yy玄幻小说排行榜完本 《完美世界》txt全集 旷世神医 大主宰 魔天记 忘语 小说 小说阅读网站 手机推荐排行榜 好看的历史书籍推荐 欢乐颂第一季 新寡妇村传奇 好看的课外书 好看的玄幻小说 辰东全部小说 完美世界辰东 欢乐颂第二季 完美世界小说下载 穿越小说完本 盗墓笔记同人小说 我欲封天 耳根 小说零 官场小说排行榜 武道至尊 帝临 小说 穿越小说排行榜 我欲封天 耳根 小说零 欢乐颂小说结局是什么 怎样写网络小说 欢乐颂小说在线阅读 古风名字 大主宰 天蚕土豆 小说 盗墓笔记txt全集下载 大主宰 天蚕土豆 小说 君子以泽 梦入神机 完美世界 辰东 小说 完美世界 大主宰txt全集下载 完结小说排行榜 辰东全部小说 古风 旷世神医 手机推荐排行榜 盛世嫡妃 凤轻 小说 小说排行榜 管理书籍排行榜 欢乐颂小说在线阅读 管理书籍排行榜 小说阅读网站 豆豆小说阅读网 小说阅读器 欢乐颂第一季 完美世界txt下载 盗墓笔记第二季 小说网 有声小说 小说阅读网站 好看的课外书 盗墓笔记有声小说 欢乐颂第一季免费阅读 盗墓笔记小说 古风 唐家三少 小说 欢乐颂第三季 斗破苍穹续集 完美世界小说下载 完美世界前传下载 已完本玄幻小说排行榜 武道至尊 帝临 小说 我吃西红柿 完美世界有声小说全集 我欲封天txt下载 天下 高月 小说 遮天 辰东 小说 有声小说 欢乐颂小说结局是什么 大主宰之灵路天蚕土豆 小说阅读网 玄幻小说完本 君子以泽 欢乐颂第二季 已完结小说排行榜 天蚕土豆 性爱有声小说在线收听 好看的言情小说 盗墓笔记第二季 择天记 欢乐颂小说结局是什么 大主宰之灵路天蚕土豆 小说 大主宰 我欲封天txt下载 琅琊榜 海宴 小说 完美世界小说下载 穿越小说完本 有声读物 小说网 穿越小说排行榜 完结小说排行榜 有声小说下载 完美世界txt全集下载 我吃西红柿 我吃西红柿 欢乐颂第三季 唐家三少 盗墓笔记全集 管理书籍排行榜 穿越小说排行榜 有声小说下载 欢乐颂小说结局是什么 小说阅读网免费小说 完美世界有声小说 网络小说排行榜 魔天记 忘语 小说 完美世界辰东 辰东 我欲封天 耳根 小说零 言情小说 君子以泽 女强穿越玄幻完结小说 懒人听书 完美世界txt全集下载 我欲封天txt下载 天蚕土豆 雪鹰领主 完美世界辰东小说下载 新寡妇村传奇 欢乐颂小说结局是什么 遮天 管理书籍排行榜 小说排行榜 有声小说在线收听网 有声小说打包下载 懒人听书 管理书籍排行榜 好看的历史书籍推荐 小说排行榜完结版 有声小说打包下载 盗墓笔记第二季 完结小说 我欲封天 天下 高月 小说 有声读物 辰东完美世界有声小说 兽性总裁的爱奴 盗墓笔记全集 小说网 兽性总裁的爱奴 小说阅读网站 手机推荐排行榜 神武八荒 一颗 小说 完美世界有声小说 管理书籍排行榜 完美世界有声小说全集 小说阅读器 完美的世界 1993 电影 怎样写网络小说 完美世界辰东小说下载 已完本玄幻小说排行榜 穿越小说排行榜 有声小说 完美世界txt下载 盗墓笔记 斗破苍穹续集 重生之毒妃 梅果 小说 魔天记 忘语 小说 辰东 小说阅读网 武道至尊 帝临 小说 国际完美世界下载 小说阅读器 小说阅读网免费小说 最好看的小说排行 魔天记 忘语 小说 豆豆小说阅读网 君子以泽 小说阅读网站 我吃西红柿 完美世界前传下载 最好看的小说排行 《完美世界》txt全集 小说阅读网站 好看的言情小说 唐家三少 天蚕土豆 国际完美世界下载 完美世界 辰东 小说 穿越小说排行榜 魔天记 忘语 小说 完美世界小说下载 盗墓笔记同人小说 有声读物 盗墓笔记 古风名字 欢乐颂 完美世界小说下载 完美世界txt全集下载 盗墓笔记第二季 灵域 怎么写网络小说 欢乐颂第一季 风凌天下 有声读物 我吃西红柿 斗破苍穹续集 好看的言情小说 天下 高月 小说 盗墓笔记同人小说 魔天记 忘语 小说 天蚕土豆 完结小说 小说排行榜 盗墓笔记 天蚕土豆 盗墓笔记有声小说 完美世界辰东 盗墓笔记txt全集下载 神武八荒 一颗 小说 我欲封天 耳根 小说 小说排行榜 灵域 神武八荒 一颗 小说 辰东 魔天记 忘语 小说 完结小说 完结小说排行榜 遮天 辰东 小说笔趣阁 完美世界国际版下载 我吃西红柿 有声 性爱有声小说在线收听 盗墓笔记第二季 君子以泽 琅琊榜 海宴 小说 完结小说排行榜 网络小说排行榜 辰东 完美世界txt全集下载 欢乐颂第一季 有声 择天记 大主宰之灵路天蚕土豆 我吃西红柿 斗破苍穹续集 盛世嫡妃 凤轻 小说 完美世界有声小说全集 最好看的小说排行 完美世界辰东 好看的玄幻小说 古风君子以泽 遮天 女人书籍排行榜 辰东完美世界有声小说 完美世界辰东 玄幻小说排行榜 欢乐颂小说结局是什么 绝色狂妃 仙魅 小说 已完本玄幻小说排行榜 女强穿越玄幻完结小说 大主宰 天蚕土豆 古风小说 完美世界辰东 女强穿越玄幻完结小说 玄幻小说 古风名字 好看的小说完本推荐 辰东全部小说 有声小说下载 玄幻小说排行榜完本 辰东全部小说 盗墓笔记 兽性总裁的爱奴 完美世界辰东 殿上欢 玄幻小说改编的电视剧 盗墓笔记小说 欢乐颂第二季 魔天记 忘语 小说 完结小说排行榜 小说排行榜完结版 欢乐颂小说结局 玄幻小说排行榜完本 遮天 武道至尊 帝临 小说 小说阅读网免费小说 盗墓笔记有声小说 完美世界辰东 雪鹰领主 我吃西红柿 性爱有声小说在线收听 完美世界txt全集下载 盗墓笔记小说 有声读物 小说阅读网 有声小说 我欲封天txt下载 已完本玄幻小说排行榜 小说排行榜完结版 古风名字 雪鹰领主 天蚕土豆 欢乐颂第三季 完结小说排行榜 雪鹰领主 天下 高月 小说 我欲封天 古风小说 君子以泽 完美世界有声小说 怎么写网络小说 已完本玄幻小说排行榜 绝色狂妃 仙魅 小说 完美世界小说txt下载 好看的小说完本推荐 好看的小说 君子以泽 盗墓笔记第二季 武道至尊 帝临 小说 欢乐颂第二季 已完结小说排行榜 欢乐颂第一季 完美世界 辰东 小说 完结小说排行榜 殿上欢 古风小说 君子以泽 盗墓笔记全集 小说改编的网页游戏 欢乐颂第二季 有声小说打包下载 网络小说排行榜 管理书籍排行榜 古风名字 完结小说排行榜 国际完美世界下载 好看的课外书 盗墓笔记全集 豆豆小说阅读网 最好看的小说排行 千年殇 盛世嫡妃 凤轻 小说 完美的世界 1993 电影 管理书籍排行榜 完美世界国际版下载 已完本玄幻小说排行榜 完美世界小说下载 小说阅读网免费小说 听中国有声小说 怎样写网络小说 有声读物 好看的玄幻小说 最好看的小说排行 大主宰txt全集下载 欢乐颂第二季 《完美世界》txt全集 重生之毒妃 梅果 小说 完美世界国际版下载 玄幻小说改编的电视剧 盗墓笔记小说txt下载 盗墓笔记小说txt下载 将夜 猫腻 小说 将夜 猫腻 小说 武道至尊 帝临 小说 大主宰txt全集下载 有声小说 欢乐颂第一季免费阅读 已完结小说排行榜 完美世界 辰东 小说 盗墓笔记有声小说 我欲封天 完美的世界 1993 电影 古风小说 君子以泽 穿越小说排行榜 旷世神医 盗墓笔记全集 唐家三少 好看的小说完本推荐 小说排行榜 好看的小说 君子以泽 雪鹰领主 性爱有声小说在线收听 手机推荐排行榜 耳根 神武八荒 一颗 小说 盗墓笔记小说txt下载 盗墓笔记小说txt下载 遮天 辰东 小说 完美世界前传下载 完美世界小说下载 天蚕土豆 盗墓笔记第二季 斗破苍穹续集 完美的世界 1993 电影 新寡妇村传奇 好看的言情小说 欢乐颂小说 完结小说 耳根 武道至尊 帝临 小说 梦入神机 完美世界辰东小说下载 魔天记 忘语 小说 辰东 我吃西红柿 有声小说 遮天 辰东 小说笔趣阁 完美世界辰东 完美世界有声小说 绝色狂妃 仙魅 小说 盗墓笔记全集 魔天记 忘语 小说 遮天 好看的言情小说 完美的世界 1993 电影 怎样写网络小说 完美的世界 1993 电影 欢乐颂小说 最好看的小说排行 欢乐颂小说结局是什么 耳根 玄幻小说排行榜完本 我吃西红柿 玄幻小说排行榜完本 魔天记 忘语 小说 天域苍穹 管理书籍排行榜 小说改编的网页游戏 小说阅读器 有声小说打包下载 有声小说 辰东 我欲封天 耳根 小说 玄幻小说排行榜完本 欢乐颂第二季 欢乐颂小说txt 有声读物 《完美世界》txt全集 盗墓笔记有声小说 琅琊榜 海宴 小说 长生界 辰东 小说 女强穿越玄幻完结小说 小说阅读网 君子以泽 《完美世界》txt全集 我欲封天 古风小说 大主宰 天蚕土豆 梦入神机 辰东 怎么写网络小说 盗墓笔记同人小说 完美世界txt全集下载 天蚕土豆 《完美世界》txt全集 殿上欢 唐家三少 yy玄幻小说排行榜完本 穿越小说排行榜 完美世界前传下载 最好看的小说排行 欢乐颂 欢乐颂小说 欢乐颂小说结局是什么 懒人听书 梦入神机 完结小说排行榜 武道至尊 帝临 小说 有声小说下载 梦入神机 欢乐颂 盗墓笔记同人小说 好看的电视剧 豆豆小说阅读网 琅琊榜 海宴 小说 完美世界小说txt下载 女强穿越玄幻完结小说 天域苍穹 完美世界辰东小说下载 完美世界txt下载 好看的玄幻小说 穿越小说完本 魔天记 忘语 小说 性爱有声小说在线收听 穿越小说完本 盗墓笔记 大主宰 听中国有声小说 小说排行榜完结版 完美世界有声小说全集 盗墓笔记txt全集下载 小说网 小说排行榜 完美世界辰东 有声小说 完美世界有声小说 欢乐颂小说结局是什么 好看的言情小说 遮天 辰东 小说 遮天 辰东 小说 小说网 小说阅读网 完美世界前传下载 完美世界前传下载 古风名字 网络小说排行榜 殿上欢 小说阅读网站 完美世界txt全集下载 好看的玄幻小说 手机推荐排行榜 盛世嫡妃 凤轻 小说 我欲封天txt下载 有声小说下载 欢乐颂 好看的玄幻小说 盗墓笔记同人小说 小说阅读器 风凌天下 小说排行榜完结版 穿越小说排行榜 古风 玄幻小说改编的电视剧 怎样写网络小说 斗破苍穹续集 唐家三少 穿越小说完本 完美的世界 1993 电影 《完美世界》txt全集 盗墓笔记 盗墓笔记 好看的小说 完美世界 辰东 小说 我吃西红柿 斗破苍穹续集 完美世界小说txt下载 如何发布网络小说 古风小说 君子以泽 完美世界txt全集下载 完美世界辰东 我吃西红柿 怎样写网络小说 完结小说 小说阅读网免费小说 小说 遮天 天蚕土豆 好看的历史书籍推荐 雪鹰领主 完美世界国际版下载 欢乐颂第三季 最好看的小说排行 欢乐颂小说结局是什么 已完本玄幻小说排行榜 天下 高月 小说 有声小说 女强穿越玄幻完结小说 完美世界官网 我欲封天txt下载 完美世界有声小说全集 小说 yy玄幻小说排行榜完本 风凌天下 完美世界txt下载 完美世界前传下载 大主宰 天蚕土豆 小说 耳根 天蚕土豆 唐家三少 琅琊榜 海宴 小说 国际完美世界下载 手机推荐排行榜 欢乐颂小说txt 梦入神机 我欲封天 耳根 小说 懒人听书 好看的小说 君子以泽 玄幻小说改编的电视剧 斗破苍穹续集 有声小说打包下载 盗墓笔记第二季 官场小说排行榜 天下 高月 小说 欢乐颂第一季免费阅读 欢乐颂第三季 绝色狂妃 仙魅 小说 完美世界 辰东 小说 殿上欢 完美世界小说txt下载 遮天 辰东 小说 君子以泽 已完结小说排行榜 如何发布网络小说 好看的言情小说 穿越小说排行榜 有声小说下载 雪鹰领主 殿上欢 有声小说下载 完美世界有声小说 欢乐颂第一季免费阅读 欢乐颂小说在线阅读 盗墓笔记小说 懒人听书 《完美世界》txt全集 古风君子以泽 完美世界国际版下载 小说阅读网免费小说 有声小说下载 耳根 欢乐颂第一季 玄幻小说改编的电视剧 君子以泽 欢乐颂小说在线阅读 好看的小说完本推荐 《完美世界》txt全集 欢乐颂第一季免费阅读 小说排行榜完结版 绝色狂妃 仙魅 小说 已完结小说排行榜 完美世界小说txt下载 听中国有声小说 千年殇 小说网 怎么写网络小说 大主宰 天蚕土豆 小说 好看的课外书 盗墓笔记小说下载 重生之毒妃 梅果 小说 完美世界辰东小说下载 手机推荐排行榜 完美世界txt全集下载 懒人听书 已完本玄幻小说排行榜 遮天 盗墓笔记小说txt下载 豆豆小说阅读网 旷世神医 盗墓笔记 完美世界官网 完美的世界 1993 电影 女强穿越玄幻完结小说 我欲封天 遮天 盗墓笔记txt全集下载 辰东 玄幻小说 怎样写网络小说 我吃西红柿 完美世界前传下载 完美世界国际版下载 大主宰之灵路天蚕土豆 完美世界小说txt下载 手机推荐排行榜 欢乐颂第一季 欢乐颂小说结局是什么 盗墓笔记有声小说 《完美世界》txt全集 欢乐颂小说txt 怎么写网络小说 已完结小说排行榜 雪鹰领主 神武八荒 一颗 小说 我欲封天txt下载 有声小说下载 懒人听书 小说网 好看的小说 小说阅读网免费小说 小说网 欢乐颂 懒人听书 小说阅读网 耳根 《完美世界》txt全集 网络小说排行榜 欢乐颂 灵域 女强穿越玄幻完结小说 大主宰 天蚕土豆 好看的小说完本推荐 小说阅读网 小说网 网络小说排行榜 旷世神医 大主宰 欢乐颂小说txt 盗墓笔记小说txt下载 择天记 完美世界有声小说全集 盗墓笔记小说 完美世界官网 yy玄幻小说排行榜完本 管理书籍排行榜 手机推荐排行榜 古风小说 君子以泽 豆豆小说阅读网 殿上欢 怎么写网络小说 女强穿越玄幻完结小说 辰东全部小说 新寡妇村传奇 完美世界有声小说全集 盗墓笔记全集 好看的历史书籍推荐 我欲封天txt下载 好看的历史书籍推荐 大主宰之灵路天蚕土豆 长生界 辰东 小说 琅琊榜 海宴 小说 遮天 盗墓笔记第二季 懒人听书 穿越小说排行榜 耳根 小说排行榜完结版 大主宰之灵路天蚕土豆 盗墓笔记小说txt下载 性爱有声小说在线收听 yy玄幻小说排行榜完本 完美世界 辰东 小说 大主宰txt全集下载 懒人听书 有声读物 我欲封天 耳根 小说零 我欲封天 遮天 辰东 小说 辰东 我欲封天 耳根 小说零 我欲封天 耳根 小说 魔天记 忘语 小说 灵域 盗墓笔记小说 有声小说下载 手机推荐排行榜 有声小说在线收听网 小说阅读网 遮天 完美世界 辰东 小说 怎样写网络小说 天下 高月 小说 旷世神医 大主宰 女强穿越玄幻完结小说 小说网 言情小说 君子以泽 国际完美世界下载 大主宰 天蚕土豆 小说 言情小说 君子以泽 辰东全部小说 完美世界辰东小说下载 管理书籍排行榜 兽性总裁的爱奴 完美世界txt全集下载 小说排行榜完结版 遮天 完结小说 小说阅读器 风凌天下 盗墓笔记小说 玄幻小说排行榜 好看的小说 盛世嫡妃 凤轻 小说 欢乐颂第一季 小说网 完美世界辰东小说下载 君子以泽 殿上欢 已完本玄幻小说排行榜 言情小说 君子以泽 豆豆小说阅读网 欢乐颂小说在线阅读 遮天 辰东 小说笔趣阁 大主宰txt全集下载 玄幻小说排行榜完本 遮天 完美世界txt全集下载 好看的课外书 殿上欢 有声读物 灵域 懒人听书 将夜 猫腻 小说 盗墓笔记同人小说 完结小说 小说排行榜 网络小说排行榜 有声小说 玄幻小说排行榜完本 小说 魔天记 忘语 小说 好看的小说 君子以泽 绝色狂妃 仙魅 小说 斗破苍穹续集 君子以泽 小说阅读器 耳根 盗墓笔记 好看的玄幻小说 神武八荒 一颗 小说 千年殇 官场小说排行榜 大主宰 天蚕土豆 小说 盗墓笔记小说下载 完美世界 辰东 小说 好看的小说完本推荐 灵域 完美世界国际版下载 玄幻小说排行榜完本 遮天 小说阅读网 盗墓笔记同人小说 梦入神机 女人书籍排行榜 已完结小说排行榜 手机推荐排行榜 好看的言情小说 完美世界前传下载 武道至尊 帝临 小说 听中国有声小说 欢乐颂小说 小说 已完本玄幻小说排行榜 盗墓笔记全集 yy玄幻小说排行榜完本 有声读物 完结小说 已完本玄幻小说排行榜 yy玄幻小说排行榜完本 完美的世界 1993 电影 重生之毒妃 梅果 小说 小说网 欢乐颂小说txt 我欲封天txt下载 最好看的小说排行 武道至尊 帝临 小说 武道至尊 帝临 小说 盗墓笔记 欢乐颂小说 梦入神机 小说排行榜 盗墓笔记第二季 欢乐颂第三季 欢乐颂小说 盗墓笔记全集 辰东 懒人听书